INT102033

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 4.14
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ppard) lipid binding (Ppard) cell proliferation (Ppard)
nucleus (Ppard) DNA binding (Ppard) lipid metabolic process (Ppard)
Ppard (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 22 99.24 Very High Very High Very High
COX-2 inhibitor 10 98.72 Very High Very High Very High
Analgesic 1 97.08 Very High Very High Very High
COX2 12 96.64 Very High Very High Very High
aspirin 3 92.00 High High
cOX1 3 87.28 High High
addiction 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Necrosis 1 98.08 Very High Very High Very High
Apoptosis 17 97.88 Very High Very High Very High
Death 3 94.48 High High
INFLAMMATION 8 89.88 High High
Cancer 14 86.76 High High
Ovarian Cancer 8 83.16 Quite High
Colon Cancer 9 78.08 Quite High
Stress 4 77.32 Quite High
Lymphatic System Cancer 1 61.36 Quite High
Renal Cancer 1 60.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study, for the first time, shows that whereas PPARdelta can be a target of COX-1, extracellular signal-regulated kinase is a potential target of PPARdelta.
Negative_regulation (target) of PPARdelta
1) Confidence 0.37 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17545608 Disease Relevance 0.91 Pain Relevance 0.30
Sulindac sulfide inhibited PPARdelta protein expression and PPARdelta transcriptional activity.
Negative_regulation (inhibited) of PPARdelta
2) Confidence 0.32 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409426 Disease Relevance 0.77 Pain Relevance 0.47
Suppression of PPARdelta leads to reduced 14-3-3e and hence a decline in Bad sequestration, resulting in an increased Bad-induced apoptosis via the mitochondrial death pathway.
Negative_regulation (Suppression) of PPARdelta associated with apoptosis and death
3) Confidence 0.29 Published 2009 Journal Methods Mol. Biol. Section Abstract Doc Link 19347284 Disease Relevance 0.78 Pain Relevance 0.27
NSAIDs and COXIBs block PGI(2) production, thereby reducing PPARdelta DNA binding activity and abrogating 14-3-3e upregulation.
Negative_regulation (reducing) of PPARdelta associated with cinod
4) Confidence 0.29 Published 2009 Journal Methods Mol. Biol. Section Abstract Doc Link 19347284 Disease Relevance 0.62 Pain Relevance 0.29
Some of the COX-independent mechanisms for NSAIDs and selective COX-2 inhibitors include activation of protein kinase G, inhibition of NF-kappa B activation, downregulation of the antiapoptotic protein Bcl-XL, inhibition of PPAR delta, and activation of PPAR gamma.
Negative_regulation (inhibition) of PPAR delta associated with cinod and cox-2 inhibitor
5) Confidence 0.26 Published 2003 Journal Prog Exp Tumor Res Section Abstract Doc Link 12795055 Disease Relevance 0.47 Pain Relevance 0.53
Inhibition of PPARdelta activity may contribute to the renal papillary necrosis associated with analgesic and/or NSAID use.
Negative_regulation (Inhibition) of PPARdelta associated with necrosis, analgesic and cinod
6) Confidence 0.25 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11927585 Disease Relevance 0.57 Pain Relevance 0.63

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox