INT102019

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Context Info
Confidence 0.61
First Reported 2002
Last Reported 2009
Negated 4
Speculated 3
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 5.27
Pain Relevance 5.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
brain 8
hippocampus 4
shell 2
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 84 100.00 Very High Very High Very High
addiction 327 99.72 Very High Very High Very High
Nucleus accumbens 97 99.68 Very High Very High Very High
Hippocampus 134 99.40 Very High Very High Very High
Morphine 75 99.28 Very High Very High Very High
withdrawal 58 99.18 Very High Very High Very High
depression 34 98.48 Very High Very High Very High
Eae 17 92.64 High High
Desipramine 6 92.32 High High
drug abuse 45 91.48 High High
Disease Link Frequency Relevance Heat
Stress 151 100.00 Very High Very High Very High
Morphine Dependence 6 99.72 Very High Very High Very High
Cold Sores 64 98.86 Very High Very High Very High
Depression 44 98.48 Very High Very High Very High
Targeted Disruption 198 97.94 Very High Very High Very High
Body Weight 19 96.68 Very High Very High Very High
Appetite Loss 1 96.16 Very High Very High Very High
Anxiety Disorder 86 94.52 High High
Weight Loss 2 92.32 High High
Drug Dependence 67 91.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A transgenic animal model of depression with impaired glucocorticoid receptor function was used to investigate the effect of chronic antidepressant treatments on CREB expression in different brain areas.
Spec (investigate) Regulation (effect) of Gene_expression (expression) of CREB in brain associated with targeted disruption, antidepressant and depression
1) Confidence 0.61 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 11927185 Disease Relevance 0.45 Pain Relevance 0.55
Our findings suggest that life-long central glucocorticoid receptor dysfunction results in an altered sensitivity with respect to the effects of antidepressants on the expression of CREB.
Regulation (effects) of Gene_expression (expression) of CREB associated with antidepressant
2) Confidence 0.61 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 11927185 Disease Relevance 0.36 Pain Relevance 0.50
To our knowledge we are the first who investigated the effect of chronic psychosocial stress on CREB-driven gene expression in vivo.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of CREB-driven gene associated with stress
3) Confidence 0.61 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.94 Pain Relevance 0.16
More recently, through various advances in the field of molecular biology, novel techniques have arisen which confer alternative targeting of the Creb gene and control of expression.


Regulation (control) of Gene_expression (expression) of Creb
4) Confidence 0.44 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.21 Pain Relevance 0
Moreover, this overexpression period is unlikely to complement anything wrought upon CREB or pCREB expression by pharmacological or stressor methodology.
Regulation (wrought) of Gene_expression (expression) of CREB
5) Confidence 0.44 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.32 Pain Relevance 0.08
The balance of studies examining the impact of CREB knockdown in the context of addiction have done so with the CREB??
Spec (examining) Regulation (impact) of Gene_expression (knockdown) of CREB associated with addiction
6) Confidence 0.44 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0 Pain Relevance 0.05
Such observations were made consistently across discrete brain regions and other physiologically significant organs, revealing little correlation between CREB and pCREB levels.
Neg (little) Regulation (correlation) of Gene_expression (levels) of CREB in brain
7) Confidence 0.44 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.06 Pain Relevance 0.09
When detecting the expression of phosphorylated CREB (p-CREB) in the mouse hippocampus using Western blot and immunohistochemistry, we found CREB phosphorylation was clearly decreased following chronic morphine treatment.
Regulation (detecting) of Gene_expression (expression) of p-CREB in hippocampus associated with hippocampus and morphine
8) Confidence 0.39 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19289113 Disease Relevance 0.26 Pain Relevance 1.18
When detecting the expression of phosphorylated CREB (p-CREB) in the mouse hippocampus using Western blot and immunohistochemistry, we found CREB phosphorylation was clearly decreased following chronic morphine treatment.
Regulation (detecting) of Gene_expression (expression) of CREB in hippocampus associated with hippocampus and morphine
9) Confidence 0.39 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19289113 Disease Relevance 0.26 Pain Relevance 1.18
Moreover, this overexpression period is unlikely to complement anything wrought upon CREB or pCREB expression by pharmacological or stressor methodology.
Regulation (wrought) of Gene_expression (expression) of pCREB
10) Confidence 0.38 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.32 Pain Relevance 0.08
Drugs of abuse alter pCREB levels directly through kinase pathways, and CREB levels indirectly through gene expression systems; however, viral (HSV) overexpression systems increase CREB directly, without altering pCREB levels directly through endogenously occuring systems.
Neg (without) Regulation (altering) of Gene_expression (levels) of pCREB associated with cold sores
11) Confidence 0.38 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.25 Pain Relevance 0.04
Such observations were made consistently across discrete brain regions and other physiologically significant organs, revealing little correlation between CREB and pCREB levels.
Neg (little) Regulation (correlation) of Gene_expression (levels) of pCREB in brain
12) Confidence 0.38 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.06 Pain Relevance 0.09
Several studies examining the consequences of imipramine reported on inhibitory effects on CREB expression [38], [39] or CREB-regulated transcription[40].
Regulation (effects) of Gene_expression (expression) of CREB
13) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.42 Pain Relevance 0.31
Another attempt at regulating CREB expression in brain is the tetracycline transactivator system, whereby doxycycline in the drinking water is the “switch” that is coupled to the suppression of transgene expression.
Regulation (regulating) of Gene_expression (expression) of CREB in brain
14) Confidence 0.26 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.22 Pain Relevance 0.09
Almost unfailingly, natural or precipitated withdrawal from drugs of abuse leads to a dramatic alteration in the expression of nuclear pCREB.
Regulation (alteration) of Gene_expression (expression) of pCREB associated with withdrawal
15) Confidence 0.23 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.06 Pain Relevance 0.33
Recently, Barrot et al. (2002) reported that changes in CREB expression in the nucleus accumbens shell altered behavioral responses to emotional stimuli.
Regulation (changes) of Gene_expression (expression) of CREB in shell associated with nucleus accumbens
16) Confidence 0.19 Published 2005 Journal Mol Pain Section Body Doc Link PMC1079936 Disease Relevance 0.45 Pain Relevance 0.27
In accordance with the non-constitutive and inducible nature of ICER, specific overexpression or deletion of the gene did not cause any compensatory changes in the expression level of CREB or CREM isoforms.
Neg (not) Regulation (changes) of Gene_expression (expression) of CREB
17) Confidence 0.15 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.64 Pain Relevance 0.07

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