INT102023

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2010
Negated 6
Speculated 0
Reported most in Body
Documents 51
Total Number 51
Disease Relevance 16.29
Pain Relevance 16.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
brain 8
hippocampus 2
neuronal 2
primary somatosensory cortex 1
forebrain 1
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 598 100.00 Very High Very High Very High
bDMF 64 99.98 Very High Very High Very High
addiction 489 99.92 Very High Very High Very High
Inflammation 76 99.92 Very High Very High Very High
Pain 41 99.92 Very High Very High Very High
Nucleus accumbens 213 99.68 Very High Very High Very High
Hippocampus 362 99.60 Very High Very High Very High
Locus ceruleus 39 99.54 Very High Very High Very High
primary somatosensory cortex 3 99.50 Very High Very High Very High
Morphine 124 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 714 100.00 Very High Very High Very High
Convulsion 21 99.98 Very High Very High Very High
Anxiety Disorder 457 99.96 Very High Very High Very High
Drug Dependence 107 99.92 Very High Very High Very High
Cold Sores 93 98.86 Very High Very High Very High
Neurodegenerative Disease 38 98.68 Very High Very High Very High
Depression 380 98.60 Very High Very High Very High
Weight Loss 1 98.56 Very High Very High Very High
INFLAMMATION 79 98.48 Very High Very High Very High
Urological Neuroanatomy 16 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They could all significantly stimulate CREB phosphorylation and maintained for a long time without affecting total CREB protein levels.
Neg (without) Regulation (affecting) of CREB
1) Confidence 0.62 Published 2003 Journal Cell Res. Section Abstract Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.71
Altered regulation of CREB by chronic antidepressant administration in the brain of transgenic mice with impaired glucocorticoid receptor function.
Regulation (regulation) of CREB in brain associated with targeted disruption and antidepressant
2) Confidence 0.61 Published 2002 Journal Neuropsychopharmacology Section Title Doc Link 11927185 Disease Relevance 0.39 Pain Relevance 0.43
This discrepancy between CREB phosphorylation and transcriptional activity has been reported before in the visual cortex [22] and the hippocampus [23] leading to the assumption, that additional mechanisms regulating CREB activity must be present.
Regulation (regulating) of CREB in hippocampus associated with hippocampus
3) Confidence 0.61 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.18 Pain Relevance 0.21
This supports the notion that for comprehensive characterization of an effect on CREB activity it is not sufficient to determine only phosphorylation of CREB but rather its impact on gene expression.
Regulation (effect) of CREB
4) Confidence 0.61 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.18 Pain Relevance 0
The results showed that F9202, F9204 or morphine, which could induce CPP, enhanced CREB phosphorylation and the expression of CaMKIV in hippocampus from CPP mice without affecting total CREB protein level.
Neg (without) Regulation (affecting) of CREB in hippocampus associated with hippocampus and morphine
5) Confidence 0.61 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.70
A major downfall of this system, however, is the time lapse (seven to fourteen days) required to drive corresponding alteration in gene expression, a critical feature regarding (m/K)CREB cytological (dys)regulation.
Regulation (regulation) of CREB
6) Confidence 0.60 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.06 Pain Relevance 0.08
In contrast, numerous studies have suggested that alterations in CREB levels per se following cross-temporal drug abuse seem to occur unpredictably, if at all.
Regulation (alterations) of CREB associated with drug abuse
7) Confidence 0.60 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.33 Pain Relevance 0.25
The collective in situ and immunoblotting data indicated that CREB and/or activated CREB are regulated by various drugs of abuse within brain regions implicated in addiction.
Regulation (regulated) of CREB in brain associated with addiction
8) Confidence 0.60 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.22 Pain Relevance 0.34
The collective in situ and immunoblotting data indicated that CREB and/or activated CREB are regulated by various drugs of abuse within brain regions implicated in addiction.
Regulation (regulated) of CREB in brain associated with addiction
9) Confidence 0.60 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.22 Pain Relevance 0.34
Several kinase cascades regulate CREB function in the CNS [1,9], these include the cAMP signaling pathway and Ca2+-calmodulin-dependent protein kinase pathway.
Regulation (regulate) of CREB
10) Confidence 0.53 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.73 Pain Relevance 0.34
Drugs of abuse alter pCREB levels directly through kinase pathways, and CREB levels indirectly through gene expression systems; however, viral (HSV) overexpression systems increase CREB directly, without altering pCREB levels directly through endogenously occuring systems.
Regulation (alter) of pCREB associated with cold sores
11) Confidence 0.52 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.32 Pain Relevance 0.07
Molecular changes including adaptive modifications of the transcription factor CREB are produced during drug dependence in many regions of the brain, including the locus coeruleus (LC), but the molecular mechanisms involving CREB within these regions have remained controversial.
Regulation (involving) of CREB in locus coeruleus associated with drug dependence, addiction and locus ceruleus
12) Confidence 0.45 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15029152 Disease Relevance 0.43 Pain Relevance 0.44
Thus, changes in the transcriptional activity of CREB and of its gene product BDNF depend not only on the brain region but also on the type of stress and its duration.
Regulation (changes) of CREB in brain associated with stress
13) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.91 Pain Relevance 0.32
As CBP is a crucial cofactor in mediating phosphorylation-dependent CREB activity, enhanced levels of CBP might reflect increased CREB phosphorylation.
Regulation (dependent) of CREB
14) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.68 Pain Relevance 0.14
However, the activity of CREB, e.g. its phosphorylation, or its effects in transactivating transcription due to imipramine treatment was not determined in this study.
Regulation (effects) of CREB
15) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.26 Pain Relevance 0.38
The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception.
Regulation (impact) of CREB associated with nociception and inflammation
16) Confidence 0.44 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 17692820 Disease Relevance 0.70 Pain Relevance 0.50
Drugs of abuse alter pCREB levels directly through kinase pathways, and CREB levels indirectly through gene expression systems; however, viral (HSV) overexpression systems increase CREB directly, without altering pCREB levels directly through endogenously occuring systems.
Regulation (alter) of CREB associated with cold sores
17) Confidence 0.44 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.32 Pain Relevance 0.07
The main design behind such mutants is to induce disruption of all central CREB isoforms through targeting of the 10th Creb1 exon.
Regulation (targeting) of Creb1
18) Confidence 0.44 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.21 Pain Relevance 0
We examined if RACK1 is involved in the mechanism of drug addiction by regulating CREB in mouse hippocampus and prefrontal cortex.
Regulation (regulating) of CREB in cortex associated with drug dependence, addiction and hippocampus
19) Confidence 0.42 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.26 Pain Relevance 0.73
Together, these findings provide direct evidence that prolonged exposure to morphine induces homeostatic plasticity intrinsic to LC neurons, involving up-regulation of the cAMP-CREB signaling pathway, which then enhances LC neuronal excitability.
Regulation (regulation) of cAMP-CREB in neuronal associated with neuronal excitability, locus ceruleus and morphine
20) Confidence 0.39 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20837544 Disease Relevance 0.09 Pain Relevance 1.10

General Comments

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