INT102199

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.25
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 100.00 Very High Very High Very High
rheumatoid arthritis 6 99.92 Very High Very High Very High
cytokine 7 95.04 Very High Very High Very High
Neuropathic pain 1 93.80 High High
Pain 1 84.24 Quite High
Inflammation 3 79.16 Quite High
Inflammatory response 1 36.84 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 6 99.92 Very High Very High Very High
Wallerian Degeneration 15 99.44 Very High Very High Very High
Neuropathic Pain 1 93.80 High High
Necrosis 2 90.80 High High
Cancer 2 90.44 High High
Pain 1 84.24 Quite High
Synovitis 1 82.76 Quite High
Disease 1 79.48 Quite High
INFLAMMATION 4 79.16 Quite High
Injury 3 70.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to rapid-WD, the production of TNFalpha, IL-1alpha, and IL-1beta protein was deficient in slow-WD, although their mRNAs were expressed. mRNA expression and protein production of TNFalpha, IL-1alpha, and IL-1beta were differentially regulated during rapid-WD and slow-WD, suggesting that mRNA expression, by itself, is no indication of the functional involvement of cytokines in WD.
Regulation (regulated) of Transcription (expression) of TNFalpha associated with wallerian degeneration and cytokine
1) Confidence 0.45 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.32 Pain Relevance 0.26
Prescription of TNFalpha antagonists is controlled, according local restrictions, regarding high costs of the therapy.
Regulation (controlled) of Transcription (Prescription) of TNFalpha associated with antagonist
2) Confidence 0.44 Published 2008 Journal Reumatizam Section Abstract Doc Link 19024266 Disease Relevance 0.93 Pain Relevance 0.52

General Comments

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