INT102187

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 26.54
Pain Relevance 4.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SH2B2) signal transduction (SH2B2) plasma membrane (SH2B2)
cytoplasm (SH2B2) signal transducer activity (SH2B2)
Anatomy Link Frequency
neurons 1
central nervous system 1
SH2B2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 27 100.00 Very High Very High Very High
Demyelination 27 99.80 Very High Very High Very High
anesthesia 13 99.76 Very High Very High Very High
Catechol-O-methyltransferase 763 99.68 Very High Very High Very High
corticosteroid 11 99.60 Very High Very High Very High
cva 407 99.04 Very High Very High Very High
Pain 151 99.04 Very High Very High Very High
aspirin 79 98.18 Very High Very High Very High
c fibre 5 97.92 Very High Very High Very High
Catecholamine 49 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anti-phospholipid Antibody Syndrome 1124 100.00 Very High Very High Very High
Hantavirus Infection 546 100.00 Very High Very High Very High
Syndrome 417 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 530 99.92 Very High Very High Very High
Demyelinating Disease 216 99.80 Very High Very High Very High
Thrombosis Related Under Development 482 99.58 Very High Very High Very High
Hepatolenticular Degeneration 9 99.32 Very High Very High Very High
Immunization 18 99.28 Very High Very High Very High
Disease 325 99.16 Very High Very High Very High
Pain 142 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No man using two or more BZDs or APs used per oral corticosteroids suggesting that the increase in fracture risk in these groups was not due to use of per oral corticosteroid.
Gene_expression (used) of APs associated with corticosteroid
1) Confidence 0.59 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2910682 Disease Relevance 0.40 Pain Relevance 0.18
The APs were detected by a matched filter constituting a maximum-likelihood constant false-alarm rate detector.
Gene_expression (detected) of APs associated with action potential
2) Confidence 0.53 Published 2002 Journal IEEE Trans Biomed Eng Section Abstract Doc Link 11942724 Disease Relevance 0 Pain Relevance 0.64
To test whether minor SNPs linked to APS or HPS haplotypes rescue COMT activity, further reduce it, or produce neutral effects, a series of molecular modeling and cell culture studies were performed.
Gene_expression (haplotypes) of APS associated with catechol-o-methyltransferase and hantavirus infection
3) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.41 Pain Relevance 0.24
Tight linkage of these neutral polymorphisms with more recently acquired low activity APS and HPS haplotypes does not satisfy a simple ancestral model and requires the development of a more complex population genetic model to account for pleiotropic selection.
Gene_expression (haplotypes) of APS associated with hantavirus infection
4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.57 Pain Relevance 0.37
Four individual minor SNPs were introduced in the parent APS (rs769224; 800G?
Gene_expression (introduced) of APS
5) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.45 Pain Relevance 0.17
Consistent with previous studies [37], protein expression levels exhibited by the APS haplotype did not differ relative to the LPS haplotype, while expression levels displayed by the HPS haplotype were reduced 4.5-fold (F6,7?
Gene_expression (haplotype) of APS associated with hantavirus infection
6) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.50 Pain Relevance 0.07
Previously constructed full-length cDNA COMT clones that differed only in three nucleotides corresponding to the LPS, APS, and HPS haplotypes were used [37].
Gene_expression (haplotypes) of APS associated with catechol-o-methyltransferase and hantavirus infection
7) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.46 Pain Relevance 0.20
While LPS, APS, and HPS haplotypes of the COMT gene are common in the population, accounting for nearly 96% of all detected haplotypes in the coding region [27], a significant number of less common minor SNPs are also situated in this region.
Gene_expression (haplotypes) of APS associated with catechol-o-methyltransferase and hantavirus infection
8) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.99 Pain Relevance 0.59
Also consistent with previous studies [37], enzymatic activity corresponding to both the APS and HPS haplotypes was reduced compared to the LPS haplotype (F6,7?
Gene_expression (haplotypes) of APS associated with hantavirus infection
9) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.62 Pain Relevance 0.03
In particular, it was observed that "triggering" factors become increasingly apparent in catastrophic APS, and these were present in 51% of cases in a recent analysis by Cervera et al. in 2003 [as cited in 14].
Gene_expression (apparent) of APS associated with anti-phospholipid antibody syndrome
10) Confidence 0.39 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.07 Pain Relevance 0.04
Neuropsychiatric syndromes in APS (predominant vascular-ischemic / occlusive origin)
Gene_expression (syndromes) of APS associated with syndrome and anti-phospholipid antibody syndrome
11) Confidence 0.39 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.47 Pain Relevance 0.03
Additionally, cerebral venous thrombosis is another uncommon appearance in APS but it may be involved in a range of hypercoagulable states,145 especially in young women.146

Transient global amnesia

Gene_expression (appearance) of APS associated with anti-phospholipid antibody syndrome, amnesia and thrombosis related under development
12) Confidence 0.39 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.91 Pain Relevance 0.17
A familial clustering is suggestive for a primary APS.135 Early inflammatory reactions (endothelitis) of the small arteries occur as followed by subendothelial cell proliferation leading to partial or complete occlusion.136 Therefore, there is accumulating evidence in support of the association (Sneddon's syndrome) not only in SLE and/or APS but in the general population as well.
Gene_expression (/) of APS associated with inflammation, syndrome, anti-phospholipid antibody syndrome and systemic lupus erythematosus
13) Confidence 0.39 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.41 Pain Relevance 0.10
Discussion of therapeutic approaches in APS is beyond the scope of this overview, but most recent advances, especially in CAPS which is the most life-threatening variant of APS, are listed briefly as follows:
Gene_expression (approaches) of APS associated with anti-phospholipid antibody syndrome
14) Confidence 0.39 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.97 Pain Relevance 0.12
Rapid chronological occlusive events, occurring over days to weeks, have been referred to as "catastrophic" APS (CAPS).22
Gene_expression (.22) of APS associated with anti-phospholipid antibody syndrome
15) Confidence 0.39 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.63 Pain Relevance 0.04
THERAPIES IN APS
Gene_expression (THERAPIES) of APS associated with anti-phospholipid antibody syndrome
16) Confidence 0.39 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.97 Pain Relevance 0.12
At the same time it was found that 75% of LA patients were positive for HCV, which further supports the possible association between chronic HCV infection and aPLs85 Recently, a case of Wilson's disease (hepatolenticular degeneration) was reported along with primary APS in a patient presenting mainly with extrapyramidal damage.86 The latter was supposed to have had an autoimmune aPL component provoking mainly recurrent arterial/venous thrombosis and thrombocytopenia, but a possible systemic cellular involvement by aPLs in the central nervous system (besides thrombosis) may have interacted with a specific genetic background.51

Digestive manifestations

Gene_expression (presenting) of APS in central nervous system associated with anti-phospholipid antibody syndrome, hepatolenticular degeneration, thrombosis related under development, disease, hepatitis c virus infection, infection, central nervous system and thrombocytopenia
17) Confidence 0.39 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.52 Pain Relevance 0.08
2GPI.117 Furthermore, immunization of BALB/c mice with monoclonal aCL resulted in APS with neurological dysfunction and impaired motor coordination.118,119
Gene_expression (resulted) of APS associated with anesthesia, anti-phospholipid antibody syndrome and immunization
18) Confidence 0.39 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.99 Pain Relevance 0.12
To determine whether outward K+ currents contributed to the APs, we analyzed outward currents in response to voltage steps from a holding potential of ?
Spec (whether) Gene_expression (contributed) of APs associated with action potential
19) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0.06 Pain Relevance 0.31
Despite progress in AT, there is still a large number of people with severe motor disabilities who cannot fully benefit from AT due to their limited access to current assistive products (APs).
Gene_expression (products) of APs
20) Confidence 0.08 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2944670 Disease Relevance 0 Pain Relevance 0

General Comments

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