INT102044

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 4.76
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ERVW-1)
Anatomy Link Frequency
platelet 1
T cells 1
ERVW-1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 171 98.52 Very High Very High Very High
Migraine 7 98.44 Very High Very High Very High
Potency 20 81.80 Quite High
headache 13 80.16 Quite High
Central nervous system 22 77.24 Quite High
Angina 6 55.84 Quite High
cytokine 19 50.00 Quite Low
Pain 3 34.88 Quite Low
Inflammation 10 14.00 Low Low
cva 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 373 100.00 Very High Very High Very High
Headache 20 98.44 Very High Very High Very High
Adhesions 2 95.80 Very High Very High Very High
Viral Meningitis 21 91.16 High High
Dementia 18 90.48 High High
Infection 271 87.84 High High
Dengue 122 85.36 High High
Bites And Stings 2 77.00 Quite High
Disease 37 76.08 Quite High
Viral Infection 12 69.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, a long RNA antisense sequence targeting the HIV-1 envelope gene provided very strong inhibition of viral replication, but transduced cells did not exhibit a strong survival advantage in vitro.
Regulation (targeting) of env associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925957 Disease Relevance 1.01 Pain Relevance 0.04
Landau by introducing a frameshift mutation in the env gene of pNL4-3-luc+ [87].
Regulation (introducing) of env
2) Confidence 0.40 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.36 Pain Relevance 0
It is possible that the genetic changes resulting in an altered Env conformation that confers lower CD4 dependence, higher avidity for CD4 and increased fusogenicity, may also affect the interaction with certain, but not all, entry inhibitors, with the difference potentially being on changes on the accessibility of the key residues that interact with those inhibitors due to the conformational alterations.


Regulation (altered) of Env associated with addiction
3) Confidence 0.40 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.17 Pain Relevance 0.14
STUDY DESIGN: An assay targeting the envelope protein coding region was designed and evaluated for its specificity, detection limit, repeatability, and capacity to detect ZIKV isolates collected over a 40-year period from various African countries and hosts.
Regulation (targeting) of envelope protein
4) Confidence 0.27 Published 2008 Journal J. Clin. Virol. Section Body Doc Link 18674965 Disease Relevance 0 Pain Relevance 0
Cell surface-PDI has been found to act on transmembrane and surface-associated proteins, including the envelope protein of HIV-1, to cause its fusogenic conformation (Markovic et al, 2004) and integrins, to mediate platelet adhesion (Lahav et al, 2003).
Regulation (act) of envelope protein in platelet associated with acquired immune deficiency syndrome or hiv infection and adhesions
5) Confidence 0.26 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.33 Pain Relevance 0
There were 13 amino acid differences between the wild-type BR and SPL Env clones in V1/V2, 8 in V3 and 9 in V4, in addition to less numerous changes in more conserved Env regions.
Regulation (changes) of Env
6) Confidence 0.24 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.33 Pain Relevance 0.04
The high-dose IM vaccination regimen resulted in the induction of CD4+ T cells targeting Env in almost all volunteers using both ICS assays.
Regulation (targeting) of Env in T cells
7) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981570 Disease Relevance 0.13 Pain Relevance 0
Env responses were predominant in all groups (50–67%) with Gag/Pol responses observed most frequently in the high-dose IM group (40%).
Regulation (responses) of Env
8) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981570 Disease Relevance 0.50 Pain Relevance 0.21
Using a similar approach of chimeric proteins, the TM cytoplasmic domain has been found to be involved in the modulation of intracellular envelope trafficking [163].
Regulation (modulation) of envelope
9) Confidence 0.14 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0 Pain Relevance 0
The mean values of LNG, ENV-AREA and REC-AREA in the EC session in the migraine group were significantly greater than those in the controls (P < 0.05, Mann-Whitney rank sum test).
Regulation (values) of ENV-AREA associated with migraine
10) Confidence 0.01 Published 2002 Journal Psychiatry Clin. Neurosci. Section Abstract Doc Link 11929575 Disease Relevance 1.24 Pain Relevance 1.03
The envelope protein is involved in the main biological functions and is responsible for binding and transport into host cells.
Regulation (responsible) of envelope protein
11) Confidence 0.00 Published 2009 Journal Transfusion Medicine (Oxford, England) Section Body Doc Link PMC2713854 Disease Relevance 0.69 Pain Relevance 0

General Comments

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