INT102036

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 4.41
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bowel 1
Dre (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 30 100.00 Very High Very High Very High
positron emission tomography 8 99.76 Very High Very High Very High
agonist 16 99.72 Very High Very High Very High
Electroencephalography 23 99.28 Very High Very High Very High
Pain management 2 98.64 Very High Very High Very High
nerve block 2 97.84 Very High Very High Very High
COX2 7 93.84 High High
anesthesia 12 93.20 High High
cOX1 2 90.32 High High
cINOD 4 89.12 High High
Disease Link Frequency Relevance Heat
Epilepsy 69 100.00 Very High Very High Very High
Stress 4 98.88 Very High Very High Very High
Pain 19 98.20 Very High Very High Very High
Reprotox - General 1 87 96.32 Very High Very High Very High
Targeted Disruption 36 95.92 Very High Very High Very High
Cancer 8 93.84 High High
Convulsion 36 92.32 High High
Disease 18 84.92 Quite High
Prostate Cancer 1 84.40 Quite High
Benign Prostatic Hypertrophy 27 79.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: One-hundred patients undergoing DRE for prostate cancer screening answered an anonymous questionnaire regarding pain, urinary urgency and bowel urgency during DRE and its potential impact on future examination.
Positive_regulation (undergoing) of DRE in bowel
1) Confidence 0.59 Published 2008 Journal Arch. Esp. Urol. Section Body Doc Link 18972927 Disease Relevance 0 Pain Relevance 0
The aim was to identify possible drawbacks that could be overcome to increase DRE.
Positive_regulation (increase) of DRE
2) Confidence 0.51 Published 2008 Journal Int Braz J Urol Section Abstract Doc Link 18986560 Disease Relevance 0.17 Pain Relevance 0
A total of 100 patients who had elevated total prostate-specific antigen (tPSA) and/or abnormal digital rectal examination (DRE) were included in this study.
Spec (examination) Positive_regulation (elevated) of DRE
3) Confidence 0.40 Published 2003 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 14663473 Disease Relevance 0.39 Pain Relevance 0.92
After DRE, this figure increased to 91.5% (p < 0.001).
Positive_regulation (increased) of DRE
4) Confidence 0.37 Published 2008 Journal Int Braz J Urol Section Body Doc Link 18986560 Disease Relevance 0 Pain Relevance 0
Alternatively nurses could be taught to undertake DRE thereby further reducing clinician workload.
Positive_regulation (undertake) of DRE
5) Confidence 0.25 Published 2005 Journal BMC Urol Section Body Doc Link PMC544886 Disease Relevance 0.44 Pain Relevance 0.07
This audit suggests that Nurse Specialists need not be trained to perform DRE before the establishment of such clinics.
Positive_regulation (perform) of DRE
6) Confidence 0.25 Published 2005 Journal BMC Urol Section Body Doc Link PMC544886 Disease Relevance 0.56 Pain Relevance 0.08
The latter fragment alone does not have the transacting potential but substantially enhances activation of DRE by AhR–ligand complexes (Kasai et al. 2006b).
Positive_regulation (activation) of DRE
7) Confidence 0.24 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.41 Pain Relevance 0.04
However larger studies are required involving all the subgroups of patients to identify the subgroups of patients who will require DRE routinely.



Positive_regulation (require) of DRE
8) Confidence 0.23 Published 2005 Journal BMC Urol Section Abstract Doc Link PMC544886 Disease Relevance 0.35 Pain Relevance 0
Using the in vitro DRESSA bioassay (Kasai et al. 2004, 2005), we recently reported that cigarette smoke contains high levels of AhR agonists and strongly activates the AhR–DRE pathway (Kasai et al. 2006a).
Positive_regulation (activates) of DRE associated with agonist
9) Confidence 0.22 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.07 Pain Relevance 0.05
There may be a requirement of functional imaging techniques in a certain number of DRE like positron emission tomography (PET), single photon emission tomography, (SPECT)).
Positive_regulation (requirement) of DRE associated with epilepsy, positron emission tomography and imagery
10) Confidence 0.14 Published 2010 Journal Annals of Indian Academy of Neurology Section Abstract Doc Link PMC2924525 Disease Relevance 0.88 Pain Relevance 0.46
Therefore, there is a discrepancy between the in vitro binding to the DRE and the lack of transcriptional activation.
Positive_regulation (activation) of DRE
11) Confidence 0.02 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
In cases of a pre-operative elevated PSA or a suspicious DRE, a TRUS biopsy should be done.
Positive_regulation (elevated) of DRE
12) Confidence 0.02 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615329 Disease Relevance 0.57 Pain Relevance 0.17
Hypertonic stress increased PGI2 synthesis 330% above base line and also activated a PPARdelta specific reporter (delta response element (DRE)) by 90% above base line.
Positive_regulation (activated) of DRE associated with stress
13) Confidence 0.01 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11927585 Disease Relevance 0.57 Pain Relevance 0.63

General Comments

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