INT102203

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Context Info
Confidence 0.71
First Reported 2002
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 35
Total Number 39
Disease Relevance 18.26
Pain Relevance 20.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
hippocampus 11
cortex 5
brain 3
DA neurons 1
amygdala 1
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 7 100.00 Very High Very High Very High
antidepressant 1121 99.92 Very High Very High Very High
B1 receptor 102 99.90 Very High Very High Very High
Hippocampus 825 99.84 Very High Very High Very High
fluoxetine 312 99.80 Very High Very High Very High
neurotrophin 3 8 99.80 Very High Very High Very High
depression 1399 99.68 Very High Very High Very High
Desipramine 170 99.50 Very High Very High Very High
nMDA receptor 27 99.26 Very High Very High Very High
amygdala 66 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 1787 99.68 Very High Very High Very High
Urological Neuroanatomy 275 99.48 Very High Very High Very High
Suicidal Behaviour 1976 99.38 Very High Very High Very High
Stress 552 99.20 Very High Very High Very High
Targeted Disruption 236 99.08 Very High Very High Very High
Disease 549 98.88 Very High Very High Very High
Cognitive Disorder 161 98.64 Very High Very High Very High
Obesity 64 98.50 Very High Very High Very High
Repression 34 97.20 Very High Very High Very High
Apoptosis 650 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that corticosterone selectively decreased the expression of transcripts II and IV, but not transcripts I or III, in both the frontal cortex and hippocampus.92 Two other recent studies suggest that immobilization stress decreases total BDNF expression, along with a specific decrease in exon IV in the hippocampus96 and hypothalamus.97 These studies suggest that the decrease of BDNF mRNA expression by glucocorticoids may be due to a decrease in expression of the specific BDNF transcripts that contain exons II and IV.


Transcription (expression) of BDNF in hippocampus associated with stress, urological neuroanatomy and hippocampus
1) Confidence 0.71 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.59 Pain Relevance 0.29
The very first study that examined the role of stress was from Smith and colleagues,83 who demonstrated that immobilization stress used for 1 or 7 days (for 2 hours per day) significantly decreased BDNF mRNA expression in the hippocampus.
Transcription (expression) of BDNF in hippocampus associated with stress and hippocampus
2) Confidence 0.71 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.96 Pain Relevance 0.28
Interesting results were noted when individual BDNF transcripts were examined after antidepressant treatment of corticosterone-implanted rats: the antidepressants were able to increase mRNA levels of only those BDNF transcripts that were affected when the respective antidepressant was given to healthy rats without corticosterone pellet implantation.
Transcription (levels) of BDNF associated with antidepressant
3) Confidence 0.71 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.54 Pain Relevance 0.94
Recently, Fuchikami et al179 reported that single immobilization stress (a model for depression) decreased the levels of BDNF mRNA, which was associated with decreased expression of exons I and IV.
Transcription (levels) of BDNF associated with stress and depression
4) Confidence 0.71 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.67 Pain Relevance 0.14
In addition to adult suicide subjects, we recently examined the expression of BDNF in postmortem brain samples obtained from teenaged suicide subjects.184 Protein and mRNA expression of BDNF was determined in samples from the PFC, Brodmann’s area 9, and hippocampus obtained from 22 teenaged suicide victims and 22 matched nonpsychiatric healthy control subjects.
Transcription (expression) of BDNF in hippocampus associated with suicidal behaviour and hippocampus
5) Confidence 0.62 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.95 Pain Relevance 0.30
We determined mRNA and protein expression of BDNF in the PFC (Brodmann’s area 9) and hippocampus from specimens obtained from 21 fully characterized suicide subjects and 27 nonpsychiatric healthy control subjects.181 We observed that mRNA level of BDNF was significantly reduced, independently and as a ratio to neuron-specific enolase (a housekeeping gene), in both the PFC and hippocampus of suicide subjects compared with nonpsychiatric healthy control subjects.
Spec (determined) Transcription (expression) of BDNF in neuron associated with suicidal behaviour and hippocampus
6) Confidence 0.59 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.36 Pain Relevance 0.37
Interesting results were noted when individual BDNF transcripts were examined after antidepressant treatment of corticosterone-implanted rats: the antidepressants were able to increase mRNA levels of only those BDNF transcripts that were affected when the respective antidepressant was given to healthy rats without corticosterone pellet implantation.
Transcription (transcripts) of BDNF associated with antidepressant
7) Confidence 0.53 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.52 Pain Relevance 0.86
Another recent study by Altieri et al118 also showed no effect of long-term fluoxetine treatment on BDNF transcripts in the hippocampus.
Transcription (transcripts) of BDNF in hippocampus associated with hippocampus and fluoxetine
8) Confidence 0.53 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.30 Pain Relevance 1.09
In another study, Dias et al102 examined the effects of long-term antidepressants on BDNF transcript levels in the rat hippocampus, amygdala, and cortex.
Transcription (levels) of BDNF in amygdala associated with antidepressant, hippocampus and amygdala
9) Confidence 0.53 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.26 Pain Relevance 1.24
Thus, it appears that antidepressants are effective in causing an increase in total BDNF expression in corticosterone-treated rats; however, the mechanisms for the down-regulation of BDNF transcripts by corticosterone and those that affect their upregulation by antidepressants are quite different.


Transcription (transcripts) of BDNF associated with antidepressant
10) Confidence 0.53 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.31 Pain Relevance 0.61
The expression of brain-derived neurotrophic factor (BDNF) was detected by immunohistochemistry, and mRNA expression of BDNF and cAMP response element-binding protein (CREB) analyzed by reverse transcription-polymerase chain reaction (RT-PCR).
Spec (analyzed) Transcription (expression) of BDNF in brain
11) Confidence 0.52 Published 2009 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 19248161 Disease Relevance 0.95 Pain Relevance 0.34
Combined treatment produced no effect on BDNF mRNA expression.
Transcription (expression) of BDNF
12) Confidence 0.51 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16740621 Disease Relevance 0.05 Pain Relevance 0.66
TrkB-deficient humans show learning difficulties and severe obesity [168]. bdnf-deficient heterozygous mice are obese, with high leptin and insulin levels which correct with diet alone [169]. bdnf mRNA or protein is expressed in the VMH, DMH and lateral hypothalamus, but not the arcuate nucleus [169,170].
Neg (not) Transcription (expressed) of bdnf in hypothalamus associated with obesity
13) Confidence 0.49 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.41 Pain Relevance 0.06
Our depression model caused a sustained reduction in BDNF mRNA expression in hippocampus (up to 24 h).
Transcription (expression) of BDNF in hippocampus associated with depression and hippocampus
14) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.69 Pain Relevance 0.85
B1 receptor and BDNF mRNA expression was carried out through fluorescence-based real-time PCR.
Transcription (expression) of BDNF associated with b1 receptor
15) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.07 Pain Relevance 0.12
Of note, BDNF mRNA expression was not significantly altered by previous administration of the selective B1 receptor antagonist SSR240612.
Transcription (expression) of BDNF associated with antagonist and b1 receptor
16) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.74 Pain Relevance 0.86
We observed higher BDNF mRNA levels in the fasting MTII injected mice than in the control fasting mice (figure 7A).
Transcription (levels) of BDNF associated with bdmf
17) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.41
To examine how BDNF is regulated in response to antidepressants, we administered different classes of antidepressants (serotonin uptake blocker, fluoxetine, norepinephrine blocker, desipramine, monoamine oxidase inhibitor, or phenelzine) to healthy rats and examined whether antidepressants regulate the expression of BDNF via specific BDNF transcript(s).92 We observed very interesting results such that treatment of healthy rats with desipramine or phenelzine increased mRNA levels of total BDNF in both the frontal cortex and hippocampus, whereas fluoxetine increased the mRNA level of BDNF only in the hippocampus.92 More interestingly, when we examined the effects of antidepressants on the expression of individual exons containing BDNF transcripts, we found that desipramine specifically increased exons I and III in both the frontal cortex and hippocampus; fluoxetine increased only exon II in the hippocampus; and phenelzine effectively increased exons I and IV in the hippocampus but only exon I in the frontal cortex.
Transcription (levels) of BDNF in hippocampus associated with desipramine, antidepressant, urological neuroanatomy, hippocampus, serotonin, monoamine and fluoxetine
18) Confidence 0.46 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.27 Pain Relevance 1.29
Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription.177 On the other hand, membrane depolarization causes increased BDNF transcription, which involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter,177,178 which suggests that DNA methylation-related chromatin remodeling is important for activity-dependent Bdnf gene regulation.
Transcription (transcription) of BDNF associated with repression
19) Confidence 0.46 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.72 Pain Relevance 0.18
To examine how BDNF is regulated in response to antidepressants, we administered different classes of antidepressants (serotonin uptake blocker, fluoxetine, norepinephrine blocker, desipramine, monoamine oxidase inhibitor, or phenelzine) to healthy rats and examined whether antidepressants regulate the expression of BDNF via specific BDNF transcript(s).92 We observed very interesting results such that treatment of healthy rats with desipramine or phenelzine increased mRNA levels of total BDNF in both the frontal cortex and hippocampus, whereas fluoxetine increased the mRNA level of BDNF only in the hippocampus.92 More interestingly, when we examined the effects of antidepressants on the expression of individual exons containing BDNF transcripts, we found that desipramine specifically increased exons I and III in both the frontal cortex and hippocampus; fluoxetine increased only exon II in the hippocampus; and phenelzine effectively increased exons I and IV in the hippocampus but only exon I in the frontal cortex.
Transcription (level) of BDNF in hippocampus associated with desipramine, antidepressant, urological neuroanatomy, hippocampus, serotonin, monoamine and fluoxetine
20) Confidence 0.46 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.27 Pain Relevance 1.37

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