INT102106

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 48
Total Number 48
Disease Relevance 30.62
Pain Relevance 9.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
apoptotic cells 3
pore 2
embryos 1
retina 1
spinal cord 1
Bax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 36 99.98 Very High Very High Very High
Hippocampus 21 99.44 Very High Very High Very High
ischemia 427 98.32 Very High Very High Very High
Spinal cord 4 98.24 Very High Very High Very High
Inflammatory mediators 11 97.76 Very High Very High Very High
Infliximab 35 97.48 Very High Very High Very High
Etanercept 31 97.20 Very High Very High Very High
Pain 13 96.80 Very High Very High Very High
Dorsal horn 2 96.60 Very High Very High Very High
Inflammation 121 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 1083 100.00 Very High Very High Very High
Hypoxia 37 99.90 Very High Very High Very High
Colitis 37 99.32 Very High Very High Very High
Cancer 191 98.62 Very High Very High Very High
Retina Disease 204 98.32 Very High Very High Very High
Stress 189 98.16 Very High Very High Very High
INFLAMMATION 140 97.76 Very High Very High Very High
Colon Cancer 1 97.64 Very High Very High Very High
Glioblastoma 81 97.26 Very High Very High Very High
Death 269 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the intracellular level, prolonged morphine administration resulted in an upregulation of the proapoptotic caspase-3 and Bax proteins but a downregulation of the antiapoptotic Bcl-2 protein in the spinal cord dorsal horn.
Positive_regulation (upregulation) of Bax in spinal cord dorsal horn associated with dorsal horn, spinal cord and morphine
1) Confidence 0.67 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12196588 Disease Relevance 0.74 Pain Relevance 1.58
Like Fas-L, bax was also not detectable in controls (fig 3 A,B), but was increased in animals with colitis (fig. 3 C,D), especially in the crypt compartment.
Neg (not) Positive_regulation (increased) of bax associated with colitis
2) Confidence 0.67 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2452978 Disease Relevance 0.87 Pain Relevance 0.43
The results showed a significant increase in Bax immunoreactivity in all of the mentioned embryonic days (E9.5 to E13.5) and a significant decrease in Bcl-2 immunoreactivity at days E10.5 and E12.5 in morphine-treated groups compared with control.
Positive_regulation (increase) of Bax associated with morphine
3) Confidence 0.65 Published 2010 Journal J. Mol. Neurosci. Section Abstract Doc Link 19936637 Disease Relevance 0.20 Pain Relevance 0.68
Data analysis revealed that Bax/Bcl2 ratio was increased in all of the morphine-exposed groups.
Positive_regulation (increased) of Bax associated with morphine
4) Confidence 0.65 Published 2010 Journal J. Mol. Neurosci. Section Abstract Doc Link 19936637 Disease Relevance 0.20 Pain Relevance 0.74
Expressions of Bax and Bcl-2 at mRNA and protein levels were altered resulting in an increase in Bax : Bcl-2 ratio in apoptotic cells, which also exhibited overexpression of 80 kDa calpain and an increase in calpain-cleaved 145 kDa alpha-spectrin breakdown product.
Positive_regulation (increase) of Bax in apoptotic cells associated with apoptosis
5) Confidence 0.64 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17570061 Disease Relevance 1.63 Pain Relevance 0.22
Upregulation of Bax at the protein level is in agreement with in vitro and in vivo studies of retinal ischemia [1,19-21] as well as observations made after cerebral ischemia [15-17].
Positive_regulation (Upregulation) of Bax associated with cv general 4 under development, ischemia and retina disease
6) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.62 Pain Relevance 0.27
This underlined the importance of a time-related upregulation of the proapoptotic Bax and did not support a relevant role for Bak in this deleterious process.
Positive_regulation (upregulation) of Bax
7) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.56 Pain Relevance 0.22
Contrary to mRNA, Bax and Bcl-xL protein levels were significantly upregulated 24 h post I/R (1.511±0.148 and 1.402±0.188, p<0.05, respectively).
Positive_regulation (upregulated) of Bax
8) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.08 Pain Relevance 0
When stimulated, Bax is activated and translocated to the mitochondria, where it forms pores in the outer membrane by binding with the adenine nucleotide translocator leading to permeabilization of the mitochondria [11-13].
Positive_regulation (activated) of Bax in pores
9) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.76 Pain Relevance 0.10
However, this decrease was associated with a marked reduction in Bcl-2 rather than with an increase in Bax itself [24].
Positive_regulation (increase) of Bax
10) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.57 Pain Relevance 0.08
It clearly finds an association with an increase in Bax with a decrease in Bcl-xL expression and negates any involvement of Bak and Bcl-2 regulations in the damage induced by retinal ischemia 24 h after reperfusion.
Positive_regulation (increase) of Bax associated with ischemia and retina disease
11) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.71 Pain Relevance 0.17
Other examples include the apoptosis-inducing protein Bax, which is activated by oligomerization via disulfide bridges formed by ROS in colorectal cancer cells [27], and H2O2-mediated inactivation of receptor protein–tyrosine phosphatases by formation of disulfide-bridged dimers [28].
Positive_regulation (activated) of Bax in bridges associated with colon cancer and apoptosis
12) Confidence 0.45 Published 2010 Journal Biol Trace Elem Res Section Body Doc Link PMC2855032 Disease Relevance 0.43 Pain Relevance 0.03
For example, the addition of this compound to cultured pneumocytes was found to reduce the LPS-induced generation of ROS and the activation of mitogen-activated protein kinases and Bax [29]; and the pretreatment of rats with 5% TAU in the drinking water resulted in a lower number of inflammatory leukocytes infiltrating the lung and in attenuation of the focal bronchiolar hyperplasia that developed from a short contact with ozone [30].
Positive_regulation (activation) of Bax in leukocytes associated with inflammation and hyperplasia
13) Confidence 0.45 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994390 Disease Relevance 0.87 Pain Relevance 0.12
Group 1 had increased ratios of bcl-2/beta-actin, bax/beta-actin, and bax/bcl-2 mRNA at 1 h after CPB (bcl-2/beta-actin, 0.82 +/- 0.14 versus 0.63 +/- 0.07; P = 0.03; bax/beta-actin, 1.04 +/- 0.14 versus 0.56 +/- 0.03; P = 0.00; bax/bcl-2, 1.31 +/- 0.12 versus 0.84 +/- 0.09; P = 0.02; Group 1 versus Group 2, respectively).
Positive_regulation (increased) of bax
14) Confidence 0.45 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.36 Pain Relevance 0.24
Group 1 had increased ratios of bcl-2/beta-actin, bax/beta-actin, and bax/bcl-2 mRNA at 1 h after CPB (bcl-2/beta-actin, 0.82 +/- 0.14 versus 0.63 +/- 0.07; P = 0.03; bax/beta-actin, 1.04 +/- 0.14 versus 0.56 +/- 0.03; P = 0.00; bax/bcl-2, 1.31 +/- 0.12 versus 0.84 +/- 0.09; P = 0.02; Group 1 versus Group 2, respectively).
Positive_regulation (increased) of bax
15) Confidence 0.45 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.36 Pain Relevance 0.24
Maternal oral consumption of morphine increases Bax/Bcl-2 ratio and caspase 3 activity during early neural system development in rat embryos.
Positive_regulation (increases) of Bax in embryos associated with morphine
16) Confidence 0.44 Published 2010 Journal J. Mol. Neurosci. Section Title Doc Link 19936637 Disease Relevance 0.17 Pain Relevance 0.51
Therefore, it would be interesting to study Bnip3-induced activation of Bax and Bak and to analyze whether Bnip-3 could also be associated with the increase in apoptosis observed after I/R in the retina.
Positive_regulation (activation) of Bax in retina associated with apoptosis
17) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.77 Pain Relevance 0.07
There was an increase in caspase-3 and Bax mRNA levels at 4W.
Positive_regulation (increase) of Bax
18) Confidence 0.40 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC119850 Disease Relevance 0.18 Pain Relevance 0.03
Prior treatment of natansnin (both concentrations) reduced the incidence of apoptosis by decreasing the activation of Bax and Bid.
Positive_regulation (activation) of Bax associated with apoptosis
19) Confidence 0.39 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 0.98 Pain Relevance 0.10
Increased activation of Bax and Bid in CCl4 treated rats indicates apoptosis is more in these rats.
Positive_regulation (activation) of Bax associated with apoptosis
20) Confidence 0.39 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 0.87 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox