INT102034

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 3.97
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ppard) lipid binding (Ppard) cell proliferation (Ppard)
nucleus (Ppard) DNA binding (Ppard) lipid metabolic process (Ppard)
Anatomy Link Frequency
skin 2
colon 1
RMIC 1
NUC-1 1
Ppard (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 28 99.48 Very High Very High Very High
cINOD 26 98.32 Very High Very High Very High
aspirin 3 92.96 High High
Analgesic 3 92.16 High High
cOX1 5 89.00 High High
Inflammation 81 84.88 Quite High
agonist 58 82.48 Quite High
COX-2 inhibitor 1 64.64 Quite High
Bile 40 5.00 Very Low Very Low Very Low
antagonist 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 29 100.00 Very High Very High Very High
Colon Cancer 4 100.00 Very High Very High Very High
Ovarian Cancer 24 99.60 Very High Very High Very High
Stress 20 98.88 Very High Very High Very High
Cancer 52 98.16 Very High Very High Very High
INFLAMMATION 92 98.12 Very High Very High Very High
Death 6 94.24 High High
Targeted Disruption 50 86.40 High High
Disease 43 78.08 Quite High
Diabetes Mellitus 19 76.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is currently unclear whether ligand activation of PPARbeta either inhibits or potentiates carcinogenesis.
Spec (whether) Positive_regulation (activation) of PPARbeta
1) Confidence 0.69 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16418176 Disease Relevance 0.09 Pain Relevance 0.44
Additionally, results from these studies do not support the hypothesis that ligand activation of PPARbeta by COX-derived metabolites potentiates chemically induced skin carcinogenesis.
Positive_regulation (activation) of PPARbeta in skin
2) Confidence 0.69 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16418176 Disease Relevance 0 Pain Relevance 0.19
Results from these studies demonstrate that inhibition of COX2 by dietary sulindac in mouse skin can effectively inhibit chemically induced skin carcinogenesis, and suggest that the mechanism underlying this chemopreventive effect is independent of PPARbeta.
Neg (independent) Positive_regulation (independent) of PPARbeta in skin associated with cox2
3) Confidence 0.50 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16418176 Disease Relevance 0.05 Pain Relevance 0.30
We found that EOC cells express high levels of PPARdelta, and neutralizing PPARdelta function reduces tumor growth in vivo.
Positive_regulation (levels) of PPARdelta associated with cancer and ovarian cancer
4) Confidence 0.41 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17545608 Disease Relevance 1.09 Pain Relevance 0.32
Cyclooxygenase inhibitors induce colon cancer cell apoptosis Via PPARdelta --> 14-3-3epsilon pathway.
Positive_regulation (induce) of PPARdelta in colon associated with colon cancer, cox2 and apoptosis
5) Confidence 0.34 Published 2009 Journal Methods Mol. Biol. Section Title Doc Link 19347284 Disease Relevance 0.74 Pain Relevance 0.40
, or NR1C1) is a nuclear hormone receptor activated by a structurally diverse array of synthetic chemicals known as peroxisome proliferators.
Positive_regulation (activated) of nuclear hormone receptor
6) Confidence 0.24 Published 2010 Journal Nuclear Receptor Signaling Section Abstract Doc Link PMC2858266 Disease Relevance 0.43 Pain Relevance 0.10
These studies are consistent with a model whereby hypertonicity activates COX2-derived prostaglandin production, which promotes RMIC viability through PPARdelta.
Positive_regulation (promotes) of PPARdelta in RMIC associated with cox2
7) Confidence 0.22 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11927585 Disease Relevance 0.49 Pain Relevance 0.65
Hypertonic stress increased PGI2 synthesis 330% above base line and also activated a PPARdelta specific reporter (delta response element (DRE)) by 90% above base line.
Positive_regulation (activated) of PPARdelta associated with stress
8) Confidence 0.20 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11927585 Disease Relevance 0.56 Pain Relevance 0.61
, NUC-1, or FAAR) are activated by naturally occurring fatty acids and act as sensors
Positive_regulation (activated) of NUC-1 in NUC-1
9) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2276614 Disease Relevance 0 Pain Relevance 0.04
In cells with the ability to take up fatty acids, this LPA production pathway might have an important regulatory role through activation of the nuclear hormone receptor PPAR?.
Positive_regulation (activation) of nuclear hormone receptor
10) Confidence 0.05 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.53 Pain Relevance 0.11
The steroid and xenobiotic receptor (SXR) (also known as pregnane X receptor or PXR) is a nuclear hormone receptor activated by a diverse array of endogenous hormones, dietary steroids, pharmaceutical agents, and xenobiotic compounds.
Positive_regulation (activated) of nuclear hormone receptor
11) Confidence 0.03 Published 2009 Journal Nuclear Receptor Signaling Section Abstract Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0

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