INT102122

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Context Info
Confidence 0.29
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 5.83
Pain Relevance 4.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
sciatic nerve 2
soma 2
dorsal horn 2
IB4 1
DRG 1
Calca (Rattus norvegicus)
RT1-M4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 26 100.00 Very High Very High Very High
Dorsal horn 6 98.92 Very High Very High Very High
Spinal cord 10 98.60 Very High Very High Very High
Nerve growth factor 12 97.36 Very High Very High Very High
Sciatic nerve 6 97.24 Very High Very High Very High
substance P 6 96.72 Very High Very High Very High
dorsal root ganglion 29 96.30 Very High Very High Very High
allodynia 4 94.24 High High
peripheral neuropathy 2 93.48 High High
primary afferent fibers 2 83.44 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 2 98.64 Very High Very High Very High
Nervous System Injury 10 97.38 Very High Very High Very High
Ganglion Cysts 32 96.30 Very High Very High Very High
Nociception 15 96.22 Very High Very High Very High
Neuropathic Pain 6 94.24 High High
Peripheral Neuropathy 2 93.48 High High
Injury 4 92.28 High High
Shock 4 91.48 High High
Pain 5 77.40 Quite High
Increased Venous Pressure Under Development 8 72.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemical detection of calcitonin gene-related peptide (CGRP) and isolectin B4 (IB4) binding was used to visualize the dorsal horn distribution of the boutons from the peptidergic and non-peptidergic fibers respectively.
CGRP Binding (binding) of IB4 in dorsal horn associated with dorsal horn and calcitonin gene-related peptide
1) Confidence 0.29 Published 2006 Journal Neuroscience Section Abstract Doc Link 16413131 Disease Relevance 0.90 Pain Relevance 0.80
Immunocytochemical detection of calcitonin gene-related peptide (CGRP) and isolectin B4 (IB4) binding was used to visualize the dorsal horn distribution of the boutons from the peptidergic and non-peptidergic fibers respectively.
calcitonin gene-related peptide Binding (binding) of IB4 in dorsal horn associated with dorsal horn and calcitonin gene-related peptide
2) Confidence 0.22 Published 2006 Journal Neuroscience Section Abstract Doc Link 16413131 Disease Relevance 0.91 Pain Relevance 0.80
Here we provide the first direct comparison of rat pulmonary spinal and vagal pulmonary afferent neurons with respect to structural (soma size) and two neurochemical characteristics (binding of lectin IB4, immunoreactivity to calcitonin gene-related peptide=CGRP).
CGRP Binding (binding) of IB4 in soma associated with calcitonin gene-related peptide
3) Confidence 0.06 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16309834 Disease Relevance 0.71 Pain Relevance 0.48
Here we provide the first direct comparison of rat pulmonary spinal and vagal pulmonary afferent neurons with respect to structural (soma size) and two neurochemical characteristics (binding of lectin IB4, immunoreactivity to calcitonin gene-related peptide=CGRP).
calcitonin Binding (binding) of IB4 in soma associated with calcitonin gene-related peptide
4) Confidence 0.04 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16309834 Disease Relevance 0.70 Pain Relevance 0.48
A proportion of the CB1 receptor-like immunopositive neurones was immunostained for CGRP (31.7+/-5%) and IB4 (48.2%+/-7.5), with a minimal (1%) co-expression of CGRP and IB4 binding.
CGRP Binding (binding) of IB4 in IB4 associated with calcitonin gene-related peptide
5) Confidence 0.01 Published 2002 Journal Neuroscience Section Abstract Doc Link 11934481 Disease Relevance 0.36 Pain Relevance 0.48
Following sciatic nerve injury in adult rats and treatment with BRX-220, the following features of the sensory system were studied: (a) expression of calcitonin gene-related peptide (CGRP); (b) binding of isolectin B4 (IB4) in dorsal root ganglia (DRG) and spinal cord; (c) stimulation-evoked release of substance P (SP) in an in vitro spinal cord preparation and (d) nociceptive responses of partially denervated rats.
CGRP Binding (binding) of IB4 in sciatic nerve associated with nociception, nervous system injury, sciatic nerve, substance p, spinal cord and calcitonin gene-related peptide
6) Confidence 0.01 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14769355 Disease Relevance 0.62 Pain Relevance 0.49
Following sciatic nerve injury in adult rats and treatment with BRX-220, the following features of the sensory system were studied: (a) expression of calcitonin gene-related peptide (CGRP); (b) binding of isolectin B4 (IB4) in dorsal root ganglia (DRG) and spinal cord; (c) stimulation-evoked release of substance P (SP) in an in vitro spinal cord preparation and (d) nociceptive responses of partially denervated rats.
gene-related peptide Binding (binding) of IB4 in sciatic nerve associated with nociception, nervous system injury, sciatic nerve, substance p, spinal cord and calcitonin gene-related peptide
7) Confidence 0.01 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14769355 Disease Relevance 0.62 Pain Relevance 0.49
Small nociceptive DRG neurons are classified into nerve growth factor (NGF)-dependent neurons and glial cell line-derived neurotrophic factor (GDNF)-dependent neurons and they can be distinguished by their reactivity for CGRP and IB4, respectively.
CGRP Binding (reactivity) of IB4 in DRG associated with nociception, dorsal root ganglion, nerve growth factor and calcitonin gene-related peptide
8) Confidence 0.01 Published 2004 Journal Life Sci. Section Abstract Doc Link 15041445 Disease Relevance 1.02 Pain Relevance 0.92

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