INT102112

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2011
Negated 23
Speculated 7
Reported most in Body
Documents 440
Total Number 447
Disease Relevance 209.32
Pain Relevance 22.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
brain 36
neurons 16
neuronal 9
Notch 7
skin 6
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 46 100.00 Very High Very High Very High
cerebral cortex 73 99.68 Very High Very High Very High
Thalamus 1187 99.60 Very High Very High Very High
ischemia 418 99.48 Very High Very High Very High
Hippocampus 796 99.40 Very High Very High Very High
anesthesia 1312 99.28 Very High Very High Very High
Central nervous system 269 99.24 Very High Very High Very High
Glutamate 268 98.48 Very High Very High Very High
Neuronal excitability 135 98.32 Very High Very High Very High
Spinal cord 221 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Creutzfeldt Jakob Disease 7485 100.00 Very High Very High Very High
Disease 6352 100.00 Very High Very High Very High
Targeted Disruption 3402 100.00 Very High Very High Very High
Infection 3367 100.00 Very High Very High Very High
Prion Diseases 2462 100.00 Very High Very High Very High
Alzheimer's Dementia 2241 100.00 Very High Very High Very High
Encephalopathy 1291 100.00 Very High Very High Very High
Scrapie 4891 99.96 Very High Very High Very High
Toxicity 491 99.92 Very High Very High Very High
Neuroblastoma 173 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our QRT-PCR analysis of Prnp gene expression after 1-h transient focal cerebral ischemia and 24-h reperfusion indicated distinct local differences in Prnp+/+ mouse brains.
Gene_expression (expression) of Prnp in brains associated with brain hemorrhage and ischemia
1) Confidence 0.78 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.19 Pain Relevance 0.10
RT-PCR analysis revealed a significantly increased expression of Prnp in the infarct-free region of the ipsilateral hemisphere after ischemia (P < 0.05).
Gene_expression (expression) of Prnp associated with ischemia
2) Confidence 0.78 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.51 Pain Relevance 0.22
We found a decrease in Prnp expression in the lesion area while the infarct-free region around the lesion of the ipsilateral hemisphere showed a significant increase.
Gene_expression (expression) of Prnp
3) Confidence 0.78 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.23 Pain Relevance 0.09
The up-regulation of PrPC mRNA levels in the area adjacent to the infarct may be triggered by local oxidative damage and other metabolic derangements in this area; this would be in keeping with in vitro analyses showing a correlation between PrP expression and oxidative stress (3).
Gene_expression (expression) of PrP associated with stress
4) Confidence 0.78 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.49 Pain Relevance 0.07
Mice lacking or overexpressing PrP(c) and their respective controls showed similar ventilatory patterns at rest and similar chemosensory responses when awake and under urethane anesthesia.
Neg (lacking) Gene_expression (overexpressing) of PrP associated with anesthesia
5) Confidence 0.78 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11950500 Disease Relevance 0.29 Pain Relevance 0.09
We found that the inhibitors caused accumulation of an unglycosylated, aggregated form of PrP exclusively in transfected N2a expressing PrP from the cytomegalovirus promoter.
Gene_expression (expressing) of PrP associated with cytomegalovirus infection
6) Confidence 0.78 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15632159 Disease Relevance 0.44 Pain Relevance 0.07
These mice, called Tg9949, express MoPrP(89-231) at levels 16 times higher than the normal PrPC expressed in wild-type mice [11].
Gene_expression (expressed) of PrPC
7) Confidence 0.78 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2950034 Disease Relevance 0.50 Pain Relevance 0
Legname et al. [6] produced truncated recombinant mouse PrP (MoPrP), corresponding to PrP27-30, and then converted this into amyloid fibrils.
Gene_expression (produced) of PrP associated with alzheimer's dementia
8) Confidence 0.78 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2950034 Disease Relevance 0.51 Pain Relevance 0
Transgenic mice carrying mutations and over-expressing PrP mutants spontaneously develop neurological symptoms similar to those of prion disorders, but their brain homogenates are infectious only for mice carrying the same mutation, and not for wild-type mice [5,26,27].
Gene_expression (expressing) of PrP in brain associated with targeted disruption
9) Confidence 0.78 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2950034 Disease Relevance 0.70 Pain Relevance 0
Here we explore the role of PrPc expression in neurotransmission and neural excitability using wild-type, Prnp ?
Gene_expression (expression) of PrPc in neural
10) Confidence 0.78 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2763346 Disease Relevance 0.31 Pain Relevance 0.15
Another group created transgenic mice stably expressing PrP shRNA that reduced PrPC expression five-fold, although they did not assess prion disease in these animals [25].
Gene_expression (expression) of PrPC associated with targeted disruption and prion diseases
11) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.67 Pain Relevance 0
PrPC expression was reported relative to that for untreated N2a cells.


Gene_expression (expression) of PrPC
12) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0 Pain Relevance 0
Briefly, we enriched for N2a cells lacking endogenous PrPC expression (N?
Neg (lacking) Gene_expression (expression) of PrPC
13) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.58 Pain Relevance 0
In this study, we have begun to explore the possibility of using LSPCs injected iv to deliver PrPC siRNA across the BBB to all areas of the brain to suppress PrPC expression on neurons to protect them from prion diseases.
Gene_expression (expression) of PrPC in neurons associated with prion diseases
14) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.59 Pain Relevance 0
Liposomes alone (figures 6a–e) or the RVM-9r peptide (figures 6f–j)delivered little or no siRNA, while the RVG-9r peptide delivered easily detectable amounts of siRNA to areas that appear to overlap with PrPC expression (figures 6k–t).
Gene_expression (expression) of PrPC
15) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.06 Pain Relevance 0
NCerP cells are a derivation of N2a cells that express cervid PrPC instead of mouse PrPC (our unpublished data).
Gene_expression (express) of PrPC
16) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.60 Pain Relevance 0
Following iv injection of fluorescent RVG-9r LSPCs into FVB mice, we found many labeled cells throughout the brain that also expressed PrPC, indicating that PrP siRNA can be delivered across the BBB to PrPC-expressing neuronal cells by a AchR-binding peptide.
Gene_expression (expressed) of PrPC in neuronal
17) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.41 Pain Relevance 0
This method also lacks desired temporal control of PrPC expression, since once brain cells are infected with lentivirus, it will likely irreversibly suppress PrPC expression in these cells.
Gene_expression (expression) of PrPC in brain
18) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.57 Pain Relevance 0
Importantly, though, RNAi treatment in all of these model systems dramatically impeded PrPRES replication by reducing PrPC expression by more than 50%, an expression threshold shown to dramatically delay disease onset [11], [12], [13], [14].
Gene_expression (expression) of PrPC associated with disease
19) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.82 Pain Relevance 0
Cells were either harvested and analyzed for peptide binding, siRNA delivery and/or PrPC expression; or supplemented with an additional 1 mL of cell culture media with antibiotics and incubated an additional 16–44 h before analyses.
Gene_expression (expression) of PrPC
20) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.27 Pain Relevance 0

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