INT102200

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Context Info
Confidence 0.72
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.69
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr4a2) DNA binding (Nr4a2) response to stress (Nr4a2)
cytoplasm (Nr4a2)
Anatomy Link Frequency
stem cells 2
juvenile 1
PNS 1
granulosa cells 1
eosinophil 1
Nr4a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 15 96.96 Very High Very High Very High
narcan 1 95.72 Very High Very High Very High
antagonist 1 95.36 Very High Very High Very High
opioid receptor 1 94.92 High High
fluoxetine 2 87.60 High High
cytokine 32 87.04 High High
Inflammation 23 86.64 High High
ischemia 1 84.24 Quite High
Hippocampus 2 78.96 Quite High
Inflammatory response 1 78.92 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 97 99.10 Very High Very High Very High
Aggression 6 99.10 Very High Very High Very High
Neurodegenerative Disease 12 98.00 Very High Very High Very High
Wallerian Degeneration 15 97.24 Very High Very High Very High
Cognitive Disorder 2 92.12 High High
Injury 6 90.28 High High
INFLAMMATION 23 86.64 High High
Cv Unclassified Under Development 1 84.24 Quite High
Cancer 6 75.00 Quite High
Necrosis 5 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that communication in juvenile is important in the survival and differentiation of newly divided cells, which may be associated with memory and aggression, and raise the possibility that the reduced expression of Nurr1 and/or Npas4 may contribute to the impairment of neurogenesis and memory and aggression induced by SI.
Gene_expression (expression) of Nurr1 in juvenile associated with aggression and neurodegenerative disease
1) Confidence 0.72 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18182044 Disease Relevance 0.65 Pain Relevance 0.08
We finally found that SI reduced the expression of development-related genes Nurr1 and Npas4.
Gene_expression (expression) of Nurr1
2) Confidence 0.72 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18182044 Disease Relevance 0.40 Pain Relevance 0.09
The results of Western blot analysis showed that only cPKCgamma membrane translocation, not alpha, betaI and betaII, increased under the condition of OGD 10 min and 2h reperfusion (OGD/2h), and this increment of cPKCgamma membrane translocation was inhibited by MP pretreatment.
Gene_expression (alpha) of not
3) Confidence 0.65 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18706478 Disease Relevance 0.08 Pain Relevance 0.43
LH was shown to induce Nr4a2 expression in mouse granulosa cells [37].
Gene_expression (expression) of Nr4a2 in granulosa cells
4) Confidence 0.61 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.13 Pain Relevance 0
TNFalpha and IL-1alpha mRNAs were expressed, whereas TNFalpha but not IL-1alpha protein was synthesized in intact PNS of C57/BL mice.
Neg (not) Gene_expression (synthesized) of not in PNS
5) Confidence 0.58 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.41 Pain Relevance 0.28
CD30 stimulation recently has been shown to cause eosinophil-specific apoptosis.142 It has been further reported that CD30 stimulation markedly induced Nur77 and NOR1, NR4A nuclear receptor family, during eosinophil-specific apoptosis.143 However, CD30 stimulation did not alter Nurr1 expression in this system.
Gene_expression (expression) of Nurr1 in eosinophil associated with apoptosis
6) Confidence 0.11 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.81 Pain Relevance 0.06
It has been reported that over-expression of Nurr-1 induced neurite elongation and led to differentiation of neural stem cells to dopaminergic neurons [43-45].
Gene_expression (over) of Nurr-1 in stem cells
7) Confidence 0.07 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.06 Pain Relevance 0.12
We assessed the expression of tyrosine hydroxylase (TH) and Nurr-1.
Gene_expression (expression) of Nurr-1
8) Confidence 0.06 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.07 Pain Relevance 0.10
It has been reported that over-expression of Nurr-1 induced neurite elongation and led to differentiation of neural stem cells to dopaminergic neurons [43-45].
Gene_expression (expression) of Nurr-1 in stem cells
9) Confidence 0.05 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.06 Pain Relevance 0.12

General Comments

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