INT1020

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 109
Total Number 110
Disease Relevance 44.86
Pain Relevance 16.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BCHE) extracellular region (BCHE) endoplasmic reticulum (BCHE)
enzyme binding (BCHE)
Anatomy Link Frequency
plasma 11
muscle 4
brain 3
body 3
heart 2
BCHE (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 96 100.00 Very High Very High Very High
Pain 74 100.00 Very High Very High Very High
antidepressant 25 99.98 Very High Very High Very High
tricyclic antidepressant 17 99.96 Very High Very High Very High
Dopamine 34 99.92 Very High Very High Very High
Nicotine 28 99.86 Very High Very High Very High
Multiple sclerosis 143 99.84 Very High Very High Very High
local anesthetic 11 99.84 Very High Very High Very High
Calcium channel 11 99.78 Very High Very High Very High
Endep 14 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 108 100.00 Very High Very High Very High
Pain 91 100.00 Very High Very High Very High
Disease 1113 99.96 Very High Very High Very High
Poisoning 519 99.92 Very High Very High Very High
Neurological Disease 21 99.92 Very High Very High Very High
Alzheimer's Dementia 95 99.90 Very High Very High Very High
Demyelinating Disease 157 99.84 Very High Very High Very High
Myocardial Infarction 19 99.84 Very High Very High Very High
Respiratory Failure 30 99.74 Very High Very High Very High
Language Disorders 9 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum pseudocholinesterase activity, dibucaine number and fluoride number were obtained, revealing markedly decreased pseudocholinesterase activity and dibucaine number, with an only slightly decreased fluoride number, consistent with homozygous type E1a atypical pseudocholinesterase.
Negative_regulation (decreased) of pseudocholinesterase in E1a
1) Confidence 0.59 Published 1995 Journal Indiana Med Section Abstract Doc Link 7650363 Disease Relevance 0.33 Pain Relevance 0.09
Such an effect, which has been described for cholinesterase inhibitors like neostigmine and donepezil, would explain the prolonged effect of succinylcholine.
Negative_regulation (inhibitors) of cholinesterase
2) Confidence 0.59 Published 2003 Journal Rev Esp Anestesiol Reanim Section Abstract Doc Link 12712872 Disease Relevance 0.15 Pain Relevance 0.08
Procaine showed competitive inhibition of serum cholinesterase, whereas for most anesthetics a mixed type of inhibition was observed.
Negative_regulation (inhibition) of cholinesterase
3) Confidence 0.59 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3675616 Disease Relevance 0 Pain Relevance 0.30
The serum cholinesterase was inhibited by all those compounds, their relative potencies being proportional to their octanol/water partition coefficients.
Negative_regulation (inhibited) of cholinesterase
4) Confidence 0.59 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3675616 Disease Relevance 0 Pain Relevance 0.35
Inhibition of human serum and rabbit muscle cholinesterase by local anesthetics.
Negative_regulation (Inhibition) of cholinesterase in muscle associated with local anesthetic
5) Confidence 0.59 Published 1987 Journal Biochem. Pharmacol. Section Title Doc Link 3675616 Disease Relevance 0 Pain Relevance 0.38
In humans, decreased levels of butyrylcholinesterase (BChE) (EC 3.1.1.8) have been associated with sustained effects of cocaine and life-threatening complications.
Negative_regulation (decreased) of BChE associated with cocaine
6) Confidence 0.59 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9266811 Disease Relevance 0.35 Pain Relevance 0.37
Antidepressants inhibit human acetylcholinesterase and butyrylcholinesterase activity.
Negative_regulation (inhibit) of butyrylcholinesterase associated with antidepressant
7) Confidence 0.58 Published 2002 Journal Biochim. Biophys. Acta Section Title Doc Link 12009429 Disease Relevance 0 Pain Relevance 1.00
Oropharyngeal muscle weakness caused by sarin-mediated cholinesterase inhibition was strongly suspected as the cause of hot spring water aspiration.
Negative_regulation (inhibition) of cholinesterase in muscle associated with muscle weakness
8) Confidence 0.58 Published 1998 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 9656677 Disease Relevance 1.16 Pain Relevance 0.11
Facilitatory nicotine receptors are present which are activated by applied nicotine or by blocking cholinesterase.
Negative_regulation (blocking) of cholinesterase associated with nicotine
9) Confidence 0.58 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11521162 Disease Relevance 0 Pain Relevance 0.32
These irreversible inhibitors of cholinesterase produce three well-recognised clinical entities: the initial cholinergic phase, which is a medical emergency often requiring management in an intensive care unit; the intermediate syndrome, during which prolonged ventilatory care is necessary; and delayed polyneuropathy.
Negative_regulation (inhibitors) of cholinesterase associated with neuropathy, emergencies and syndrome
10) Confidence 0.58 Published 1999 Journal Anaesthesia Section Abstract Doc Link 10540097 Disease Relevance 0.48 Pain Relevance 0
As for RBC cholinesterase (Table 7), the significant predictors are, again, years of pesticide use (p = 0.037) and health symptoms reported in the survey (p = 0.029). the number of years using pesticides gives an index of the length and possible extent of exposure, which has been shown to lower RBC cholinesterase levels.
Negative_regulation (lower) of cholinesterase
11) Confidence 0.57 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.24 Pain Relevance 0
It should be noted, however, that RBC cholinesterase is more difficult to measure and is depressed more slowly than plasma cholinesterase.
Negative_regulation (depressed) of cholinesterase in plasma
12) Confidence 0.57 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.07 Pain Relevance 0.03
Rivastigmine (Exelon®, Novartis Basel—Switzerland) is a slowly reversible inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), while donepezil (Aricept®, Pfizer, New York, USA) and galantamine (Reminyl®, Janssen, New Jersey,USA) show no functional inhibition of BuChE, and are considered AChE-selective, rapidly-reversible inhibitors.
Negative_regulation (inhibitor) of ChE
13) Confidence 0.57 Published 2007 Journal Clinical Interventions in Aging Section Abstract Doc Link PMC2684084 Disease Relevance 0.82 Pain Relevance 0
Inhibition of brain butyrylcholinesterase (BuChE) represents a new drug target for AD treatment.
Negative_regulation (Inhibition) of butyrylcholinesterase in brain associated with disease
14) Confidence 0.53 Published 2006 Journal J. Alzheimers Dis. Section Abstract Doc Link 16988481 Disease Relevance 0.59 Pain Relevance 0.09
The butyrylcholinesterase-blocking activity of the test substances decreased in the following order: bupivacaine>amethocaine>procaine>RU-1148.
Negative_regulation (decreased) of butyrylcholinesterase
15) Confidence 0.52 Published 2003 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 14631501 Disease Relevance 0 Pain Relevance 0.24
Thus, muscle relaxation can be achieved safely with a succinylcholine infusion in patients with decreased plasma cholinesterase activity if neuromuscular function is closely monitored.
Negative_regulation (decreased) of cholinesterase in plasma
16) Confidence 0.51 Published 1981 Journal Can Anaesth Soc J Section Abstract Doc Link 7284894 Disease Relevance 0.16 Pain Relevance 0
The arsenic-mediated decrease in cholinesterase activity in an animal model prompted us to examine the status of this enzyme in a human population that was exposed to arsenic.
Negative_regulation (decrease) of cholinesterase
17) Confidence 0.51 Published 2010 Journal Environ Health Section Body Doc Link PMC2911418 Disease Relevance 0.30 Pain Relevance 0
The decreased activity of cholinesterase was reported previously in rats that were injected with high doses of arsenic only for five days [34].
Negative_regulation (decreased) of cholinesterase
18) Confidence 0.51 Published 2010 Journal Environ Health Section Body Doc Link PMC2911418 Disease Relevance 0.38 Pain Relevance 0
These studies were used to set both the ARfD and the ADI for 6 compounds and the ARfD for another 7 compounds, and, with the exception of one ADI and one ARfD, they were all cholinesterase inhibitors.
Negative_regulation (inhibitors) of cholinesterase
19) Confidence 0.51 Published 2010 Journal Environ Health Section Body Doc Link PMC2931486 Disease Relevance 0.06 Pain Relevance 0
Most of the compounds were cholinesterase inhibitors (19 OPs and 3 carbamates).
Negative_regulation (inhibitors) of cholinesterase
20) Confidence 0.51 Published 2010 Journal Environ Health Section Body Doc Link PMC2931486 Disease Relevance 0 Pain Relevance 0

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