INT102108

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Context Info
Confidence 0.64
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.69
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
neurons 1
muscles 1
upper 1
Bax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 8 98.72 Very High Very High Very High
cytokine 15 84.56 Quite High
Inflammation 57 84.16 Quite High
Central nervous system 10 69.68 Quite High
antagonist 5 68.88 Quite High
Inflammatory response 2 68.28 Quite High
nMDA receptor 4 61.92 Quite High
anesthesia 2 60.36 Quite High
Bile 1 21.76 Low Low
Mechanotransduction 1 20.84 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 101 100.00 Very High Very High Very High
Insulin Resistance 10 99.12 Very High Very High Very High
Cancer 121 98.80 Very High Very High Very High
Cv Unclassified Under Development 7 98.72 Very High Very High Very High
Hepatocellular Cancer 9 97.00 Very High Very High Very High
Death 17 89.12 High High
INFLAMMATION 65 84.16 Quite High
Necrosis 6 82.64 Quite High
Stress 21 78.20 Quite High
Fistula 21 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ischemia/reperfusion increases the overall expression of both bcl-2 and bax proteins, but bcl-2 is lost from the reperfused area as indicated by TUNEL staining.
Protein_catabolism (proteins) of bax associated with ischemia
1) Confidence 0.64 Published 2001 Journal Jpn Heart J Section Abstract Doc Link 11933925 Disease Relevance 0.55 Pain Relevance 0.15
Caspase-8, combined with its ability to induce apoptosis through the extrinsic pathway, also triggers the intrinsic apoptosis pathway by cleaving the pro-apoptotic Bcl-2 family members Bax and Bid to initiate mitochondrial-induced apoptosis [36-38].
Protein_catabolism (cleaving) of Bax associated with apoptosis
2) Confidence 0.64 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 1.14 Pain Relevance 0.07
Andrographolide induces apoptosis in human cancer cells via the activation of caspase 8, pro-apoptotic Bcl-2 family members Bax conformational change, release of cytochrome C from mitochondria and activation of caspase cascade [52] and/or via the activation of tumour suppressor p53 by ROS-dependent c-Jun NH2-terminal kinase (JNK) activation, thereby increasing p53 phosphorylation and protein stabilization [53,54].
Protein_catabolism (family) of Bax associated with cancer and apoptosis
3) Confidence 0.64 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 1.13 Pain Relevance 0
Mohd Yusof et al. determine the antiproliferative and apoptosis effects of hot water extract of Chlorella vulgaris on the hepatoma cell line, HepG2 and conclude that it may have anticancer effects possibly by inducing apoptosis signaling cascades via increased expression of P53, Bax and caspase?
Protein_catabolism (caspase) of Bax associated with hepatocellular cancer and apoptosis
4) Confidence 0.64 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020329 Disease Relevance 0.77 Pain Relevance 0.07
In granule neurons, the protein Bax has been described to be phosphorylated by GSK3, and this could be one possible target for P2X7 receptors [15].
Protein_catabolism (protein) of Bax in neurons
5) Confidence 0.20 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.19 Pain Relevance 0.03
The upper regulation of Fas and Bax protein was an association phenomenon.
Protein_catabolism (protein) of Bax in upper
6) Confidence 0.17 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.72 Pain Relevance 0.03
Expression of apoptosis-related molecules, such as Bcl-xS, Bax, and caspase-3, seems to be little regulated in the early stage of this vessel remodeling process.


Protein_catabolism (as) of Bax associated with apoptosis
7) Confidence 0.17 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC119850 Disease Relevance 0.67 Pain Relevance 0
In studies of muscles from insulin-deficient rats or db/db mice (a model of insulin resistance), we found that accelerated muscle protein degradation increases the level of the proapoptotic factor, Bax [35, 41].
Protein_catabolism (degradation) of Bax in muscles associated with insulin resistance
8) Confidence 0.13 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.53 Pain Relevance 0.12

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