INT102021

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 66
Total Number 67
Disease Relevance 24.04
Pain Relevance 23.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
brain 20
nucleus accumbens 8
neurons 8
cortex 6
lateral 4
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 105 100.00 Very High Very High Very High
bDMF 70 100.00 Very High Very High Very High
adenocard 16 100.00 Very High Very High Very High
Morphine 152 99.92 Very High Very High Very High
ischemia 5 99.92 Very High Very High Very High
long-term potentiation 271 99.88 Very High Very High Very High
antidepressant 523 99.78 Very High Very High Very High
analgesia 1 99.76 Very High Very High Very High
Hippocampus 347 99.68 Very High Very High Very High
Nucleus accumbens 330 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cold Sores 148 99.98 Very High Very High Very High
Cv Unclassified Under Development 5 99.92 Very High Very High Very High
Targeted Disruption 479 99.84 Very High Very High Very High
Death 159 99.82 Very High Very High Very High
Stress 364 99.76 Very High Very High Very High
Alzheimer's Dementia 84 99.72 Very High Very High Very High
Herpes Simplex Virus 24 99.68 Very High Very High Very High
Anxiety Disorder 167 99.50 Very High Very High Very High
Depression 427 99.36 Very High Very High Very High
Apoptosis 403 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic psychosocial stress for 25days stimulated CRE/CREB-directed luciferase expression in the hippocampus and other brain regions.
Positive_regulation (stimulated) of Gene_expression (expression) of CREB in brain associated with stress and hippocampus
1) Confidence 0.70 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20122921 Disease Relevance 0.63 Pain Relevance 0.78
Furthermore, the ability of morphine or CREB overexpression to up-regulate LC firing was blocked by knockout of the CREB target adenylyl cyclase 8.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CREB associated with targeted disruption, locus ceruleus and morphine
2) Confidence 0.69 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20837544 Disease Relevance 0.10 Pain Relevance 1.20
Overexpression of a dominant negative CREB mutant blocked the increase in LC excitability induced by morphine- or cAMP-pathway activation.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of CREB associated with locus ceruleus and morphine
3) Confidence 0.69 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20837544 Disease Relevance 0.08 Pain Relevance 1.20
This behavioral change was associated with a decrease in memory retrieval-induced expression of c-Fos and P-CREB in the lateral, basolateral, and central nuclei of the amygdala.
Positive_regulation (induced) of Gene_expression (expression) of P-CREB in lateral associated with amygdala
4) Confidence 0.69 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14583739 Disease Relevance 0.57 Pain Relevance 0.27
Recent studies have demonstrated that long-term antidepressant treatment resulted in sustained activation of the cyclic adenosine 3',5'-monophosphate system and in increased expression of the transcription factor cAMP response element binding protein (CREB).
Positive_regulation (resulted) of Gene_expression (expression) of CREB associated with adenocard and antidepressant
5) Confidence 0.69 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 11927185 Disease Relevance 0.44 Pain Relevance 0.50
Recent studies have demonstrated that long-term antidepressant treatment resulted in sustained activation of the cyclic adenosine 3',5'-monophosphate system and in increased expression of the transcription factor cAMP response element binding protein (CREB).
Positive_regulation (increased) of Gene_expression (expression) of CREB associated with adenocard and antidepressant
6) Confidence 0.69 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 11927185 Disease Relevance 0.44 Pain Relevance 0.50
Thus, the in vivo consequences of increased CREB expression so far appear not consistent.
Positive_regulation (increased) of Gene_expression (expression) of CREB
7) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.25 Pain Relevance 0.45
In contrast, Nibuya et al.[41] found an increased CREB expression after chronic imipramine.
Positive_regulation (increased) of Gene_expression (expression) of CREB
8) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.34 Pain Relevance 0.34
Inhibition of CREB activity impaired behavioral performance in various memory tests across different species, while the overexpression of CREB facilitated long-term memory [2,3].
Positive_regulation (overexpression) of Gene_expression (overexpression) of CREB
9) Confidence 0.68 Published 2006 Journal Mol Pain Section Body Doc Link PMC1459854 Disease Relevance 0.35 Pain Relevance 0.17
The overexpression of dominant-negative CREB or genetic deletion of CREB leads to reduced survival of sympathic/cerebellar neurons and progressive neurodegeneration in postnatal forebrains, while the overexpression of CREB supports neuronal survival [5-9].
Positive_regulation (overexpression) of Gene_expression (overexpression) of CREB in forebrains
10) Confidence 0.68 Published 2006 Journal Mol Pain Section Body Doc Link PMC1459854 Disease Relevance 0.53 Pain Relevance 0.28
One such model is herpes simplex virus (HSV)-mediated overexpression of CREB in specific brain nuclei or, in order to gain a local knockdown of CREB, the dominant-negative isoform mCREB (mutant CREB).
Positive_regulation (overexpression) of Gene_expression (overexpression) of CREB in brain associated with cold sores and herpes simplex virus
11) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.52 Pain Relevance 0.04
The balance of these studies have as a key endpoint the impact of (m)CREB overexpression upon the rewarding effects of cocaine or morphine [7, 17, 93], finding that CREB overexpression in the NAcc shell decreases drug reward whilst mCREB enhances drug reward, results that may also apply to natural rewards [7].
Positive_regulation (overexpression) of Gene_expression (overexpression) of CREB in shell associated with nucleus accumbens, morphine and cocaine
12) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.34 Pain Relevance 0.23
CREB overexpression was restricted to the nucleus of cells, predominantly in the striatum, although with some expression observed within the cingulate cortex and hippocampus.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CREB in cingulate cortex associated with hippocampus
13) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.13 Pain Relevance 0.14
Their model demonstrated that CREB overexpression in the brain had an inconsistent influence upon expression of other members of the CREB/ATF family (invariably downregulating though), paricularly CREM.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CREB in brain
14) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.14 Pain Relevance 0.13
The balance of these studies have as a key endpoint the impact of (m)CREB overexpression upon the rewarding effects of cocaine or morphine [7, 17, 93], finding that CREB overexpression in the NAcc shell decreases drug reward whilst mCREB enhances drug reward, results that may also apply to natural rewards [7].
Positive_regulation (overexpression) of Gene_expression (overexpression) of CREB in shell associated with nucleus accumbens, morphine and cocaine
15) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.36 Pain Relevance 0.23
Using recombinant Sindbis pseudovirions to drive constitutively active or dominant negative CREB overexpression in the NAcc, Dong and colleagues [29] demonstrated a recovery or further decrement in MSN excitability, respectively, in a rat model of cocaine bingeing.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CREB associated with nucleus accumbens and cocaine
16) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.40 Pain Relevance 0.39
The results demonstrate that blockade of CREB by overexpression of mCREB in transgenic mice or by viral expression of mCREB in the nucleus accumbens produces an antidepressant-like effect, whereas overexpression of CREB in transgenic mice results in the opposite phenotype.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CREB in nucleus accumbens associated with targeted disruption, nucleus accumbens and antidepressant
17) Confidence 0.68 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12486182 Disease Relevance 0.36 Pain Relevance 0.60
Using a microelectroporation technique to overexpress dominant negative mutant CREB (mCREB) in the adult mouse brain, we found that overexpression of mCREB in the forebrain cortex induced neuronal degeneration.
Positive_regulation (overexpression) of Gene_expression (overexpression) of mCREB in cortex
18) Confidence 0.59 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1459854 Disease Relevance 0 Pain Relevance 0.04
Interestingly, the overexpression of mCREB led to a significant loss of pyramidal neurons in the ACC (n = 10 mice; Fig. 1B).
Positive_regulation (overexpression) of Gene_expression (overexpression) of mCREB in pyramidal neurons associated with pyramidal cell and anterior cingulate cortex
19) Confidence 0.59 Published 2006 Journal Mol Pain Section Body Doc Link PMC1459854 Disease Relevance 0.32 Pain Relevance 0.44
Using a microelectroporation technique to overexpress dominant negative mutant CREB (mCREB) in the adult mouse brain, we found that overexpression of mCREB in the forebrain cortex induced neuronal degeneration.
Positive_regulation (overexpress) of Neg (negative) Gene_expression (overexpress) of mCREB in cortex
20) Confidence 0.59 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1459854 Disease Relevance 0 Pain Relevance 0.04

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