INT102076

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Context Info
Confidence 0.22
First Reported 2002
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 10.00
Pain Relevance 3.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (DST) endoplasmic reticulum (DST) cytoplasm (DST)
cell adhesion (DST) cell motility (DST) nucleus (DST)
Anatomy Link Frequency
DMH 2
neurons 2
plasma 1
spinal cord 1
brainstem 1
DST (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 112 100.00 Very High Very High Very High
Spinal cord 38 99.64 Very High Very High Very High
gABA 10 99.60 Very High Very High Very High
Cholecystokinin 296 99.34 Very High Very High Very High
Glutamate receptor 2 98.76 Very High Very High Very High
fibrosis 3 98.64 Very High Very High Very High
Neuropathic pain 20 98.28 Very High Very High Very High
Inflammation 81 97.88 Very High Very High Very High
Central grey 4 96.48 Very High Very High Very High
parabrachial 10 95.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperplasia 6 99.16 Very High Very High Very High
Fibrosis 3 98.64 Very High Very High Very High
Neuropathic Pain 34 98.28 Very High Very High Very High
Fever 54 97.96 Very High Very High Very High
INFLAMMATION 90 97.88 Very High Very High Very High
Schizophrenia 332 97.54 Very High Very High Very High
Cv General 2 Under Development 36 97.24 Very High Very High Very High
Increased Venous Pressure Under Development 91 97.16 Very High Very High Very High
Atherosclerotic Plaque 22 97.00 Very High Very High Very High
Urological Neuroanatomy 24 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, as suggested by studies in intact rats, neurons in the DMH, including those projecting to the PVN, are regulated by tonic GABA(A) and non-NMDA glutamate receptor-mediated synaptic transmission.
Regulation (regulated) of DMH in neurons associated with gaba and glutamate receptor
1) Confidence 0.22 Published 2003 Journal Brain Res. Section Abstract Doc Link 12967719 Disease Relevance 0 Pain Relevance 0.38
Of the 1949 medicated schizophrenia patients, 504 (25.9%) were classified as non-suppressors, suggesting that antipsychotic medications themselves had little effect on DST results.


Neg (little) Regulation (effect) of DST associated with schizophrenia
2) Confidence 0.20 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 0.80 Pain Relevance 0.03
The reason for this increase remained unsolved, because no difference in patient-related plasma hemoglobin levels, serum gamma-GT, pre-albumin, or in DST was detected.
Neg (no) Regulation (difference) of DST in plasma
3) Confidence 0.15 Published 2010 Journal Crit Care Section Body Doc Link PMC2945119 Disease Relevance 0.97 Pain Relevance 0.04
Since antipsychotic medication may affect DST results (Tandon et al., 1991), medicated and drug-free patients were analysed separately.
Spec (may) Regulation (affect) of DST
4) Confidence 0.12 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 1.00 Pain Relevance 0.04
Bilateral electrocoagulation of the PVH or DMH, but not of the POA, prevented this cold-seeking response.
Regulation (electrocoagulation) of DMH in POA
5) Confidence 0.11 Published 2006 Journal PLoS ONE Section Abstract Doc Link PMC1762328 Disease Relevance 0.96 Pain Relevance 0.15
Electrocoagulation of the DMH blocked both cold-seeking behavior (P?
Regulation (Electrocoagulation) of DMH
6) Confidence 0.11 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762328 Disease Relevance 1.12 Pain Relevance 0.03
Neither did electrocoagulation of DMH affect cold-seeking behaviors caused by heat exposure and menthol nor warmth-seeking behaviors caused by cold exposure and RTX (data not shown).
Regulation (electrocoagulation) of DMH associated with increased venous pressure under development
7) Confidence 0.11 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762328 Disease Relevance 1.28 Pain Relevance 0.04
DMH-treatment also had no influence on serum IGFBP-2 levels in both genotypes and at both time points measured (Fig. 1B).
Neg (no) Regulation (influence) of DMH
8) Confidence 0.03 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 0.83 Pain Relevance 0
The recurrent basic changes in myohyperplastic plaque (smooth muscle cell hyperplasia, fibrosis, proteoglycan accumulation with atheroma and/or calcification) explain the various intimal aspects amongst different plaques and different tracts of the same plaque (Fig. 4).
Regulation (changes) of plaque in smooth muscle cell associated with fibrosis, calcification, atherosclerotic plaque and hyperplasia
9) Confidence 0.02 Published 2004 Journal Cardiovasc Ultrasound Section Body Doc Link PMC539295 Disease Relevance 1.08 Pain Relevance 0.10
The DMH is an important leptin target, as it expresses both leprb mRNA and protein [18,19].
Regulation (target) of DMH
10) Confidence 0.02 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.17 Pain Relevance 0.18
In this study, the synergistic effect of CCK and CART peptide on food intake targeted hypothalamic PVN and DMH and NTS, which suggested that CART peptide might act as a mediator of the leptin anorexigenic effect both in the hypothalamus and brainstem.
Regulation (targeted) of DMH in brainstem associated with medulla and cholecystokinin
11) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.22 Pain Relevance 0.64
An identical set of mice was used for determination of Fos immunoreactivity in NTS, PVN, and DMH.
Regulation (immunoreactivity) of DMH associated with medulla
12) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.10
Our results suggest a strong regulation of both, CATS and CATX, in the spinal cord of an animal model of neuropathic pain.
Regulation (regulation) of CATX in spinal cord associated with neuropathic pain and spinal cord
13) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.75 Pain Relevance 0.56
While CATS-immunopositive neurons were rare, CATX-immunoreactivity was found in nearly all neurons (Fig. 1B, D, H) and only in few small cells (Fig. 1D, J).
Regulation (immunoreactivity) of CATX in neurons
14) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.35 Pain Relevance 0.46
Exposure of animals to an ambient temperature of 5 degrees C induced Fos immunoreactivity in the magnocellular paraventricular nucleus (mPVN) and the dorsomedial region of the hypothalamus (DMH).
Regulation (immunoreactivity) of DMH in DMH
15) Confidence 0.01 Published 2002 Journal Brain Res. Section Abstract Doc Link 11931855 Disease Relevance 0.28 Pain Relevance 0.13
In this study, the synergistic effect of CCK and CART peptide on food intake targeted hypothalamic PVN and DMH and NTS, which suggested that CART peptide might act as a mediator of the leptin anorexigenic effect both in the hypothalamus and brainstem.
Regulation (targeted) of DMH in hypothalamus associated with medulla and cholecystokinin
16) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.22 Pain Relevance 0.64

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