INT101992

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Context Info
Confidence 0.81
First Reported 2000
Last Reported 2011
Negated 3
Speculated 9
Reported most in Body
Documents 413
Total Number 423
Disease Relevance 258.23
Pain Relevance 36.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
endothelial cells 19
fibroblast 10
macrophages 10
plasma 9
platelet 8
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3231 100.00 Very High Very High Very High
Inflammation 2768 100.00 Very High Very High Very High
chemokine 774 100.00 Very High Very High Very High
endometriosis 444 100.00 Very High Very High Very High
antagonist 330 100.00 Very High Very High Very High
Nerve growth factor 317 100.00 Very High Very High Very High
COX2 152 100.00 Very High Very High Very High
Arthritis 239 99.84 Very High Very High Very High
metalloproteinase 3087 99.80 Very High Very High Very High
ischemia 391 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3156 100.00 Very High Very High Very High
Endometriosis 574 100.00 Very High Very High Very High
Lymphatic System Cancer 430 99.96 Very High Very High Very High
Cryptococcus Infection 7 99.96 Very High Very High Very High
Apoptosis 1451 99.92 Very High Very High Very High
Hypoxia 1180 99.92 Very High Very High Very High
Papilledema 8 99.90 Very High Very High Very High
Cancer 11900 99.88 Very High Very High Very High
Ectopic Pregnancy 665 99.88 Very High Very High Very High
Lung Injury 83 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, our previous studies suggest that quantitative differences in secreted VEGF are not necessarily detectable in semi-quantitative immunohistochemical staining [6,8,9].
Localization (secreted) of VEGF
1) Confidence 0.81 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2279135 Disease Relevance 0.74 Pain Relevance 0
RESULTS: Capsaicin treatment resulted in enhanced VEGF protein secretion in malignant melanoma cells independent of IL-1beta and TNF-alpha.
Localization (secretion) of VEGF protein
2) Confidence 0.80 Published 2002 Journal J. Cancer Res. Clin. Oncol. Section Body Doc Link 12242509 Disease Relevance 0.10 Pain Relevance 0
The inhibitory effect of clonidine on the secretion of VEGF protein stimulated with IL-1beta was blocked by alpha(2)-ADR antagonists.
Localization (secretion) of VEGF protein
3) Confidence 0.80 Published 2009 Journal Graefes Arch. Clin. Exp. Ophthalmol. Section Body Doc Link 19011889 Disease Relevance 0 Pain Relevance 0
This CDS is able to release a number of cytokines including VEGF.
Localization (release) of VEGF associated with cytokine
4) Confidence 0.78 Published 2004 Journal Eur J Dermatol Section Abstract Doc Link 15246943 Disease Relevance 0.87 Pain Relevance 0.17
Malignant plasma cells can secrete various cytokines, including VEGF, basic fibroblast growth factor (bFGF), and hepatocyte growth factor (HGF), all known for their pro-angiogenic activity [42].
Localization (secrete) of VEGF in HGF associated with malignant neoplastic disease and cytokine
5) Confidence 0.77 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.40 Pain Relevance 0.05
It has been shown that MM cells are capable of secreting VEGF in response to Interleukin-6 (IL-6) stimulation; in response to that VEGF stimulation microvascular endothelial cells and bone marrow stromal cells secrete in turn IL-6, a potent growth factor for malignant plasma cells, thus closing a paracrine loop [43].
Localization (secreting) of VEGF in stromal cells associated with malignant neoplastic disease and multiple myeloma
6) Confidence 0.77 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.42 Pain Relevance 0.05
This could be explained at least partially by the release of VEGF from extracellular matrix through hyperoxia-induced proteolytic cleavage [33,34].
Localization (release) of VEGF in cleavage associated with hyperoxia
7) Confidence 0.77 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.64 Pain Relevance 0
In the present study, we investigated the release of VEGF, and the expression and distribution of VEGF and its receptors in the lung during the early onset of ALI induced by intestinal ischemia-reperfusion (IIR), a well-established model of extrapulmonary ARDS [20,21].
Spec (investigated) Localization (release) of VEGF in lung associated with cv general 4 under development, ischemia and adult respiratory distress syndrome
8) Confidence 0.77 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 1.41 Pain Relevance 0.12
Although animals in this study were ventilated with low tidal volume, we cannot exclude the contribution of mechanical factors to the release of VEGF [37], or an addictive effect between MV and hyperoxia.
Localization (release) of VEGF associated with hyperoxia
9) Confidence 0.77 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.58 Pain Relevance 0
We hypothesized that, in the early stage of lung injury, the release of VEGF from alveolar epithelial cells and leukocytes induced by acute inflammatory response may increase the vascular permeability and contribute to the formation of interstitial edema in the lung, whereas reduced VEGF and its receptors in alveolar epithelial cells due to tissue damage may lead to cell death.
Localization (release) of VEGF in leukocytes associated with lung injury, inflammatory response, edema and death
10) Confidence 0.77 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 1.50 Pain Relevance 0.08
Additional migration of monocytes is facilitated by the secretion of several growth factors including VEGF, bFGF and MCP-1 (monocyte chemoattractant protein 1).
Localization (secretion) of VEGF in monocytes
11) Confidence 0.77 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.98 Pain Relevance 0.11
Lastly, there may be specialized organs with higher VEGF production rates which, if separately partitioned from our normal compartment, may lessen the burden on skeletal muscle for VEGF production (i.e., VEGF release from tissue to blood, whether via lymph or vascular permeability).
Localization (release) of VEGF in blood
12) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.08 Pain Relevance 0.10
Moreover, interstitial proteolytic clearance of soluble or matrix-bound VEGF – e.g., plasmin- and matrix metalloproteinase (MMP)-mediated cleavage of VEGF165 and the respective release of VEGF110 and VEGF113 fragments [95], [146], as well as the intrinsic protein degradation rate of VEGF [147] – was not considered in the current model.
Localization (release) of VEGF113 in cleavage associated with metalloproteinase
13) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.28 Pain Relevance 0.17
Moreover, interstitial proteolytic clearance of soluble or matrix-bound VEGF – e.g., plasmin- and matrix metalloproteinase (MMP)-mediated cleavage of VEGF165 and the respective release of VEGF110 and VEGF113 fragments [95], [146], as well as the intrinsic protein degradation rate of VEGF [147] – was not considered in the current model.
Localization (release) of VEGF110 in cleavage associated with metalloproteinase
14) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.28 Pain Relevance 0.17
Adjustments to the internalization flows of VEGF could significantly alter the secretion flows of VEGF needed to maintain the same steady-state interstitial VEGF concentrations, and in turn significantly shift the tissue flow balance on Fig. 4, such that interstitial VEGF might acquire acute sensitivity to transport parameters, as well as to depletory ligand-trapping by sVEGFR1, against our current findings.
Localization (secretion) of VEGF
15) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
0), the steady-state plasma and interstitial free VEGF concentrations ([V]pl, [V]IS) were mapped out as functions of total VEGF-secretion rates from the normal tissue and calf compartments (qTotalVEGF,Normal and qTotalVEGF,Calf), where the individual isoforms VEGF121 and VEGF165 were secreted at a ratio of 1?
Localization (secreted) of VEGF121 in plasma
16) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
Co-expression of COX-2 and VEGF in all consecutive sections of inflamed pulps could be suggestive of a possible release of VEGF via a COX-2-dependent pathway.
Spec (possible) Localization (release) of VEGF
17) Confidence 0.76 Published 2007 Journal J Endod Section Abstract Doc Link 17185121 Disease Relevance 0.08 Pain Relevance 0.08
This VEGF immunolocalization is consistent with the stimulation of angiogenesis and the morphogenesis and differentiation of chondrocytes.
Localization (immunolocalization) of VEGF in chondrocytes
18) Confidence 0.75 Published 2003 Journal Arch. Oral Biol. Section Abstract Doc Link 12648555 Disease Relevance 0.35 Pain Relevance 0.43
The immunolocalisation of VEGF in the articular cartilage of sheep mandibular condyles.
Localization (immunolocalisation) of VEGF in articular cartilage
19) Confidence 0.75 Published 2003 Journal J Craniomaxillofac Surg Section Title Doc Link 12914710 Disease Relevance 0.26 Pain Relevance 0.08
RESULTS: VEGF was found to be localised predominantly to the proliferative and maturing layers of chondrocytes in the condylar fibrocartilage of the temporomandibular joints.
Localization (localised) of VEGF in temporomandibular joints
20) Confidence 0.75 Published 2003 Journal J Craniomaxillofac Surg Section Body Doc Link 12914710 Disease Relevance 0 Pain Relevance 0

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