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Context Info
Confidence 0.19
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.56
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Faslg) extracellular space (Faslg) extracellular region (Faslg)
cytoplasmic membrane-bounded vesicle (Faslg) plasma membrane (Faslg)
Anatomy Link Frequency
macrophages 1
endothelial cell 1
endothelium 1
Faslg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 20 99.74 Very High Very High Very High
cytokine 20 98.44 Very High Very High Very High
Inflammation 13 98.36 Very High Very High Very High
Morphine 16 97.96 Very High Very High Very High
Hippocampus 11 87.48 High High
antagonist 4 77.80 Quite High
opiate 2 77.00 Quite High
Etanercept 52 72.84 Quite High
Desipramine 1 57.64 Quite High
electroacupuncture 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 20 99.04 Very High Very High Very High
Apoptosis 112 98.44 Very High Very High Very High
INFLAMMATION 19 98.36 Very High Very High Very High
Diabetes Mellitus 142 96.56 Very High Very High Very High
Neurodegenerative Disease 35 92.40 High High
Affective Disorder 3 70.36 Quite High
Stress 11 66.16 Quite High
Death 58 65.48 Quite High
Injury 18 64.84 Quite High
Opiate Addiction 1 53.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and VEGF induce endothelial cell downregulation of FasL and upregulate Fas and adhesion molecules such as ICAM-1 [40].
Negative_regulation (downregulation) of FasL in endothelial cell associated with adhesions
1) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2716944 Disease Relevance 1.65 Pain Relevance 0.09
This downregulation of FasL in the endothelium, combined with the increased apoptotic threshold of leukocytes in diabetes [41], could result in a relative increase of surviving leukocytes in immunoprivileged areas such as the retina.
Negative_regulation (downregulation) of FasL in endothelium associated with diabetes mellitus and apoptosis
2) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2716944 Disease Relevance 1.63 Pain Relevance 0.08
Antidepressants are able to prevent Fas ligand (FasL)- or lipopolysaccharide (LPS)-induced apoptosis of NSCs through the upregulation of Bcl-2 and Bcl-XL expression [27–31].
Negative_regulation (prevent) of FasL associated with antidepressant and apoptosis
3) Confidence 0.17 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2885092 Disease Relevance 0.75 Pain Relevance 0.41
In comparison with model group 2, Bcl-2 IR-positive cell number of model group 1 decreased significantly (P < 0.05), Bax, Fas and FasL IR-positive cell number and Bax/Bcl-2 of model group 1 were significantly higher (P < 0.01, fl. 05).
Negative_regulation (decreased) of FasL
4) Confidence 0.13 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18928115 Disease Relevance 0.05 Pain Relevance 0
In addition, macrophages either deficient in FasL or lacking p53 showed resistance to the effect of morphine.
Negative_regulation (deficient) of FasL in macrophages associated with morphine
5) Confidence 0.10 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11937560 Disease Relevance 0.48 Pain Relevance 1.34

General Comments

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