INT102175

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Context Info
Confidence 0.41
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (FASN) small molecule metabolic process (FASN) lyase activity (FASN)
Golgi apparatus (FASN) cytoplasm (FASN) cytosol (FASN)
FASN (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 1 75.00 Quite High
agonist 33 50.00 Quite Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 43 99.22 Very High Very High Very High
Adenocarcinoma 3 97.48 Very High Very High Very High
Pancreatitis 4 95.72 Very High Very High Very High
Apoptosis 9 95.44 Very High Very High Very High
Fatty Liver 3 92.04 High High
Diabetes Mellitus 22 68.80 Quite High
Body Weight 1 38.40 Quite Low
Toxicity 10 5.00 Very Low Very Low Very Low
Hepatotoxicity 9 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study investigated the mRNA and protein expression of CD97, CD95 and Fas-L in snap-frozen material obtained from human pancreatic ductal adenocarcinomas (PDC; n = 50), tissues from pancreatitis (PT; n = 40) and normal pancreatic tissues (PN; n = 36).
Transcription (expression) of Fas-L associated with adenocarcinoma and pancreatitis
1) Confidence 0.41 Published 2002 Journal Pathol. Int. Section Abstract Doc Link 11940212 Disease Relevance 0.61 Pain Relevance 0.07
Compared to wild type ob/ob mice, triglyceride content as well as mRNA levels of lipogenic genes, such as fatty acid synthase (Fasn), acetyl CoA carboxylase (Acc), and stearoyl CoA desaturase 1 (Scd1), were strongly decreased in corresponding PPAR?
Transcription (levels) of fatty acid synthase associated with obesity
2) Confidence 0.13 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.54 Pain Relevance 0

General Comments

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