INT102071

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.50
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Myc) DNA binding (Myc) protein complex (Myc)
cytoplasm (Myc) pigmentation (Myc) chromosome organization (Myc)
Anatomy Link Frequency
nerve 2
M cell 2
epithelial cells 2
epidermis 2
Myc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 1 99.68 Very High Very High Very High
cytokine 8 96.16 Very High Very High Very High
fibrosis 1 86.32 High High
Central nervous system 2 70.12 Quite High
cva 2 14.52 Low Low
agonist 32 5.00 Very Low Very Low Very Low
Kinase C 26 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
positron emission tomography 8 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 83 99.14 Very High Very High Very High
Benign Prostatic Hypertrophy 8 96.42 Very High Very High Very High
Bullous Skin Disease 608 93.68 High High
Hypertrophy 2 92.00 High High
Targeted Disruption 39 90.76 High High
Adhesions 103 90.68 High High
Cancer 118 89.60 High High
Fibrosis 1 86.32 High High
Stress 17 81.16 Quite High
Lymphatic System Cancer 53 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Our data thus indicate that NS-398 causes an increase in APC expression and a decrease in c-myc expression.


Negative_regulation (decrease) of Gene_expression (expression) of c-myc
1) Confidence 0.57 Published 2002 Journal J. Gastroenterol. Section Body Doc Link 11931531 Disease Relevance 0 Pain Relevance 0
In addition, c-myc mRNA expression was clearly decreased in the group of rats treated with both AOM and NS-398 compared with the level in the group of rats treated with AOM alone.
Negative_regulation (decreased) of Gene_expression (expression) of c-myc
2) Confidence 0.57 Published 2002 Journal J. Gastroenterol. Section Body Doc Link 11931531 Disease Relevance 0 Pain Relevance 0
In the epidermis, Rac 1 was found not to be crucial for maintaining epithelial integrity but for stem cell differentiation, presumably via negative regulation of c-Myc expression (Benitah et al. 2005; Chrostek et al. 2006).
Negative_regulation (regulation) of Gene_expression (expression) of c-Myc in epidermis
3) Confidence 0.57 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.65 Pain Relevance 0
Depsipeptide has been shown to induce differentiation, cause G1 and G2/M cell cycle arrest and apoptosis, increase expression of p21 and cyclin E, decrease expression of cyclin D1 and c-myc, and cause hypophosphorylation of Rb (Sandor et al 2000; Picardo et al 2004; Piekarz et al 2004; Piekarz and Bates 2004).
Negative_regulation (decrease) of Gene_expression (expression) of c-myc in M cell associated with apoptosis
4) Confidence 0.57 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721288 Disease Relevance 0.63 Pain Relevance 0
Moreover, following obstruction of the bladders of animal models and patients with BPH, there were acute increases in the expression of bFGF (7), the transcription factors, upstream binding factor, c-Jun, and cyclins E and C (8), nerve growth factor (9), N-ras and c-myc (10), and decreased expression of TGF-beta 1 (7).
Negative_regulation (decreased) of Gene_expression (expression) of c-myc in nerve associated with benign prostatic hypertrophy and nerve growth factor
5) Confidence 0.42 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.60 Pain Relevance 0.08
Furthermore, these mice had a 24-hr lag in the hepatic expression of the G1/S checkpoint regulator genes cyclin D1 (Ccnd1) and c-myc and increased expression of the interleukin-1?
Negative_regulation (hepatic) of Gene_expression (expression) of c-myc
6) Confidence 0.41 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.92 Pain Relevance 0.14
A target gene of Lef-1/plakoglobin signalling is c-Myc, the expression of which was inhibited in keratinocytes but enhanced in transformed rat kidney epithelial cells (Kolligs et al. 2000; Kolly et al. 2007; Williamson et al. 2006).
Negative_regulation (inhibited) of Gene_expression (expression) of c-Myc in epithelial cells
7) Confidence 0.41 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.26 Pain Relevance 0
In addition, c-Myc and PCNA levels were also reduced (Fig 5A).
Negative_regulation (reduced) of Gene_expression (levels) of c-Myc
8) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.44 Pain Relevance 0

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