INT102202

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 4.55
Pain Relevance 4.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
amygdala 4
frontal cortex 4
neutrophil 2
striatum 1
hippocampus 1
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 19 100.00 Very High Very High Very High
amygdala 3 100.00 Very High Very High Very High
long-term potentiation 84 99.90 Very High Very High Very High
Serotonin 6 99.44 Very High Very High Very High
narcan 12 99.32 Very High Very High Very High
antidepressant 11 98.88 Very High Very High Very High
Lasting pain 4 98.84 Very High Very High Very High
withdrawal 4 98.64 Very High Very High Very High
sSRI 8 98.04 Very High Very High Very High
Desipramine 5 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 62 100.00 Very High Very High Very High
Stress 17 100.00 Very High Very High Very High
Pain 19 98.84 Very High Very High Very High
Hemorrhagic Shock 1 98.70 Very High Very High Very High
Cognitive Disorder 3 98.56 Very High Very High Very High
Lung Injury 2 97.36 Very High Very High Very High
Pancreatitis 1 96.64 Very High Very High Very High
Shock 18 95.52 Very High Very High Very High
INFLAMMATION 59 91.68 High High
Targeted Disruption 13 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, upregulation of a molecular target of CREB, BDNF, is abolished in the CREB-deficient mice after chronic administration of DMI.
Negative_regulation (abolished) of Positive_regulation (upregulation) of CREB associated with desipramine
1) Confidence 0.58 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943827 Disease Relevance 0.10 Pain Relevance 0.87
These results further emphasize the role of CREB in stress-induced gene expression and suggest furthermore that inhibition of stress-induced CREB activity may be a common mechanism of action of SSRIs underlying their antidepressive effect.
Negative_regulation (inhibition) of Positive_regulation (induced) of CREB associated with stress and ssri
2) Confidence 0.43 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20122921 Disease Relevance 0.62 Pain Relevance 0.53
However, it was unknown whether the selective inhibition of serotonin reuptake is sufficient for inhibition of stress-induced CREB activation, as it is for the clinical antidepressant effect.
Spec (whether) Negative_regulation (inhibition) of Spec (whether) Positive_regulation (activation) of CREB associated with stress, antidepressant and serotonin
3) Confidence 0.43 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20122921 Disease Relevance 0.58 Pain Relevance 0.71
This suggests that CREB activation in response to emotional events may be impaired in CaMKIV-/- mice as well.
Negative_regulation (impaired) of Positive_regulation (activation) of CREB
4) Confidence 0.41 Published 2005 Journal Mol Pain Section Body Doc Link PMC1079936 Disease Relevance 0.58 Pain Relevance 0.35
CREB activation by fear conditioning and synaptic potentiation in the amygdala and cortical areas was reduced or blocked.
Negative_regulation (reduced) of Positive_regulation (activation) of CREB in amygdala associated with anxiety disorder and amygdala
5) Confidence 0.35 Published 2002 Journal Nat. Neurosci. Section Abstract Doc Link 12006982 Disease Relevance 0.56 Pain Relevance 0.19
CREB activation by fear conditioning and synaptic potentiation in the amygdala and cortical areas was reduced or blocked.
Negative_regulation (blocked) of Positive_regulation (activation) of CREB in amygdala associated with anxiety disorder and amygdala
6) Confidence 0.35 Published 2002 Journal Nat. Neurosci. Section Abstract Doc Link 12006982 Disease Relevance 0.57 Pain Relevance 0.19
Pretreatment with DRz164 significant attenuated the morphine-induced activation of ERK and CREB in the frontal cortex, hippocampus, and striatum.
Negative_regulation (attenuated) of Positive_regulation (activation) of CREB in frontal cortex
7) Confidence 0.34 Published 2008 Journal Am J Drug Alcohol Abuse Section Body Doc Link 18850497 Disease Relevance 0 Pain Relevance 0
Antisense-pretreated mice showed decreased neurogranin expression, lack of morphine-induced phosphorylation of neurogranin and activation of CaMKII and CREB, and absence of naloxone-induced withdrawal jumping.
Negative_regulation (showed) of Positive_regulation (activation) of CREB associated with narcan, withdrawal and morphine
8) Confidence 0.32 Published 2007 Journal Brain Res. Section Abstract Doc Link 17306231 Disease Relevance 0.16 Pain Relevance 0.93
Targeted mutation of the EphB1 gene successfully prevented development of LTP and suppressed the associated activation (phosphorylation) of CaMKII, ERK, and CREB as well as increased c-Fos expression.
Negative_regulation (suppressed) of Positive_regulation (activation) of CREB associated with long-term potentiation
9) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.40
Pretreatment with DRz164 significant attenuated the morphine-induced activation of ERK and CREB in the frontal cortex, hippocampus, and striatum.
Negative_regulation (attenuated) of in striatum Positive_regulation (activation) of CREB in frontal cortex
10) Confidence 0.11 Published 2008 Journal Am J Drug Alcohol Abuse Section Body Doc Link 18850497 Disease Relevance 0 Pain Relevance 0
Pretreatment with DRz164 significant attenuated the morphine-induced activation of ERK and CREB in the frontal cortex, hippocampus, and striatum.
Negative_regulation (attenuated) of in hippocampus Positive_regulation (activation) of CREB in frontal cortex
11) Confidence 0.11 Published 2008 Journal Am J Drug Alcohol Abuse Section Body Doc Link 18850497 Disease Relevance 0 Pain Relevance 0
It was also demonstrated that PTX reduced histological lung injury and pulmonary neutrophil activity, in a model of hemorrhagic shock in rats [38], and the administration of PTX was associated with diminished NF-kappaB and enhanced CREB activation.
Negative_regulation (diminished) of Positive_regulation (activation) of CREB in neutrophil associated with lung injury and hemorrhagic shock
12) Confidence 0.07 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC3019217 Disease Relevance 1.38 Pain Relevance 0.82

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