INT102020

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 13
Speculated 3
Reported most in Abstract
Documents 190
Total Number 193
Disease Relevance 57.31
Pain Relevance 59.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
brain 21
hippocampus 9
forebrain 8
neurons 7
nucleus accumbens 6
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 263 100.00 Very High Very High Very High
bDMF 71 100.00 Very High Very High Very High
adenocard 29 100.00 Very High Very High Very High
Morphine 423 99.92 Very High Very High Very High
ischemia 5 99.92 Very High Very High Very High
antidepressant 1110 99.84 Very High Very High Very High
addiction 1896 99.68 Very High Very High Very High
Hippocampus 965 99.68 Very High Very High Very High
Nucleus accumbens 764 99.68 Very High Very High Very High
Spinal cord 365 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 1340 100.00 Very High Very High Very High
Cold Sores 370 100.00 Very High Very High Very High
Neurodegenerative Disease 276 99.96 Very High Very High Very High
Stress 1143 99.92 Very High Very High Very High
Cv Unclassified Under Development 5 99.92 Very High Very High Very High
Anxiety Disorder 689 99.70 Very High Very High Very High
Herpes Simplex Virus 62 99.68 Very High Very High Very High
Death 285 99.58 Very High Very High Very High
Alzheimer's Dementia 95 99.44 Very High Very High Very High
Morphine Dependence 12 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While CREB is expressed in many cells throughout the brain, very little is known about the relative concentrations of CREB protein in various brain regions.
Neg (little) Gene_expression (expressed) of CREB in brain
1) Confidence 0.78 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 14622103 Disease Relevance 0 Pain Relevance 0.26
Chronic psychosocial stress for 25days stimulated CRE/CREB-directed luciferase expression in the hippocampus and other brain regions.
Gene_expression (expression) of CREB in brain associated with stress and hippocampus
2) Confidence 0.78 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20122921 Disease Relevance 0.63 Pain Relevance 0.77
Ketamine could suppress not only the place preference but also the phosphorylation of CREB produced by morphine, F9202 and F9204.
Gene_expression (produced) of CREB associated with ketamine and morphine
3) Confidence 0.78 Published 2003 Journal Cell Res. Section Abstract Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.93
Furthermore, the ability of morphine or CREB overexpression to up-regulate LC firing was blocked by knockout of the CREB target adenylyl cyclase 8.
Gene_expression (overexpression) of CREB associated with targeted disruption, locus ceruleus and morphine
4) Confidence 0.77 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20837544 Disease Relevance 0.10 Pain Relevance 1.20
Overexpression of a dominant negative CREB mutant blocked the increase in LC excitability induced by morphine- or cAMP-pathway activation.
Gene_expression (Overexpression) of CREB associated with locus ceruleus and morphine
5) Confidence 0.77 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20837544 Disease Relevance 0.08 Pain Relevance 1.20
This behavioral change was associated with a decrease in memory retrieval-induced expression of c-Fos and P-CREB in the lateral, basolateral, and central nuclei of the amygdala.
Gene_expression (expression) of P-CREB in lateral associated with amygdala
6) Confidence 0.77 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14583739 Disease Relevance 0.57 Pain Relevance 0.27
Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala.
Gene_expression (expression) of CREB in amygdala associated with anxiety disorder and amygdala
7) Confidence 0.77 Published 2004 Journal Neuropsychopharmacology Section Title Doc Link 14583739 Disease Relevance 0.51 Pain Relevance 0.27
Our findings suggest that life-long central glucocorticoid receptor dysfunction results in an altered sensitivity with respect to the effects of antidepressants on the expression of CREB.
Gene_expression (expression) of CREB associated with antidepressant
8) Confidence 0.77 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 11927185 Disease Relevance 0.36 Pain Relevance 0.47
Recent studies have demonstrated that long-term antidepressant treatment resulted in sustained activation of the cyclic adenosine 3',5'-monophosphate system and in increased expression of the transcription factor cAMP response element binding protein (CREB).
Gene_expression (expression) of CREB associated with adenocard and antidepressant
9) Confidence 0.77 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 11927185 Disease Relevance 0.44 Pain Relevance 0.50
Antidepressant treatment resulted in a neuroanatomically and animal specific expression pattern of CREB.
Gene_expression (expression) of CREB associated with antidepressant
10) Confidence 0.77 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 11927185 Disease Relevance 0.39 Pain Relevance 0.53
A transgenic animal model of depression with impaired glucocorticoid receptor function was used to investigate the effect of chronic antidepressant treatments on CREB expression in different brain areas.
Gene_expression (expression) of CREB in brain associated with targeted disruption, antidepressant and depression
11) Confidence 0.77 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 11927185 Disease Relevance 0.44 Pain Relevance 0.55
Chronic social stress significantly increased (by 45 to 120%) CRE/CREB-driven gene expression measured as luciferase activity in several brain regions.
Gene_expression (expression) of CREB-driven gene in brain associated with stress
12) Confidence 0.77 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1855984 Disease Relevance 0.82 Pain Relevance 0.26
To our knowledge we are the first who investigated the effect of chronic psychosocial stress on CREB-driven gene expression in vivo.
Gene_expression (expression) of CREB-driven gene associated with stress
13) Confidence 0.77 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.93 Pain Relevance 0.16
Therefore CRE/CREB-directed regulation of gene transcription cannot be determined by measuring simply CREB phosphorylation but rather by determining expression of a CRE/CREB-driven gene product which requires the generation of transgenic animals carrying a reporter gene.
Gene_expression (expression) of CREB-driven gene associated with targeted disruption
14) Confidence 0.77 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.30 Pain Relevance 0.16
Several studies examining the consequences of imipramine reported on inhibitory effects on CREB expression [38], [39] or CREB-regulated transcription[40].
Gene_expression (expression) of CREB
15) Confidence 0.77 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.41 Pain Relevance 0.31
Thus, the in vivo consequences of increased CREB expression so far appear not consistent.
Gene_expression (expression) of CREB
16) Confidence 0.77 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.25 Pain Relevance 0.45
In contrast, Nibuya et al.[41] found an increased CREB expression after chronic imipramine.
Gene_expression (expression) of CREB
17) Confidence 0.77 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.34 Pain Relevance 0.34
The pCMV-CREB vector constitutively expresses the human wild-type (wt) CREB protein and the pCMV-CREB133 vector expresses a mutant variant of the human CREB protein that contains a serine to alanine mutation corresponding to amino acid 133.
Gene_expression (expresses) of CREB
18) Confidence 0.76 Published 2006 Journal Mol Pain Section Body Doc Link PMC1459854 Disease Relevance 0.10 Pain Relevance 0.04
The overexpression of dominant-negative CREB or genetic deletion of CREB leads to reduced survival of sympathic/cerebellar neurons and progressive neurodegeneration in postnatal forebrains, while the overexpression of CREB supports neuronal survival [5-9].
Gene_expression (overexpression) of CREB in forebrains
19) Confidence 0.76 Published 2006 Journal Mol Pain Section Body Doc Link PMC1459854 Disease Relevance 0.53 Pain Relevance 0.28
Inhibition of CREB activity impaired behavioral performance in various memory tests across different species, while the overexpression of CREB facilitated long-term memory [2,3].
Gene_expression (overexpression) of CREB
20) Confidence 0.76 Published 2006 Journal Mol Pain Section Body Doc Link PMC1459854 Disease Relevance 0.35 Pain Relevance 0.17

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