INT102130

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Context Info
Confidence 0.05
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 7.39
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6, Crp) extracellular region (Il6)
Anatomy Link Frequency
hepatocytes 6
liver 2
adipose tissue 2
Il6 (Mus musculus)
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 81 99.92 Very High Very High Very High
cytokine 57 99.82 Very High Very High Very High
rheumatoid arthritis 135 96.48 Very High Very High Very High
Arthritis 43 87.88 High High
spinal inflammation 1 86.88 High High
palliative 1 56.88 Quite High
metalloproteinase 5 55.44 Quite High
Inflammatory mediators 7 6.04 Low Low
Pain 18 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 11 100.00 Very High Very High Very High
Necrosis 5 100.00 Very High Very High Very High
INFLAMMATION 79 99.92 Very High Very High Very High
Disease 148 99.28 Very High Very High Very High
Obesity 72 99.12 Very High Very High Very High
Hypercalcemia 8 98.80 Very High Very High Very High
Rheumatoid Arthritis 137 96.48 Very High Very High Very High
Increased Venous Pressure Under Development 2 93.12 High High
Hematological Disease 3 92.68 High High
Myocardial Infarction 3 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interleukin-6 (IL-6), IL-1, and tumor necrosis factor alpha induce the synthesis of CRP in hepatocytes.
Interleukin-6 Positive_regulation (induce) of Gene_expression (synthesis) of CRP in hepatocytes associated with necrosis and cancer
1) Confidence 0.05 Published 2002 Journal Curr Oncol Rep Section Abstract Doc Link 11937016 Disease Relevance 1.57 Pain Relevance 0.11
IL-6 stimulates hepatocytes and induces the production of several acute-phase proteins, such as C-reactive protein (CRP)33).
IL-6 Positive_regulation (induces) of Gene_expression (production) of CRP in hepatocytes
2) Confidence 0.04 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012271 Disease Relevance 0.89 Pain Relevance 0.38
C-reactive protein (CRP) production in the liver is upregulated by IL-1, IL-6 and TNF-?
IL-6 Positive_regulation (upregulated) of Gene_expression (production) of CRP in liver
3) Confidence 0.04 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 2.95 Pain Relevance 0.95
IL-6 stimulates hepatocytes and induces the production of several acute-phase proteins, such as C-reactive protein (CRP)33).
IL-6 Positive_regulation (induces) of Gene_expression (production) of C-reactive protein in hepatocytes
4) Confidence 0.03 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012271 Disease Relevance 0.89 Pain Relevance 0.38
In particular, obesity is strongly associated with CRP concentration (6, 10), because adipose tissue produces proinflammatory cytokines such as interleukin-6 (IL-6), which stimulates the production of CRP (11).
interleukin-6 Positive_regulation (stimulates) of Gene_expression (production) of CRP in adipose tissue associated with obesity and cytokine
5) Confidence 0.01 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721988 Disease Relevance 1.09 Pain Relevance 0.11

General Comments

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