INT102201

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Context Info
Confidence 0.39
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.57
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnf, Il1b) extracellular region (Tnf, Il1b) aging (Il1b)
intracellular (Tnf) extracellular matrix organization (Tnf) cell proliferation (Tnf)
Anatomy Link Frequency
PNS 1
Tnf (Mus musculus)
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 11 100.00 Very High Very High Very High
Inflammation 2 100.00 Very High Very High Very High
Neuropathic pain 2 98.56 Very High Very High Very High
Inflammatory response 1 93.52 High High
Dynorphin 1 89.44 High High
allodynia 1 88.00 High High
Pain 1 78.64 Quite High
Demyelination 1 64.08 Quite High
neuralgia 3 25.00 Low Low
cINOD 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Necrosis 4 100.00 Very High Very High Very High
Cancer 4 100.00 Very High Very High Very High
INFLAMMATION 4 100.00 Very High Very High Very High
Neuropathic Pain 3 99.00 Very High Very High Very High
Injury 4 98.92 Very High Very High Very High
Wallerian Degeneration 15 95.64 Very High Very High Very High
Neurodegenerative Disease 2 91.88 High High
Pain 1 78.64 Quite High
Nociception 2 75.00 Quite High
Targeted Disruption 2 71.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytokines such as IL-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha) have been shown to contribute directly to central and peripheral neuropathic pain.
TNF-alpha Regulation (contribute) of IL-1beta associated with necrosis, cancer, neuropathic pain and cytokine
1) Confidence 0.39 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12799032 Disease Relevance 0.67 Pain Relevance 0.36
We presently document the involvement of the inflammatory cytokines TNFalpha, interleukin (IL)-1alpha, and IL-1beta in peripheral nerve (PNS) injury in C57/BL/6NHSD (C57/BL) mice that display the normal rapid progression of WD (rapid-WD) and C57/BL/6-WLD/OLA/NHSD mice that display abnormal slow progression of WD (slow-WD).
TNFalpha Regulation (involvement) of IL-1beta in PNS associated with inflammation, injury, wallerian degeneration and cytokine
2) Confidence 0.30 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.39 Pain Relevance 0.28
The beneficial or detrimental roles of these cytokines, including interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha), remain to be clarified.
TNF-alpha Regulation (roles) of IL-1beta associated with necrosis, cancer and cytokine
3) Confidence 0.21 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16399681 Disease Relevance 0.51 Pain Relevance 0.18

General Comments

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