INT101994

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Context Info
Confidence 0.50
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 1.24
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Nrg1) extracellular space (Nrg1) cell morphogenesis (Nrg1)
plasma membrane (Nrg1) cytoplasm (Nrg1)
Anatomy Link Frequency
neuronal 1
radial 1
brain 1
cleavage 1
Schwann cell 1
Nrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
conotoxin 1 99.68 Very High Very High Very High
Neurotransmitter 12 96.68 Very High Very High Very High
Central nervous system 9 96.12 Very High Very High Very High
Pain 1 93.96 High High
Peripheral nervous system 10 84.32 Quite High
Demyelination 6 79.16 Quite High
Angina 1 75.44 Quite High
anesthesia 3 74.76 Quite High
analgesia 1 74.28 Quite High
tolerance 1 69.96 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 1 98.80 Very High Very High Very High
Necrosis 2 97.84 Very High Very High Very High
Pain 1 93.96 High High
Cognitive Disorder 13 90.72 High High
Demyelinating Disease 7 79.16 Quite High
Emergencies 1 78.00 Quite High
Angina 1 75.44 Quite High
Alzheimer's Dementia 23 72.96 Quite High
Cancer 96 68.08 Quite High
Schizophrenia 17 59.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrate that stimulating Type III Nrg1 activates a PtdIns 3K signaling pathway and that PtdIns 3K and Akt activity are required for increased surface expression of ?
Positive_regulation (stimulating) of Nrg1
1) Confidence 0.50 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.05
Stimulation of Type III Nrg1 back signaling elicits a transcriptional response mediated by the Nrg1 intracellular domain (Bao et al., 2003, 2004).
Positive_regulation (Stimulation) of Nrg1
2) Confidence 0.50 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
Nrg1 activation of ErbB signaling regulates the levels of several ion channels, including subtypes of neuronal nicotinic acetylcholine receptors (nAChRs; Yang et al., 1998; Liu et al., 2001; Kawai et al., 2002; Chang and Fischbach, 2006), N-methyl-d-aspartic acid receptors (Ozaki et al., 1997; Gu et al., 2005), ?
Positive_regulation (activation) of Nrg1 in neuronal
3) Confidence 0.46 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0.11 Pain Relevance 0.05
At the molecular level, BACE1-/- brain, when compared to wild type brain, accumulated uncleaved NRG1 and exhibited reduced levels of NRG1 cleavage fragments, findings consistent with a role for BACE1 in the proteolysis of NRG1 [114, 115].
Positive_regulation (accumulated) of NRG1 in brain
4) Confidence 0.38 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.09 Pain Relevance 0.24
Full-length neuregulin-1 was increased and its cleavage product was decreased in the CNS of Bace1-null mice.
Positive_regulation (increased) of neuregulin-1 in cleavage
5) Confidence 0.34 Published 2006 Journal Nat. Neurosci. Section Abstract Doc Link 17099708 Disease Relevance 0.17 Pain Relevance 0.13
The pathways activated by established Schwann cell signals, such as cAMP and neuregulin, are actively being clarified as exemplified by the work on GPR126 and NF-?
Positive_regulation (activated) of neuregulin in Schwann cell
6) Confidence 0.30 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0.34 Pain Relevance 0.17
Increased expression of BLBP in the presence of NRG1 is erbB3/4 and Pi3K dependent
Positive_regulation (presence) of NRG1
7) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
Together, these results indicate that NRG1 via activation of erbB3/erbB4 receptors and Pi3K induces a realignment of vimentin+ radial glia (see also Figure 8).


Positive_regulation (activation) of NRG1 in radial
8) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
Production of HWTX-I by this method has the major advantages of high efficiency and low cost.
Positive_regulation (Production) of HWTX-I
9) Confidence 0.01 Published 2009 Journal Protein Expr. Purif. Section Abstract Doc Link 19217942 Disease Relevance 0 Pain Relevance 0.34
This transduction involves activation of Type I and Type II IFN receptors, receptor-associated JAK/TYK (tyrosine kinase) kinases and eventually activation and nuclear translocation of STAT1.
Positive_regulation (activation) of Type I
10) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.13 Pain Relevance 0
Despite this, in some cases elevations in the serum levels of cardiac troponin T and I are not associated with a final diagnosis of cardiac necrosis.
Positive_regulation (elevations) of and I associated with necrosis
11) Confidence 0.01 Published 2002 Journal Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology Section Abstract Doc Link 11926033 Disease Relevance 0.40 Pain Relevance 0.08

General Comments

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