INT101990

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Context Info
Confidence 0.33
First Reported 2002
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.69
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 2 99.76 Very High Very High Very High
Morphine 8 99.18 Very High Very High Very High
Inflammation 5 91.96 High High
cINOD 17 85.84 High High
opiate 2 82.96 Quite High
Dysuria 1 82.00 Quite High
opioid receptor 1 68.56 Quite High
cytokine 2 25.00 Low Low
antagonist 7 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 16 99.56 Very High Very High Very High
Carcinoma 3 99.48 Very High Very High Very High
Metaplasia 1 98.44 Very High Very High Very High
INFLAMMATION 6 91.96 High High
Colorectal Cancer 18 91.60 High High
Apoptosis 35 90.92 High High
Cancer 160 89.80 High High
Cyst 5 89.16 High High
Death 4 88.24 High High
Hemospermia 1 81.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sporadic p53 protein accumulation without evident gene mutations was also apparent in both the carcinoma and squamous metaplastic lesions.
Negative_regulation (apparent) of Positive_regulation (accumulation) of p53 protein associated with carcinoma
1) Confidence 0.33 Published 2002 Journal Pathol. Int. Section Abstract Doc Link 11972870 Disease Relevance 1.19 Pain Relevance 0.21
Pretreatment of the cells with 10nM morphine caused a transient, naloxone-reversible suppression of the appearance of activated p53 and the generation of DNA laddering.
Negative_regulation (suppression) of Positive_regulation (activated) of p53 associated with narcan and morphine
2) Confidence 0.33 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12927789 Disease Relevance 0.85 Pain Relevance 0.89
In HCT-116 cells, DADS induced p53 and NAG-1 in a dose-dependent manner and the induction of p53 preceded that of NAG-1.
Negative_regulation (preceded) of Positive_regulation (induction) of p53
3) Confidence 0.31 Published 2002 Journal J. Nutr. Section Abstract Doc Link 11925476 Disease Relevance 0.58 Pain Relevance 0.32
Moreover, it has been shown that p53 induction by HDAC inhibitors may completely deplete mutant p53, and such a sudden restoration is highly cytotoxic to cells harboring mutant p53 [59].
Spec (may) Negative_regulation (deplete) of Positive_regulation (induction) of p53
4) Confidence 0.30 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762324 Disease Relevance 0.27 Pain Relevance 0
Moreover, it has been shown that p53 induction by HDAC inhibitors may completely deplete mutant p53, and such a sudden restoration is highly cytotoxic to cells harboring mutant p53 [59].
Negative_regulation (inhibitors) of Positive_regulation (induction) of p53
5) Confidence 0.30 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762324 Disease Relevance 0.27 Pain Relevance 0
Induction of p53 leads to a reduction of Tcf4 mRNA and protein [166], and thus acts to decrease the Wnt/?
Negative_regulation (decrease) of Positive_regulation (Induction) of p53
6) Confidence 0.06 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.53 Pain Relevance 0

General Comments

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