INT102157

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 4.17
Pain Relevance 2.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adam17) cell motility (Adam17) cell adhesion (Adam17)
plasma membrane (Adam17) cytoplasm (Adam17)
Anatomy Link Frequency
sciatic nerve 2
dorsal 1
Adam17 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 19 100.00 Very High Very High Very High
Pain 14 99.80 Very High Very High Very High
antagonist 1 99.08 Very High Very High Very High
Eae 2 98.64 Very High Very High Very High
Spinal cord 3 97.56 Very High Very High Very High
Sciatic nerve 3 97.24 Very High Very High Very High
intrathecal 2 97.24 Very High Very High Very High
tolerance 7 93.48 High High
Peripheral nerve injury 2 88.64 High High
allodynia 4 82.52 Quite High
Disease Link Frequency Relevance Heat
Cancer 57 100.00 Very High Very High Very High
Necrosis 4 100.00 Very High Very High Very High
Non-diabetic Peripheral Neuropathy 6 99.80 Very High Very High Very High
Injury 4 97.80 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 97.32 Very High Very High Very High
Cirrhosis 2 95.16 Very High Very High Very High
Pain 8 91.88 High High
Wallerian Degeneration 4 89.88 High High
Nervous System Injury 2 88.64 High High
Neuropathic Pain 8 82.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used immunohistochemistry to analyze the distribution of TNF, TNF-releasing MMPs, including gelatinases (MMP-2 and MMP-9), and TNF-alpha converting enzyme (TACE) in painful neuropathy caused by chronic constriction injury of rat sciatic nerve.
Spec (analyze) Gene_expression (distribution) of TNF-alpha converting enzyme in sciatic nerve associated with pain, eae, injury, metalloproteinase and sciatic nerve
1) Confidence 0.58 Published 2002 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 11939349 Disease Relevance 0.86 Pain Relevance 0.67
We used immunohistochemistry to analyze the distribution of TNF, TNF-releasing MMPs, including gelatinases (MMP-2 and MMP-9), and TNF-alpha converting enzyme (TACE) in painful neuropathy caused by chronic constriction injury of rat sciatic nerve.
Spec (analyze) Gene_expression (distribution) of TACE in sciatic nerve associated with pain, eae, injury, metalloproteinase and sciatic nerve
2) Confidence 0.58 Published 2002 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 11939349 Disease Relevance 0.86 Pain Relevance 0.67
In Asia, where TACE has been a major nonsurgical option, radiotherapy has been introduced to improve the high rates of progression after TACE.
Gene_expression (progression) of TACE
3) Confidence 0.56 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768232 Disease Relevance 0.86 Pain Relevance 0.05
In a model of spinal immune activation by intrathecal HIV-1 gp120, we show that the anti-allodynic effects of minocycline are associated with decreased microglial activation, attenuated mRNA expression of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), IL-1beta-converting enzyme, TNF-alpha-converting enzyme, IL-1 receptor antagonist and IL-10 in lumbar dorsal spinal cord, and reduced IL-1beta and TNF-alpha levels in the CSF.
Gene_expression (expression) of TNF-alpha-converting in dorsal associated with necrosis, cancer, antagonist, acquired immune deficiency syndrome or hiv infection, spinal cord and intrathecal
4) Confidence 0.18 Published 2005 Journal Pain Section Abstract Doc Link 15836971 Disease Relevance 1.34 Pain Relevance 1.31
Introducing T345A into the conserved rat alpha2 enzyme does not alter cell growth or catalytic turnover but causes a substantial decrease in apparent K+ affinity (2-fold increase in K0.5(K+)).
Gene_expression (Introducing) of alpha2 enzyme
5) Confidence 0.03 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15308625 Disease Relevance 0.23 Pain Relevance 0.15

General Comments

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