INT102178

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.73
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 6.68
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD97) extracellular region (CD97) cell adhesion (CD97)
plasma membrane (CD97) cell-cell signaling (CD97) signal transducer activity (CD97)
Anatomy Link Frequency
leukocyte 3
thyroid 2
immune system 1
CD97 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 17 99.36 Very High Very High Very High
Neurotransmitter 3 81.36 Quite High
Chronic pancreatitis 3 75.00 Quite High
Glutamate 24 66.32 Quite High
Inflammation 5 65.16 Quite High
withdrawal 26 38.40 Quite Low
depression 4 19.44 Low Low
headache 4 18.48 Low Low
Pain 7 12.24 Low Low
Glutamate receptor 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 46 99.40 Very High Very High Very High
Low Back Pain 17 99.36 Very High Very High Very High
Discitis 2 97.88 Very High Very High Very High
Adhesions 36 96.84 Very High Very High Very High
Adenocarcinoma 9 96.84 Very High Very High Very High
Sacroiliitis 4 96.84 Very High Very High Very High
Apoptosis 5 95.44 Very High Very High Very High
Pancreatitis 12 95.08 Very High Very High Very High
Autoimmune Disease 2 92.48 High High
Cancer 32 90.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD97 protein expression was detected only in PT and in poorly differentiated PDC.
Gene_expression (expression) of CD97
1) Confidence 0.73 Published 2002 Journal Pathol. Int. Section Abstract Doc Link 11940212 Disease Relevance 0.51 Pain Relevance 0.07
This study investigated the mRNA and protein expression of CD97, CD95 and Fas-L in snap-frozen material obtained from human pancreatic ductal adenocarcinomas (PDC; n = 50), tissues from pancreatitis (PT; n = 40) and normal pancreatic tissues (PN; n = 36).
Gene_expression (expression) of CD97 associated with adenocarcinoma and pancreatitis
2) Confidence 0.73 Published 2002 Journal Pathol. Int. Section Abstract Doc Link 11940212 Disease Relevance 0.61 Pain Relevance 0.07
Reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed that CD97, CD95 and Fas-L mRNA were expressed on a similarly high level in all tissues.
Gene_expression (expressed) of CD97
3) Confidence 0.73 Published 2002 Journal Pathol. Int. Section Abstract Doc Link 11940212 Disease Relevance 0.57 Pain Relevance 0.07
Additionally, retinoids exert several re-differentiating effects: induction of 5'-DI [12,13] increased expression of NIS mRNA [14] and of the differentiation marker, alkaline phosphatase, or decreased expression of CD97, which is highly expressed in anaplastic thyroid carcinoma [15], as well as stimulation of intercellular adhesion molecule-1 synthesis [16].
Gene_expression (expression) of CD97 in thyroid associated with thyroid neoplasm and adhesions
4) Confidence 0.63 Published 2009 Journal Thyroid Res Section Body Doc Link PMC2739165 Disease Relevance 0.66 Pain Relevance 0
Additionally, retinoids exert several re-differentiating effects: induction of 5'-DI [12,13] increased expression of NIS mRNA [14] and of the differentiation marker, alkaline phosphatase, or decreased expression of CD97, which is highly expressed in anaplastic thyroid carcinoma [15], as well as stimulation of intercellular adhesion molecule-1 synthesis [16].
Gene_expression (expressed) of CD97 in thyroid associated with thyroid neoplasm and adhesions
5) Confidence 0.63 Published 2009 Journal Thyroid Res Section Body Doc Link PMC2739165 Disease Relevance 0.72 Pain Relevance 0
Group II in the human consists of CD97 and four EGF-like modules containing mucin-like receptor proteins (EMR1–4) [15].
Gene_expression (containing) of CD97
6) Confidence 0.25 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1472694 Disease Relevance 0.55 Pain Relevance 0.03
Since CD97 is present in the teleost Takifugu rubripes (unpublished data), this receptor appears to be have been lost in the lineage leading to the chicken, while the EMRs have probably expanded in mammals.
Gene_expression (present) of CD97
7) Confidence 0.23 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1472694 Disease Relevance 0.51 Pain Relevance 0.03
The pathology of AS is closely associated with the expression of the class I molecule human leukocyte antigen-B27.
Gene_expression (expression) of leukocyte antigen-B27 in leukocyte associated with spinal inflammation
8) Confidence 0.17 Published 2002 Journal Curr Rheumatol Rep Section Abstract Doc Link 12427366 Disease Relevance 1.20 Pain Relevance 0.68
The pathology of AS is closely associated with the expression of the class I molecule human leukocyte antigen-B27.
Gene_expression (expression) of leukocyte antigen-B27 in leukocyte associated with spinal inflammation
9) Confidence 0.15 Published 2002 Journal Curr Rheumatol Rep Section Abstract Doc Link 12427366 Disease Relevance 1.20 Pain Relevance 0.68
RESULTS: The 5 subsets of SpA share many clinical, immunohistochemical, and genetic features, including the common presence of human leukocyte antigen-B27 and the absence of rheumatoid factor.
Gene_expression (presence) of leukocyte antigen-B27 in leukocyte
10) Confidence 0.14 Published 2008 Journal Semin. Arthritis Rheum. Section Body Doc Link 18166219 Disease Relevance 0.09 Pain Relevance 0
EMR1 and CD97 are closely related in structure to two other human proteins (EMR2 and EMR3), and all members of this group are highly expressed in the immune system.
Gene_expression (expressed) of CD97 in immune system
11) Confidence 0.12 Published 2001 Journal Genome Biol Section Body Doc Link PMC138994 Disease Relevance 0.05 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox