INT102181

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.37
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CLTC) mitosis (CLTC) mitochondrion (CLTC)
vesicle-mediated transport (CLTC) structural molecule activity (CLTC) plasma membrane (CLTC)
CLTC (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 92.76 High High
imagery 4 86.20 High High
diclofenac 1 82.96 Quite High
Pain 9 5.00 Very Low Very Low Very Low
cva 7 5.00 Very Low Very Low Very Low
Gabapentin 5 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
intrathecal 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Penile Induration 11 92.64 High High
INFLAMMATION 1 92.20 High High
Keloid Scars 11 80.60 Quite High
Disease 127 79.60 Quite High
Fibrosis 9 78.96 Quite High
Infection 169 73.60 Quite High
Dengue 22 50.00 Quite Low
Dupuytren's Disease 7 50.00 Quite Low
Overdose 7 30.16 Quite Low
Toxicity 5 18.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Salicylic acid and ibuprofen noncompetitively inhibited the uptake of L-[(14)C]lactic acid. alpha-Cyano-4-hydroxycinnamate (CHC), a monocarboxylate transporter inhibitor, suppressed the uptake of L-[(14)C]lactic acid but not that of [(14)C]salicylic acid.
Negative_regulation (inhibitor) of CHC
1) Confidence 0.37 Published 2002 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 11940522 Disease Relevance 0.09 Pain Relevance 0.38
siRNA knockdown of clathrin heavy chain inhibits infectious entry of all four DENV serotypes
Negative_regulation (knockdown) of clathrin heavy chain
2) Confidence 0.35 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.41 Pain Relevance 0.04
In this study, clathrin-mediated endocytosis is identified as the main pathway of DENV internalisation, since knockdown of clathrin heavy chain and dynamin inhibits uptake by 70% or more (Figure 2 and Additional File 2).
Negative_regulation (knockdown) of clathrin heavy chain
3) Confidence 0.35 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0 Pain Relevance 0
First, they compared CHC activity (via measurement of desiccated tissue weight and release of free ?
Negative_regulation (compared) of CHC
4) Confidence 0.31 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 0.87 Pain Relevance 0
Uptake of GHB in MDA-MB231 cells was inhibited by the classic MCT inhibitors CHC, phloretin and pCMB with uptake being approximately 60% of control cells (10).
Negative_regulation (inhibitors) of CHC
5) Confidence 0.08 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0

General Comments

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