INT10214

Context Info Confidence 0.78 First Reported 1989 Last Reported 2011 Negated 15 Speculated 4 Reported most in Body Documents 153 Total Number 157 Disease Relevance 115.88 Pain Relevance 16.29

cytosol (VIM) plasma membrane (VIM) cytoskeleton (VIM) cytoplasm (VIM)

Anatomy Link Frequency filament 11 smooth muscle 10 fibroblast 8 neuron 5 spindle cells 4 VIM (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 404 99.92 Inflammation 249 99.68 Infliximab 98 99.68 Enkephalin 6 99.44 Opioid 10 99.38 endometriosis 8 97.96 Snapping jaw 44 97.32 Inflammatory marker 2 96.12 interstitial cystitis 8 95.62 cytokine 121 95.60

Disease Link Frequency Relevance Heat Pancreatic Cancer 899 100.00 Lung Cancer 93 100.00 Colon Cancer 84 100.00 Ovarian Cancer 61 100.00 Lymphatic System Cancer 34 100.00 Cancer 2836 99.98 Paraganglioma 25 99.98 Rheumatoid Arthritis 408 99.92 Carcinoma 450 99.84 Clear Cell Sarcoma 61 99.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In particular, intensive vimentin expression was detected in the hypertrophic synovial membrane of internal derangement cases.

Gene_expression (expression) of vimentin in internal

1) Confidence 0.78 Published 2004 Journal J Oral Rehabil Section Abstract Doc Link 15125596 Disease Relevance 0.39 Pain Relevance 0.47

Vimentin expression was distributed in chondrocyte-like cells, synovial cells and endothelial cells.

Gene_expression (expression) of Vimentin in synovial cells

2) Confidence 0.78 Published 2004 Journal J Oral Rehabil Section Abstract Doc Link 15125596 Disease Relevance 0.44 Pain Relevance 0.49

Immunohistochemical study demonstrated a positive reaction in the epithelial component for keratin and epithelial membrane antigen, and not only these epithelial markers but also vimentin were expressed in some spindle tumor cells.

Gene_expression (expressed) of vimentin associated with cancer

3) Confidence 0.78 Published 1992 Journal Acta Pathol. Jpn. Section Abstract Doc Link 1471533 Disease Relevance 0.96 Pain Relevance 0.08

The observed decrease in CDH1 (E-cadherin) in CC (p-value = 0.0045) also matched previously published reports, as did the decrease in VIM (vimentin) expression in Chr RCCa [13,16].

Gene_expression (expression) of VIM associated with renal cancer and carcinoma

4) Confidence 0.75 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.28 Pain Relevance 0

The tumour also expressed vimentin.

Gene_expression (expressed) of vimentin associated with cancer

5) Confidence 0.75 Published 1993 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 8404499 Disease Relevance 1.03 Pain Relevance 0.16

In both samples tumor cells coexpressed cytokeratin and vimentin.

Gene_expression (coexpressed) of vimentin associated with cancer

6) Confidence 0.75 Published 1996 Journal Diagn. Cytopathol. Section Abstract Doc Link 8732655 Disease Relevance 1.07 Pain Relevance 0.09

Pancreatic tumor tissues showed greater than a 3-fold higher expression of total vimentin protein than did the lung, colon, and ovarian tumors that were analyzed.

Gene_expression (expression) of vimentin in colon associated with ovarian cancer and pancreatic cancer

7) Confidence 0.74 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2528299 Disease Relevance 0.89 Pain Relevance 0.16

Analysis of vimentin expression by 2-D PAGE

Gene_expression (expression) of vimentin

8) Confidence 0.74 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 0.65 Pain Relevance 0

Expression of vimentin has been postulated to play a role in invasiveness and metastasis in cervical carcinoma (17).

Gene_expression (Expression) of vimentin associated with reprotox - general 1 and metastasis

9) Confidence 0.74 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 1.01 Pain Relevance 0.07

Although vimentin expression is approximately three fold higher in pancreatic tumors at the protein level, as compared to other tumors analyzed in our study, only a single isoform of vimentin had demonstrable immunogenicity to autoantibodies in pancreatic cancer patient’s sera.

Gene_expression (expression) of vimentin associated with cancer and pancreatic cancer

10) Confidence 0.74 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 1.16 Pain Relevance 0.18

Using 2-D PAGE, we examined the expression of the different vimentin isoforms in a variety of tissues and tumor types.

Spec (examined) Gene_expression (expression) of vimentin associated with cancer

11) Confidence 0.74 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 0.93 Pain Relevance 0

However, Heatley et al. have shown that vimentin expression could not differentiate between benign and invasive breast lesions, although its expression was correlated with tumor grade and decreased survival in ductal carcinoma (18).

Gene_expression (expression) of vimentin associated with ductal carcinoma and cancer

12) Confidence 0.74 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 1.06 Pain Relevance 0.06

A similar pattern of expression was also observed in 6 pancreatic tumors, 38 lung tumors, 7 colon tumors and 25 ovarian tumors (Fig. 4), suggesting that the major vimentin isoforms were ubiquitously expressed.

Gene_expression (expressed) of vimentin in colon associated with lung cancer, ovarian cancer, colon cancer and pancreatic cancer

13) Confidence 0.74 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 1.72 Pain Relevance 0

Vimentin protein expression levels were investigated by comparing the integrated intensity of spots visualized in 2-D PAGE gels of various cancers.

Spec (investigated) Gene_expression (expression) of Vimentin associated with cancer

14) Confidence 0.74 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2528299 Disease Relevance 1.00 Pain Relevance 0.17

Thus, the immunoreactivity of vimentin is unlikely to be related to the total level of vimentin protein expression.

Gene_expression (expression) of vimentin

15) Confidence 0.74 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 1.33 Pain Relevance 0.21

We hypothesized that there might be changes in the expression level of the single minor antigenic isoform of vimentin that could lead to antigenicity in pancreatic cancer.

Gene_expression (expression) of vimentin associated with pancreatic cancer

16) Confidence 0.74 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 0.85 Pain Relevance 0

Immunoperoxidase stains showed characteristic expression of CD34 and vimentin.

Gene_expression (expression) of vimentin

17) Confidence 0.73 Published 1996 Journal Am. J. Ophthalmol. Section Body Doc Link 8604743 Disease Relevance 0.08 Pain Relevance 0

According to these findings it can be assumed that vimentin is expressed by all disc cell populations and it appears not to be influenced by any disease condition of the disc; on the other hand the up-regulation alpha-SM actin immunolabelling seems to be correlated to histopathological findings of tears and clefts.

Gene_expression (expressed) of vimentin in tears associated with disease

18) Confidence 0.72 Published 2002 Journal J Oral Rehabil Section Abstract Doc Link 11896846 Disease Relevance 0.56 Pain Relevance 0.47

The study, revealed that every disc cell constantly expressed vimentin.

Gene_expression (expressed) of vimentin

19) Confidence 0.72 Published 2002 Journal J Oral Rehabil Section Abstract Doc Link 11896846 Disease Relevance 0.58 Pain Relevance 0.52

The expression of vimentin and alpha-smooth muscle (alpha-SM) actin was examined in 10 human temporomandibular joint (TMJ) disc samples, with internal derangement and in two control specimens, in order to evaluate the phenotypic characteristics of TMJ disc cells in relationship to histological findings.

Gene_expression (expression) of vimentin in temporomandibular joint associated with snapping jaw

20) Confidence 0.72 Published 2002 Journal J Oral Rehabil Section Abstract Doc Link 11896846 Disease Relevance 0.47 Pain Relevance 0.47

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