INT102160

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Context Info
Confidence 0.28
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.87
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Mmp2, Mmp9) extracellular space (Mmp2, Mmp9) peptidase activity (Mmp2, Mmp9)
extracellular region (Mmp2, Mmp9) proteinaceous extracellular matrix (Mmp2, Mmp9) extracellular matrix organization (Mmp9)
Anatomy Link Frequency
immune cell 1
capillary 1
lung 1
Mmp2 (Rattus norvegicus)
Mmp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 268 100.00 Very High Very High Very High
fibrosis 84 97.48 Very High Very High Very High
ischemia 27 91.28 High High
Demyelination 1 89.60 High High
alcohol 2 88.84 High High
Sciatic nerve 1 86.48 High High
Eae 1 85.64 High High
Pain 3 83.68 Quite High
Inflammation 55 72.52 Quite High
Peripheral nerve injury 1 67.08 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Disease 5 99.04 Very High Very High Very High
Pulmonary Fibrosis 57 97.88 Very High Very High Very High
Neuropathic Pain 1 92.32 High High
Cv Unclassified Under Development 25 91.28 High High
Demyelinating Disease 1 89.60 High High
Disease 4 89.40 High High
Injury 27 87.88 High High
Reperfusion Injury 97 85.60 High High
Non-diabetic Peripheral Neuropathy 3 84.12 Quite High
Fibrosis 50 82.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Then, the sections were incubated with mouse monoclonal MMP-2 (CA-4001), or mouse monoclonal MMP-9 (IIA5) (Neomarkers, Fremont, CA, USA) (dilution 1 : 50) for 1 hour at room temperature (RT), and then, overnight at 4?.
MMP-2 Binding (incubated) of MMP-9 associated with metalloproteinase
1) Confidence 0.28 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.08 Pain Relevance 0.19
Studies showed that the activity of MMP-2 and MMP-9 is upregulated in many pulmonary diseases including pulmonary fibrosis,3-7 and they are secreted by many different kinds of cells in the lungs.8-11 But, the studies dealing with human lung can provide only a snap shot at a certain time point in its long course of disease.
MMP-2 Binding (activity) of MMP-9 in lung associated with fibrosis, pulmonary disease, metalloproteinase, pulmonary fibrosis and disease
2) Confidence 0.27 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.83 Pain Relevance 0.68
TNF co-localized in vessel endothelium with MMP-2 and in macrophages with MMP-9 and TACE at the period of active immune cell migration.
MMP-2 Binding (macrophages) of MMP-9 in immune cell associated with metalloproteinase
3) Confidence 0.15 Published 2002 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 11939349 Disease Relevance 0.87 Pain Relevance 0.77
Blood gas values, lung compliance, surfactant conversion, capillary permeability, and the presence of MMP-2 and MMP-9 in broncho-alveolar-lavage fluid (BALf) were determined.
MMP-2 Binding (presence) of MMP-9 in capillary
4) Confidence 0.03 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2335107 Disease Relevance 1.10 Pain Relevance 0.11

General Comments

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