INT10208

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Context Info
Confidence 0.57
First Reported 1987
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 13.98
Pain Relevance 8.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
hypothalamus 6
Semen 6
brain 4
hippocampus 4
frontal cortex 4
Htr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 23 100.00 Very High Very High Very High
Raphe 8 100.00 Very High Very High Very High
Anterior cingulate 2 99.84 Very High Very High Very High
fluoxetine 41 99.72 Very High Very High Very High
depression 82 99.68 Very High Very High Very High
opiate 2 99.62 Very High Very High Very High
Hippocampus 24 99.58 Very High Very High Very High
antidepressant 16 99.50 Very High Very High Very High
sSRI 5 98.80 Very High Very High Very High
Opioid 4 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 144 100.00 Very High Very High Very High
Depression 84 99.68 Very High Very High Very High
Urological Neuroanatomy 20 99.68 Very High Very High Very High
Anxiety Disorder 4 98.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abstinence from U-50,488H, a kappa-opiate receptor agonist, decreases the binding of [3H]DPAT to 5-HT1A receptors in the hypothalamus of the rat.
Negative_regulation (decreases) of 5-HT1A Binding (binding) of in hypothalamus associated with agonist and opiate
1) Confidence 0.57 Published 1992 Journal Neuropharmacology Section Title Doc Link 1470300 Disease Relevance 0 Pain Relevance 0.70
In the I to II regions of the frontal cortex, N.s. and H.p. also reversed the CMS-induced decrease in 5-HT1A receptor binding, and even showed a significant increase in 5-HT1A receptor binding compared to the F treatment group (N.s. vs.
Negative_regulation (reversed) of 5-HT1A Binding (binding) of in frontal cortex associated with stress and urological neuroanatomy
2) Confidence 0.57 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 1.56 Pain Relevance 0.46
Nelumbinis Semen reverses a decrease in 5-HT1A receptor binding induced by chronic mild stress, a depression-like symptom.
Negative_regulation (decrease) of 5-HT1A Binding (binding) of in Semen associated with stress and depression
3) Confidence 0.57 Published 2004 Journal Arch. Pharm. Res. Section Title Doc Link 15554266 Disease Relevance 1.05 Pain Relevance 0.50
However, in the hypothalamus, all treatments reversed the CMS-induced decrease in 5-HT1A receptor binding.
Negative_regulation (reversed) of 5-HT1A Binding (binding) of in hypothalamus associated with stress
4) Confidence 0.57 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 1.30 Pain Relevance 0.36
In the CA2 and CA3 regions of the hippocampus, both N.s. and H.p. reversed the CMS-induced decrease in 5-HT1A receptor binding.
Negative_regulation (reversed) of 5-HT1A Binding (binding) of in hippocampus associated with stress and hippocampus
5) Confidence 0.57 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 1.66 Pain Relevance 0.47
The present study assessed if Nelumbinis Semen (N.s.) had an anti-depression effect through reversing a decrease in 5-HT1A receptor binding in rats with depression-like symptoms induced by chronic mild stress.
Negative_regulation (reversing) of 5-HT1A Binding (binding) of in Semen associated with stress and depression
6) Confidence 0.57 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 0.94 Pain Relevance 0.46
This reversal effect of N.s. on the decrease in 5-HT1A receptor binding in the frontal cortex, hippocampus and hypothalamus of rat brains was very similar to that of H.p, but different from that of F.
Negative_regulation (decrease) of 5-HT1A Binding (binding) of in brains associated with urological neuroanatomy and hippocampus
7) Confidence 0.57 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 1.26 Pain Relevance 0.35
The similar stimulus properties of 8-OHDPAT and the novel anxiolytics (buspirone, ipsapirone) are mirrored by the common abilities of these agents to selectively inhibit 5-HT1A binding and release punished responding.
Negative_regulation (inhibit) of 5-HT1A Binding (binding) of associated with anxiety disorder
8) Confidence 0.57 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2887435 Disease Relevance 0.34 Pain Relevance 0.40
In the I to II regions of the frontal cortex, N.s. and H.p. also reversed the CMS-induced decrease in 5-HT1A receptor binding, and even showed a significant increase in 5-HT1A receptor binding compared to the F treatment group (N.s. vs.
Negative_regulation (decrease) of 5-HT1A Binding (binding) of in frontal cortex associated with stress and urological neuroanatomy
9) Confidence 0.42 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 1.55 Pain Relevance 0.45
Fentanyl and sufentanil inhibit agonist binding to 5-HT1A receptors in membranes from the rat brain.
Negative_regulation (inhibit) of 5-HT1A Binding (binding) of in brain associated with agonist
10) Confidence 0.42 Published 1991 Journal Neuropharmacology Section Title Doc Link 1830134 Disease Relevance 0 Pain Relevance 0.45
However, in the hypothalamus, all treatments reversed the CMS-induced decrease in 5-HT1A receptor binding.
Negative_regulation (decrease) of 5-HT1A Binding (binding) of in hypothalamus associated with stress
11) Confidence 0.42 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 1.29 Pain Relevance 0.35
The present study assessed if Nelumbinis Semen (N.s.) had an anti-depression effect through reversing a decrease in 5-HT1A receptor binding in rats with depression-like symptoms induced by chronic mild stress.
Negative_regulation (decrease) of 5-HT1A Binding (binding) of in Semen associated with stress and depression
12) Confidence 0.42 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 0.94 Pain Relevance 0.46
In the CA2 and CA3 regions of the hippocampus, both N.s. and H.p. reversed the CMS-induced decrease in 5-HT1A receptor binding.
Negative_regulation (decrease) of 5-HT1A Binding (binding) of in hippocampus associated with stress and hippocampus
13) Confidence 0.42 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 1.64 Pain Relevance 0.47
In ED-VEH versus CON-VEH, 5-HT1A receptor binding was significantly reduced in anterior cingulate, motor cortex, ventral hippocampal CA1 and dorsal raphé; this was reversed by chronic FLX.
Negative_regulation (reduced) of 5-HT1A Binding (binding) of in ventral associated with anterior cingulate
14) Confidence 0.42 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19138691 Disease Relevance 0.22 Pain Relevance 0.40
These results show that adaptive desensitization of somatodendritic 5-HT1A autoreceptors within the dorsal raphe nucleus can already be detected after a 3-day treatment with selective serotonin reuptake inhibitors.
Negative_regulation (detected) of 5-HT1A Binding (desensitization) of in dorsal associated with ssri and raphe
15) Confidence 0.41 Published 1995 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7477436 Disease Relevance 0 Pain Relevance 0.77
Subsequent studies were performed in the additional presence of WAY100635 (100 nM) to prevent [3H]5-CT binding to residual, possibly, 5-HT1A sites.
Negative_regulation (prevent) of 5-HT1A Binding (binding) of
16) Confidence 0.41 Published 1998 Journal Neuropharmacology Section Abstract Doc Link 9886684 Disease Relevance 0 Pain Relevance 0.08
Acute treatment with the antidepressant fluoxetine internalizes 5-HT1A autoreceptors and reduces the in vivo binding of the PET radioligand [18F]MPPF in the nucleus raphe dorsalis of rat.
Negative_regulation (reduces) of 5-HT1A Binding (binding) of in nucleus associated with antidepressant, raphe and fluoxetine
17) Confidence 0.41 Published 2004 Journal J. Neurosci. Section Title Doc Link 15190115 Disease Relevance 0 Pain Relevance 0.56
Interestingly, the changes in [35S]GTPgammaS basal binding and on 5-HT1A receptors functionality were prevented by the concomitant administration of WAY100635.
Negative_regulation (prevented) of 5-HT1A Binding (binding) of
18) Confidence 0.41 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18809415 Disease Relevance 0 Pain Relevance 0.82
In ED-VEH versus CON-VEH, 5-HT1A receptor binding was significantly reduced in anterior cingulate, motor cortex, ventral hippocampal CA1 and dorsal raphé; this was reversed by chronic FLX.
Negative_regulation (reduced) of 5-HT1A in cortex Binding (binding) of in ventral associated with anterior cingulate
19) Confidence 0.14 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19138691 Disease Relevance 0.22 Pain Relevance 0.40

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