INT102110

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 42
Total Number 42
Disease Relevance 35.77
Pain Relevance 9.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
cerebral cortex 3
embryos 2
retina 2
bladder 2
apoptotic cells 2
Bax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 43 99.98 Very High Very High Very High
ischemia 271 99.74 Very High Very High Very High
Sciatic nerve 8 99.68 Very High Very High Very High
Ultiva 9 99.66 Very High Very High Very High
Spinal cord 6 99.40 Very High Very High Very High
Clonidine 9 99.38 Very High Very High Very High
cerebral cortex 12 99.28 Very High Very High Very High
unmyelinated 1 98.80 Very High Very High Very High
Neurobehavioral 7 94.00 High High
Calcitonin gene-related peptide 1 92.52 High High
Disease Link Frequency Relevance Heat
Apoptosis 900 100.00 Very High Very High Very High
Hypoxia 158 100.00 Very High Very High Very High
Cancer 18 100.00 Very High Very High Very High
Myocardial Infarction 348 99.92 Very High Very High Very High
Cv Unclassified Under Development 179 99.74 Very High Very High Very High
Injury 153 99.70 Very High Very High Very High
Death 169 98.64 Very High Very High Very High
Diabetes Mellitus 294 98.56 Very High Very High Very High
Shock 8 98.40 Very High Very High Very High
B-cell Acute Lymphoblastic Leukemia 2 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High glucose also causes a 2 fold increase in Bax expression, which induced cytochrome C release which in turn stimulates apoptosis activating factor, caspase 9 and caspase 3 [41].
Positive_regulation (increase) of Gene_expression (expression) of Bax associated with apoptosis
1) Confidence 0.67 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570581 Disease Relevance 1.10 Pain Relevance 0.04
Mohd Yusof et al. determine the antiproliferative and apoptosis effects of hot water extract of Chlorella vulgaris on the hepatoma cell line, HepG2 and conclude that it may have anticancer effects possibly by inducing apoptosis signaling cascades via increased expression of P53, Bax and caspase?
Positive_regulation (increased) of Gene_expression (expression) of Bax associated with hepatocellular cancer and apoptosis
2) Confidence 0.67 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020329 Disease Relevance 0.82 Pain Relevance 0.07
It also reversed the potassium cyanide-induced increased expression of Bax and decreased expression of Bcl-2 to control levels.
Positive_regulation (induced) of Gene_expression (expression) of Bax
3) Confidence 0.61 Published 2006 Journal Neuroscience Section Abstract Doc Link 16464535 Disease Relevance 0.80 Pain Relevance 0.05
It also reversed the potassium cyanide-induced increased expression of Bax and decreased expression of Bcl-2 to control levels.
Positive_regulation (increased) of Gene_expression (expression) of Bax
4) Confidence 0.61 Published 2006 Journal Neuroscience Section Abstract Doc Link 16464535 Disease Relevance 0.80 Pain Relevance 0.05
An alternative explanation could be that apoptosis is triggered not by an increase in Bax expression but by its translocation to the mitochondria, as has been demonstrated in a central retinal artery occlusion model of retinal ischemia [2].
Neg (not) Positive_regulation (increase) of Gene_expression (expression) of Bax in retinal artery associated with ischemia, apoptosis and retina disease
5) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.76 Pain Relevance 0.11
Bax expression significantly increased by about 30% both at the mRNA (1.325±0.044) and protein levels (1.383±0.135), while Bcl-xL decreased by about 20% at the mRNA (0.787±0.033) and protein levels (0.826±0.106).
Positive_regulation (increased) of Gene_expression (expression) of Bax
6) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.15 Pain Relevance 0
Cell death after exposure to different NO-donors such as SNP has been to date established through the expression of tumor suppressor gene p53 and pro-apoptotic genes such as bax, cyclin-dependent kinase inhibitor p21, the inhibited expression of anti-apoptotic protein bcl-2, the inhibited NF-?
Positive_regulation (established) of Gene_expression (expression) of bax associated with cancer, apoptosis and death
7) Confidence 0.49 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.61 Pain Relevance 0
Cell death after exposure to different NO-donors such as SNP has been to date established through the expression of tumor suppressor gene p53 and pro-apoptotic genes such as bax, cyclin-dependent kinase inhibitor p21, the inhibited expression of anti-apoptotic protein bcl-2, the inhibited NF-?
Positive_regulation (established) of Gene_expression (expression) of bax associated with cancer, apoptosis and death
8) Confidence 0.49 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.68 Pain Relevance 0
Ischemia/reperfusion increases the overall expression of both bcl-2 and bax proteins, but bcl-2 is lost from the reperfused area as indicated by TUNEL staining.
Positive_regulation (increases) of Gene_expression (expression) of bax associated with ischemia
9) Confidence 0.49 Published 2001 Journal Jpn Heart J Section Abstract Doc Link 11933925 Disease Relevance 0.61 Pain Relevance 0.15
Maternal oral consumption of morphine increases Bax/Bcl-2 ratio and caspase 3 activity during early neural system development in rat embryos.
Positive_regulation (increases) of Gene_expression (ratio) of Bax in embryos associated with morphine
10) Confidence 0.47 Published 2010 Journal J. Mol. Neurosci. Section Title Doc Link 19936637 Disease Relevance 0.17 Pain Relevance 0.52
Immunohistochemical assay was used to reveal the protein expression of Bax, Bcl2, and the activation of caspase 3.
Positive_regulation (activation) of Gene_expression (expression) of Bax
11) Confidence 0.47 Published 2010 Journal J. Mol. Neurosci. Section Abstract Doc Link 19936637 Disease Relevance 0.20 Pain Relevance 0.67
These findings suggest that morphine exposure during the first embryonic days may enhance the susceptibility of neuroblasts to apoptosis by upregulating the ratio of Bax to Bcl-2 protein expression and increasing downstream caspase-3 activity.
Positive_regulation (upregulating) of Gene_expression (expression) of Bax in neuroblasts associated with apoptosis and morphine
12) Confidence 0.47 Published 2010 Journal J. Mol. Neurosci. Section Abstract Doc Link 19936637 Disease Relevance 0.15 Pain Relevance 0.69
Subchronic exposure to HD resulted in significantly increased expression of both anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bax and Caspase-3 in cerebral cortex and cerebellum, which exhibited a dose-dependent pattern.
Positive_regulation (increased) of Gene_expression (expression) of Bax in cerebral cortex associated with apoptosis and cerebral cortex
13) Confidence 0.46 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17492505 Disease Relevance 0.50 Pain Relevance 0.46
Though little change was detected in spinal cord, our results showed that the expression of Bcl-2, Bax and Caspase-3 was markedly enhanced in the sciatic nerves.
Positive_regulation (enhanced) of Gene_expression (expression) of Bax in sciatic nerves associated with sciatic nerve and spinal cord
14) Confidence 0.46 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17492505 Disease Relevance 0.50 Pain Relevance 0.46
The increase in caspase-3 and Bax protein expression confirm these results.
Positive_regulation (increase) of Gene_expression (expression) of Bax
15) Confidence 0.46 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.27 Pain Relevance 0.04
Increased Bax protein expression was noted in both sham- and MI-operated GK rats, in Wistar however, MI induced an increase in Bax protein expression (Figure 3D).
Positive_regulation (Increased) of Gene_expression (expression) of Bax associated with myocardial infarction
16) Confidence 0.46 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.29 Pain Relevance 0.04
Increased Bax protein expression was noted in both sham- and MI-operated GK rats, in Wistar however, MI induced an increase in Bax protein expression (Figure 3D).
Positive_regulation (increase) of Gene_expression (expression) of Bax associated with myocardial infarction
17) Confidence 0.46 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.18 Pain Relevance 0.03
In addition, western blot analysis also showed decreased Bcl-2 expression and increased Bax and caspase-3 expression.
Positive_regulation (increased) of Gene_expression (expression) of Bax
18) Confidence 0.44 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967004 Disease Relevance 0.87 Pain Relevance 0
Remifentanil preconditioning increased expression of ERK1/2 and anti-apoptotic protein Bcl-2 and decreased expression of pro-apoptotic proteins, Bax and cytochrome c, compared to ischemia-reperfusion only in wild-type rats.
Positive_regulation (increased) of Gene_expression (expression) of Bax associated with ischemia, ultiva and apoptosis
19) Confidence 0.42 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19944681 Disease Relevance 2.05 Pain Relevance 1.19
Ischemia and reperfusion induced myocardial injury significantly increased the expression of Bax protein (p < 0.001) compared with non-ischemic tissue from 3.50 ± 0.40 to 9.80 ± 0.50% (Fig 1).
Positive_regulation (increased) of Gene_expression (expression) of Bax protein associated with ischemia and injury
20) Confidence 0.41 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1397864 Disease Relevance 0.52 Pain Relevance 0.09

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