INT102080

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 6.91
Pain Relevance 7.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx3) Golgi apparatus (P2rx3)
Anatomy Link Frequency
neurons 4
neuronal 2
visceral 2
sensory neurons 1
nerve 1
P2rx3 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 17 99.74 Very High Very High Very High
agonist 117 99.44 Very High Very High Very High
Pain 142 99.28 Very High Very High Very High
Antinociceptive 3 99.00 Very High Very High Very High
Migraine 130 98.80 Very High Very High Very High
adenocard 22 98.52 Very High Very High Very High
Lasting pain 9 98.52 Very High Very High Very High
headache 49 98.44 Very High Very High Very High
Visceral pain 9 97.80 Very High Very High Very High
Inflammation 7 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 109 99.96 Very High Very High Very High
Pain 142 99.28 Very High Very High Very High
Migraine Disorders 91 98.80 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

9 97.80 Very High Very High Very High
INFLAMMATION 5 97.68 Very High Very High Very High
Disease 9 95.44 Very High Very High Very High
Nociception 59 94.36 High High
Headache 25 93.28 High High
Hyperalgesia 4 91.72 High High
Ganglion Cysts 216 80.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these results show that activation of P2X3 containing receptors plays a role in the transmission of inflammatory visceral pain.
Positive_regulation (activation) of P2X3 in visceral associated with visceral pain and inflammation
1) Confidence 0.67 Published 2002 Journal Pain Section Abstract Doc Link 11932066 Disease Relevance 0.32 Pain Relevance 0.60
Furthermore, 2'-(or-3')-O-(trinitrophenyl)adenosine 5'- tri-phosphate (TNP-ATP) potently (IC50=10 nM) blocked the functional activation of P2X3 receptors in vitro and attenuated acetic acid-induced visceral pain.
Positive_regulation (activation) of P2X3 in visceral associated with visceral pain and adenocard
2) Confidence 0.67 Published 2002 Journal Pain Section Abstract Doc Link 11932066 Disease Relevance 0.29 Pain Relevance 0.73
Thus, it seemed likely that the origin of the augmented P2X3 receptor activity of KI neurons might reside in a changed phosphorylation state of the intracellular protein domains.
Positive_regulation (augmented) of P2X3 in neurons
3) Confidence 0.64 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
In an in vivo model of mouse trigeminal pain, anti-NGF pretreatment suppressed responses evoked by P2X3 receptor activation.
Positive_regulation (activation) of P2X3 associated with pain
4) Confidence 0.52 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17670966 Disease Relevance 0.25 Pain Relevance 0.27
Specifically, we could observe upregulation of P2X3 in the transplants arguing that RET-independent markers are induced via the Runx1 pathway.
Positive_regulation (upregulation) of P2X3
5) Confidence 0.49 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0 Pain Relevance 0.21
This study demonstrates the utility of ASO approaches for validating gene targets in in vivo pain models and provides evidence for a role of P2X3 receptors in the pathophysiology of chronic pain.
Positive_regulation (role) of P2X3 associated with pain and lasting pain
6) Confidence 0.49 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223568 Disease Relevance 0.98 Pain Relevance 0.86
Thus, the antinociceptive effects of TNP-ATP appear to be mediated through activation of homomeric P2X3and/or heteromeric P2X2/3 receptors.
Positive_regulation (activation) of P2X3 associated with antinociceptive
7) Confidence 0.49 Published 2002 Journal Pain Section Abstract Doc Link 11932066 Disease Relevance 0.24 Pain Relevance 0.63
We showed that a subpopulation of P2X3 expressing neurons also expressed CaV2.1 channels, thus providing ample opportunity for their crosstalk.
Positive_regulation (subpopulation) of P2X3 in neurons
8) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.19 Pain Relevance 0.44
In four similar experiments application of the P2Y receptor agonist UTP to the colorectum also increased the nerve activity by 40 ± 3% in wildtype preparations and, to the greater extent of 76 ± 6%, in the P2X2/P2X3Dbl?
Positive_regulation (increased) of P2X2/P2X3Dbl in nerve associated with agonist
9) Confidence 0.45 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096651 Disease Relevance 0.15 Pain Relevance 0.08
The observation that UTP evoked a greater increase in pelvic afferent discharge in P2X2/P2X3Dbl?
Positive_regulation (increase) of P2X2/P2X3Dbl
10) Confidence 0.45 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096651 Disease Relevance 0.14 Pain Relevance 0.33
Thirdly, 5-HT evoked a greater increase in pelvic afferent discharge in the P2X2/P2X3Dbl?
Positive_regulation (increase) of P2X2/P2X3Dbl
11) Confidence 0.45 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096651 Disease Relevance 0.23 Pain Relevance 0.11
Although we observed unchanged activity of TRPV1 receptors in mutant mouse sensory neurons, we detected a significant increase in P2X3 receptor activity that was characterized by combining electrophysiological and molecular biology techniques.


Positive_regulation (increase) of P2X3 in sensory neurons
12) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.91 Pain Relevance 0.90
These results suggest that R192Q mutation in CaV2.1 channels conferred to KI trigeminal neurons a molecular phenotype with constitutively depressed serine phosphorylation of P2X3 receptors, together with upregulation of P2X3 receptor-mediated currents.
Positive_regulation (upregulation) of P2X3 in neurons
13) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
Because these purinergic nociceptors activate one major pain transducing mechanism of the trigeminovascular system [50], it is attractive to think that strong P2X3 receptor activation may facilitate ATP-dependent migraine headache [13,14].
Positive_regulation (activation) of P2X3 in nociceptors associated with pain, migraine, nociceptor and headache
14) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.90 Pain Relevance 1.09
The inverse correlation between P2X3 serine phosphorylation and P2X3 activity (i.e., reduced serine phosphorylation associated with enhanced P2X3 receptor function) suggests that P2X3 serine dephosphorylation could be an important molecular contributor to receptor operation, particularly in view of the fact that Cdk5 (a kinase associated with negative P2X3 receptor regulating function [26]) was less associated with P2X3 receptors in neuronal membranes of KI neurons.
Positive_regulation (enhanced) of P2X3 in neuronal
15) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.06 Pain Relevance 0.06
Despite anti-NGF treatment, CGRP could still enhance P2X3 receptor activity, indicating separate NGF- or CGRP-mediated mechanisms to upregulate P2X3 receptors.
Positive_regulation (enhance) of P2X3 associated with calcitonin gene-related peptide
16) Confidence 0.38 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17670966 Disease Relevance 0.35 Pain Relevance 0.34
Could P2X3 upregulation be an important component of migraine headache and to what extent do R192Q KI mice help our understanding of the disease process?
Positive_regulation (upregulation) of P2X3 associated with migraine, headache and disease
17) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.48 Pain Relevance 0.54
This would be revealed by an increase in the sensitivity of the MMC to inhibition by mecamylamine in P2X3 KO mice because it has been shown that P2X3 subunits are expressed by murine colonic myenteric neurons (Ruan and Burnstock, 2005).
Positive_regulation (increase) of P2X3 in neurons associated with targeted disruption
18) Confidence 0.35 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2858605 Disease Relevance 0.66 Pain Relevance 0.03
P2X3 was increased in the neuronal (bTUB+) population by the induction of Runx1 expression (Fig. 5A–C; p = 1.3 × 10?
Positive_regulation (increased) of P2X3 in neuronal
19) Confidence 0.29 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.24 Pain Relevance 0.04
Activation of P2X1 and P2X3 receptors results in desensitization, and ?
Positive_regulation (Activation) of P2X3
20) Confidence 0.03 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.05

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