INT102073

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 6.09
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
Anatomy Link Frequency
colon 4
liver 2
DCs 2
APC (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 10 100.00 Very High Very High Very High
rheumatoid arthritis 87 98.80 Very High Very High Very High
Inflammation 15 79.20 Quite High
fibrosis 12 7.40 Low Low
cytokine 15 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 209 100.00 Very High Very High Very High
Cancer 146 100.00 Very High Very High Very High
Hepatocellular Cancer 103 99.84 Very High Very High Very High
Rheumatoid Arthritis 89 98.80 Very High Very High Very High
Liver Cancer 20 98.52 Very High Very High Very High
INFLAMMATION 18 97.12 Very High Very High Very High
Colon Cancer 48 94.60 High High
Hepatitis Virus Infection 8 90.36 High High
Necrosis 3 89.04 High High
Pancreatic Cancer 1 73.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because promoter methylation is significantly enhanced in HCC compared to that of non-tumor samples, and APC expression is also significantly reduced in liver cancer cells, higher degrees of promoter methylation of the APC gene seem to be responsible for the reduced APC protein expression in HCC.
Regulation (responsible) of Gene_expression (expression) of APC in liver associated with liver cancer, cancer, familial adenomatous polyposis and hepatocellular cancer
1) Confidence 0.45 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.77 Pain Relevance 0
Previous studies focused on epigenetic changes of the APC promoter but did not evaluate the APC protein expression in HCC (Lee et al. 2003; Yang et al. 2003; Esteller et al. 2001; Yu et al. 2002).
Neg (not) Regulation (evaluate) of Gene_expression (expression) of APC associated with hepatocellular cancer and familial adenomatous polyposis
2) Confidence 0.45 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.81 Pain Relevance 0
Another report has shown that deregulated APC/?
Regulation (deregulated) of Gene_expression (/) of APC
3) Confidence 0.28 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 0.99 Pain Relevance 0
The aim of this study was to examine the effects of NSAIDs on the expression of the tumor suppressor APC gene and the c-myc oncogene in the colons of rats treated with a colon-specific carcinogen, azoxymethane (AOM).
Regulation (effects) of Gene_expression (expression) of APC in colon associated with cancer and cinod
4) Confidence 0.18 Published 2002 Journal J. Gastroenterol. Section Abstract Doc Link 11931531 Disease Relevance 0.29 Pain Relevance 0.38
Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane.
Regulation (Effects) of Gene_expression (expression) of APC in colon
5) Confidence 0.15 Published 2002 Journal J. Gastroenterol. Section Title Doc Link 11931531 Disease Relevance 0.28 Pain Relevance 0.37
While the APC function of PB pDCs was less efficient than that of PB myeloid DCs, RA SF pDCs efficiently activated resting allogeneic PB T cells, and high levels of IFN-?
Regulation (efficient) of Gene_expression (function) of APC in DCs associated with rheumatoid arthritis
6) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065313 Disease Relevance 0.97 Pain Relevance 0.40

General Comments

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