INT102204

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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.74
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
hippocampus 2
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 50 99.68 Very High Very High Very High
depression 94 98.84 Very High Very High Very High
antidepressant 153 97.92 Very High Very High Very High
midbrain 4 97.48 Very High Very High Very High
Desipramine 18 97.04 Very High Very High Very High
Eae 7 93.24 High High
fluoxetine 27 91.68 High High
Neurotransmitter 3 83.24 Quite High
cerebral cortex 1 69.36 Quite High
monoamine 8 68.32 Quite High
Disease Link Frequency Relevance Heat
Depression 154 98.84 Very High Very High Very High
Stress 31 98.08 Very High Very High Very High
Repression 2 97.48 Very High Very High Very High
Death 5 95.92 Very High Very High Very High
Apoptosis 7 73.84 Quite High
Suicidal Behaviour 123 61.28 Quite High
Frailty 3 53.72 Quite High
Injury 1 39.24 Quite Low
Cognitive Disorder 4 37.24 Quite Low
Urological Neuroanatomy 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, upregulation of a molecular target of CREB, BDNF, is abolished in the CREB-deficient mice after chronic administration of DMI.
Positive_regulation (upregulation) of Regulation (target) of BDNF associated with desipramine
1) Confidence 0.43 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943827 Disease Relevance 0.10 Pain Relevance 0.87
Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription.177 On the other hand, membrane depolarization causes increased BDNF transcription, which involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter,177,178 which suggests that DNA methylation-related chromatin remodeling is important for activity-dependent Bdnf gene regulation.
Positive_regulation (dependent) of Regulation (regulation) of Bdnf gene associated with repression
2) Confidence 0.43 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.77 Pain Relevance 0.17
For example, long-term administration of antidepressants in animals upregulates the production of brain BDNF,5 and infusion of BDNF itself into the midbrain has an antidepressant-like influence in animal models of depression.11 In a human postmortem study, Chen et al.12 found that BDNF immunoreactivity was higher in the hippocampus of depressed subjects being treated with antidepressant medication at the time of death than in that of untreated controls.
Positive_regulation (higher) of Regulation (immunoreactivity) of BDNF in hippocampus associated with antidepressant, depression, hippocampus, midbrain and death
3) Confidence 0.41 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0.87 Pain Relevance 0.63

General Comments

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