INT102174

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Context Info
Confidence 0.65
First Reported 2002
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 6.40
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (FASN) small molecule metabolic process (FASN) lyase activity (FASN)
Golgi apparatus (FASN) cytoplasm (FASN) cytosol (FASN)
FASN (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 3 75.00 Quite High
abdominal pain 12 64.16 Quite High
Bioavailability 54 60.36 Quite High
tolerance 18 27.16 Quite Low
qutenza 3 8.56 Low Low
antagonist 222 5.00 Very Low Very Low Very Low
Inflammation 72 5.00 Very Low Very Low Very Low
local anesthetic 66 5.00 Very Low Very Low Very Low
agonist 54 5.00 Very Low Very Low Very Low
Angina 42 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 18 99.52 Very High Very High Very High
Malignant Neoplastic Disease 60 98.88 Very High Very High Very High
Skin Cancer 24 98.32 Very High Very High Very High
Fungal Infection 7 98.30 Very High Very High Very High
Sarcoma 6 97.92 Very High Very High Very High
Adenocarcinoma 21 97.48 Very High Very High Very High
Retinoblastoma 6 97.04 Very High Very High Very High
Wilms Tumor 6 96.40 Very High Very High Very High
Lung Cancer 48 95.76 Very High Very High Very High
Pancreatitis 12 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Currently, transcriptional profiles of T. rubrum response to three antifungal agents are integrated into TrED, including ketoconazole, amphotericin B and a novel synthetic fatty acid synthase inhibitor PHS11A [8,9].
Gene_expression (synthetic) of fatty acid synthase associated with fungal infection
1) Confidence 0.65 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1940010 Disease Relevance 0.18 Pain Relevance 0
The predominant product of FASN is the 16-carbon FA, palmitate.
Gene_expression (product) of FASN
2) Confidence 0.50 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.58 Pain Relevance 0.08
There are two sources of FAs for animal metabolism: Dietary FAs, and endogenously synthesized fatty acid synthase (FASN)-catalyzed FAs utilizing acetyl-CoA as primer, malonyl-CoA as two-carbon donor, and NADPH as reducing equivalent.
Gene_expression (sources) of fatty acid synthase
3) Confidence 0.50 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.63 Pain Relevance 0.09
Fas-L protein was expressed strongly in PDC, whereas only weak or no expression was noted in PT or PN.
Neg (no) Gene_expression (expressed) of Fas-L
4) Confidence 0.46 Published 2002 Journal Pathol. Int. Section Abstract Doc Link 11940212 Disease Relevance 0.53 Pain Relevance 0.07
This study investigated the mRNA and protein expression of CD97, CD95 and Fas-L in snap-frozen material obtained from human pancreatic ductal adenocarcinomas (PDC; n = 50), tissues from pancreatitis (PT; n = 40) and normal pancreatic tissues (PN; n = 36).
Gene_expression (expression) of Fas-L associated with adenocarcinoma and pancreatitis
5) Confidence 0.46 Published 2002 Journal Pathol. Int. Section Abstract Doc Link 11940212 Disease Relevance 0.61 Pain Relevance 0.07
Reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed that CD97, CD95 and Fas-L mRNA were expressed on a similarly high level in all tissues.
Gene_expression (expressed) of Fas-L mRNA
6) Confidence 0.46 Published 2002 Journal Pathol. Int. Section Abstract Doc Link 11940212 Disease Relevance 0.57 Pain Relevance 0.07
There are two sources of FAs for animal metabolism: Dietary FAs, and endogenously synthesized fatty acid synthase (FASN)-catalyzed FAs utilizing acetyl-CoA as primer, malonyl-CoA as two-carbon donor, and NADPH as reducing equivalent.
Gene_expression (synthesized) of FASN
7) Confidence 0.39 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.61 Pain Relevance 0.09
There are two sources of FAs for animal metabolism: Dietary FAs, and endogenously synthesized fatty acid synthase (FASN)-catalyzed FAs utilizing acetyl-CoA as primer, malonyl-CoA as two-carbon donor, and NADPH as reducing equivalent.
Gene_expression (synthesized) of fatty acid synthase
8) Confidence 0.39 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.61 Pain Relevance 0.09
There are two sources of FAs for animal metabolism: Dietary FAs, and endogenously synthesized fatty acid synthase (FASN)-catalyzed FAs utilizing acetyl-CoA as primer, malonyl-CoA as two-carbon donor, and NADPH as reducing equivalent.
Gene_expression (sources) of FASN
9) Confidence 0.39 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.63 Pain Relevance 0.09
FASN over-expression may actively contribute to malignant-phenotype development, maintenance, and/or promotion, because its inhibition by orlistat induces cell-cycle arrest and apoptosis in a wide variety of cancer cell lines including prostate, breast, gastrointestinal, chronic lymphocytic leukemia, and others [293-296], suggesting a role for FASN in the molecular integration of a number of signalling pathways that functionally link metabolism, proliferation, and survival in malignant cells.
Gene_expression (expression) of FASN associated with chronic lymphoid leukemia, malignant neoplastic disease, cancer and apoptosis
10) Confidence 0.38 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.38 Pain Relevance 0
Synthesis of esters derived from phytosterols or other steroid alcohols and FAs is of great importance, due to their recent recognition and application in the food industry as cholesterol-lowering agents.
Gene_expression (Synthesis) of FAs
11) Confidence 0.08 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635649 Disease Relevance 0 Pain Relevance 0
Structured lipids (SLs) are triacylglycerols or phospholipids in which FAs can be found in specific locations in the glycerol backbone and are produced using chemical or enzymatic processes.
Gene_expression (produced) of FAs
12) Confidence 0.06 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635649 Disease Relevance 0.07 Pain Relevance 0
Glycerides are important natural and sustainable sources of FAs.
Gene_expression (sources) of FAs
13) Confidence 0.06 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635649 Disease Relevance 0 Pain Relevance 0

General Comments

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