INT102083

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Context Info
Confidence 0.72
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.31
Pain Relevance 4.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabra5) plasma membrane (Gabra5)
Anatomy Link Frequency
striatum 2
brain 1
diencephalons 1
cortex 1
hippocampus 1
Gabra5 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 28 99.96 Very High Very High Very High
Hippocampus 13 99.68 Very High Very High Very High
c fibre 1 99.36 Very High Very High Very High
Versed 14 98.68 Very High Very High Very High
qutenza 1 98.04 Very High Very High Very High
algogenic 1 97.56 Very High Very High Very High
isoflurane 9 97.44 Very High Very High Very High
Pyramidal cell 4 95.08 Very High Very High Very High
gABA 45 92.12 High High
Pain 5 91.28 High High
Disease Link Frequency Relevance Heat
Nociception 9 99.84 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

3 85.28 High High
Targeted Disruption 32 64.80 Quite High
Anxiety Disorder 4 35.28 Quite Low
Depression 8 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Respiratory Failure 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of GABAA receptor alpha4 subunit mRNA closely correlated with expression of c-fos-like protein.
Gene_expression (Expression) of GABAA receptor alpha4 subunit mRNA
1) Confidence 0.72 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16733821 Disease Relevance 0 Pain Relevance 0.42
Changes in expression of GABAA alpha4 subunit mRNA in the brain under anesthesia induced by volatile and intravenous anesthetics.
Gene_expression (expression) of GABAA alpha4 subunit mRNA in brain associated with anesthesia
2) Confidence 0.72 Published 2006 Journal Neurochem. Res. Section Title Doc Link 16733821 Disease Relevance 0 Pain Relevance 0.51
During deep anesthesia (which was estimated by loss of righting reflex) after administration of propofol, levels of GABAA receptor alpha4 subunit mRNA in the hippocampus, striatum and diencephalons were significantly greater than those observed after administration of pentobarbital, midazolam or GOI (5.0% isoflurane and 70% nitrous oxide in oxygen).
Gene_expression (levels) of GABAA receptor alpha4 subunit mRNA in striatum associated with anesthesia, versed, isoflurane and hippocampus
3) Confidence 0.56 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16733821 Disease Relevance 0 Pain Relevance 0.44
Under incomplete anesthesia, levels of GABAA receptor alpha4 subunit mRNA were significantly increased by midazolam in all brain regions, and were significantly increased by pentobarbital in the posterior cortex and striatum.
Gene_expression (levels) of GABAA receptor alpha4 subunit mRNA in cortex associated with anesthesia and versed
4) Confidence 0.56 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16733821 Disease Relevance 0 Pain Relevance 0.45
During deep anesthesia (which was estimated by loss of righting reflex) after administration of propofol, levels of GABAA receptor alpha4 subunit mRNA in the hippocampus, striatum and diencephalons were significantly greater than those observed after administration of pentobarbital, midazolam or GOI (5.0% isoflurane and 70% nitrous oxide in oxygen).
Gene_expression (levels) of GABAA receptor alpha4 subunit mRNA in diencephalons associated with anesthesia, versed, isoflurane and hippocampus
5) Confidence 0.19 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16733821 Disease Relevance 0 Pain Relevance 0.44
During deep anesthesia (which was estimated by loss of righting reflex) after administration of propofol, levels of GABAA receptor alpha4 subunit mRNA in the hippocampus, striatum and diencephalons were significantly greater than those observed after administration of pentobarbital, midazolam or GOI (5.0% isoflurane and 70% nitrous oxide in oxygen).
Gene_expression (levels) of GABAA receptor alpha4 subunit mRNA in hippocampus associated with anesthesia, versed, isoflurane and hippocampus
6) Confidence 0.19 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16733821 Disease Relevance 0 Pain Relevance 0.44
Under incomplete anesthesia, levels of GABAA receptor alpha4 subunit mRNA were significantly increased by midazolam in all brain regions, and were significantly increased by pentobarbital in the posterior cortex and striatum.
Gene_expression (levels) of GABAA receptor alpha4 subunit mRNA in striatum associated with anesthesia and versed
7) Confidence 0.19 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16733821 Disease Relevance 0 Pain Relevance 0.45
Research has focused on the P2X3 ligand-gated ion channel, as it is preferentially expressed on nociceptive C-fibers.
Gene_expression (expressed) of ligand-gated ion channel associated with nociception and c fibre
8) Confidence 0.18 Published 2002 Journal Pain Section Abstract Doc Link 11932066 Disease Relevance 0.10 Pain Relevance 0.55
The non-peptidergic subclass express the ATP-gated ion channel P2X3whereas both groups of C fibers express the capsaicin TRPV1 receptor.
Gene_expression (express) of ATP-gated ion channel associated with qutenza
9) Confidence 0.05 Published 2006 Journal Mol Pain Section Body Doc Link PMC1479315 Disease Relevance 0.12 Pain Relevance 0.57
Deletion of the alpha5 subunit results in the upregulation of otherwise in this celltype undetectable receptors containing the delta subunit that provide some small rescuing tonic inhibition.
Gene_expression (Deletion) of alpha5 subunit
10) Confidence 0.05 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.37

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