INT102205

Context Info Confidence 0.50 First Reported 2002 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 3.77 Pain Relevance 1.91

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)

Anatomy Link Frequency neuron 2 spine 2 Bdnf (Mus musculus)

Pain Link Frequency Relevance Heat antidepressant 76 98.82 Hippocampus 58 98.80 Nerve growth factor 60 97.76 Desipramine 15 97.60 Eae 11 93.24 fluoxetine 26 91.68 long-term potentiation 21 90.48 Pyramidal cell 6 80.16 depression 79 78.08 Neurotransmitter 6 69.00

Disease Link Frequency Relevance Heat Targeted Disruption 25 99.64 Neurodegenerative Disease 43 99.24 Suicidal Behaviour 123 98.34 Stress 59 98.08 Aging 6 97.64 Injury 17 96.84 Sprains And Strains 3 95.92 Brain Injury 6 92.72 Apoptosis 143 85.12 Depression 101 78.08

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We determined mRNA and protein expression of BDNF in the PFC (Brodmann’s area 9) and hippocampus from specimens obtained from 21 fully characterized suicide subjects and 27 nonpsychiatric healthy control subjects.181 We observed that mRNA level of BDNF was significantly reduced, independently and as a ratio to neuron-specific enolase (a housekeeping gene), in both the PFC and hippocampus of suicide subjects compared with nonpsychiatric healthy control subjects.

Negative_regulation (reduced) of Positive_regulation (level) of BDNF in neuron associated with suicidal behaviour and hippocampus

1) Confidence 0.50 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.50 Pain Relevance 0.35

However, upregulation of a molecular target of CREB, BDNF, is abolished in the CREB-deficient mice after chronic administration of DMI.

Negative_regulation (abolished) of Positive_regulation (upregulation) of BDNF associated with desipramine

2) Confidence 0.40 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943827 Disease Relevance 0.10 Pain Relevance 0.87

We investigated the role of BDNF signaling in antidepressant-induced neurogenesis by using transgenic mice with either reduced BDNF levels (BDNF+/-) or impaired trkB activation (trkB.T1-overexpressing mice).

Negative_regulation (reduced) of Positive_regulation (activation) of BDNF associated with targeted disruption, antidepressant and neurodegenerative disease

3) Confidence 0.37 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15689544 Disease Relevance 0.54 Pain Relevance 0.21

The increase in BDNF was diminished in aged rats, suggesting reduced spontaneous healing with aging [70,71].

Negative_regulation (diminished) of Positive_regulation (increase) of BDNF associated with aging

4) Confidence 0.24 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 1.30 Pain Relevance 0.34

For example, in vitro studies have shown that PKA localizes to dendritic spines and is involved in actin reorganization upon NMDAR activation (Gomez et al. 2002; Hsieh-Wilson et al. 2003), while ERK controls neurite outgrowth (Chierzi et al. 2005) and is required for BDNF-dependent increases in spine density (Alonso et al. 2004).

Negative_regulation (required) of Positive_regulation (increases) of BDNF-dependent in spine

5) Confidence 0.17 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0 Pain Relevance 0

decrease the activity of cyclic AMP-response element binding protein (CREB) and downstream gene expression, such as the activation of the BDNF promoter [113].

Negative_regulation (decrease) of Positive_regulation (activation) of BDNF promoter

6) Confidence 0.14 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.32 Pain Relevance 0.13

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