INT102206

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2011
Negated 4
Speculated 15
Reported most in Body
Documents 37
Total Number 57
Disease Relevance 28.54
Pain Relevance 28.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
hippocampus 7
brain 6
amygdala 2
neuronal 2
cortex 2
Bdnf (Mus musculus)
Bdnf - V66M (4)
Pain Link Frequency Relevance Heat
antidepressant 2521 100.00 Very High Very High Very High
fluoxetine 548 100.00 Very High Very High Very High
Desipramine 285 100.00 Very High Very High Very High
Serotonin 125 100.00 Very High Very High Very High
bDMF 89 100.00 Very High Very High Very High
Inflammation 22 99.84 Very High Very High Very High
Dopamine 277 99.68 Very High Very High Very High
Nerve growth factor 146 99.56 Very High Very High Very High
gABA 11 99.54 Very High Very High Very High
sSRI 190 99.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 810 99.98 Very High Very High Very High
Infection 96 99.88 Very High Very High Very High
Suicidal Behaviour 2957 99.84 Very High Very High Very High
INFLAMMATION 28 99.84 Very High Very High Very High
Neurodegenerative Disease 131 99.80 Very High Very High Very High
Targeted Disruption 453 99.68 Very High Very High Very High
Depression 3028 99.08 Very High Very High Very High
Alzheimer's Dementia 78 99.06 Very High Very High Very High
Injury 55 99.04 Very High Very High Very High
Urological Neuroanatomy 410 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, chronic amitriptyline (a tricyclic antidepressant) in rats increased BDNF protein in the hippocampus.50 However, another study showed that chronic fluoxetine or desipramine administration in rats had no effect on BDNF protein in the hippocampus.51 These findings emphasise the importance of using a single antidepressant in BDNF pharmacogenetic studies.52
Neg (no) Spec (findings) Regulation (effect) of BDNF in hippocampus associated with antidepressant, desipramine, hippocampus, tricyclic antidepressant, endep and fluoxetine
1) Confidence 0.62 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0 Pain Relevance 0.80
In another study, Dias et al102 examined the effects of long-term antidepressants on BDNF transcript levels in the rat hippocampus, amygdala, and cortex.
Spec (examined) Regulation (effects) of BDNF in amygdala associated with antidepressant, hippocampus and amygdala
2) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.27 Pain Relevance 1.25
Altogether, these studies suggest that although BDNF expression is repressed or induced by stress or antidepressants by different mechanisms, epigenetic regulation of the BDNF gene plays an important role in depression and in the mechanisms of action of antidepressants.


Regulation (regulation) of BDNF gene associated with stress, antidepressant and depression
3) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.15 Pain Relevance 0.33
On a molecular level, BDNF is highly regulated.
Regulation (regulated) of BDNF
4) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.44 Pain Relevance 0.26
Thus, it appears that antidepressants are effective in causing an increase in total BDNF expression in corticosterone-treated rats; however, the mechanisms for the down-regulation of BDNF transcripts by corticosterone and those that affect their upregulation by antidepressants are quite different.


Regulation (regulation) of BDNF associated with antidepressant
5) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.31 Pain Relevance 0.61
To examine the molecular basis of stress regulation of BDNF, we determined mRNA levels of exons I through IV.
Spec (examine) Regulation (regulation) of BDNF associated with stress
6) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.42 Pain Relevance 0.20
It has been suggested that epigenetic modulation of the Bdnf and Trkb genes may contribute to their altered expression and functioning.
Regulation (modulation) of Bdnf
7) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2732010 Disease Relevance 1.13 Pain Relevance 0.30
Using in situ hybridization, we examined the effects of chronic treatment with fluoxetine (FLU) or desipramine (DMI) on BDNF, CaMKKalpha and CaMKKbeta mRNAs in the hippocampus of wild-type (Wt) and transgenic (TG) mice characterized by glucocorticoid receptor (GR) dysfunction.
Spec (examined) Regulation (effects) of BDNF in hippocampus associated with targeted disruption, desipramine, hippocampus and fluoxetine
8) Confidence 0.60 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15555640 Disease Relevance 0.54 Pain Relevance 0.85
To examine how BDNF is regulated in response to antidepressants, we administered different classes of antidepressants (serotonin uptake blocker, fluoxetine, norepinephrine blocker, desipramine, monoamine oxidase inhibitor, or phenelzine) to healthy rats and examined whether antidepressants regulate the expression of BDNF via specific BDNF transcript(s).92 We observed very interesting results such that treatment of healthy rats with desipramine or phenelzine increased mRNA levels of total BDNF in both the frontal cortex and hippocampus, whereas fluoxetine increased the mRNA level of BDNF only in the hippocampus.92 More interestingly, when we examined the effects of antidepressants on the expression of individual exons containing BDNF transcripts, we found that desipramine specifically increased exons I and III in both the frontal cortex and hippocampus; fluoxetine increased only exon II in the hippocampus; and phenelzine effectively increased exons I and IV in the hippocampus but only exon I in the frontal cortex.
Spec (examine) Regulation (regulated) of BDNF in hippocampus associated with desipramine, antidepressant, urological neuroanatomy, hippocampus, serotonin, monoamine and fluoxetine
9) Confidence 0.53 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.33 Pain Relevance 1.37
Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription.177 On the other hand, membrane depolarization causes increased BDNF transcription, which involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter,177,178 which suggests that DNA methylation-related chromatin remodeling is important for activity-dependent Bdnf gene regulation.
Regulation (regulation) of Bdnf gene associated with repression
10) Confidence 0.53 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.72 Pain Relevance 0.17
Although some of these discrepancies can be attributed to route of administration or doses of drugs, these findings suggest that there is no unified mechanism for the regulation of BDNF exon(s) by antidepressants and that various classes of antidepressants may affect BDNF exon expression differently.
Regulation (regulation) of BDNF associated with antidepressant
11) Confidence 0.53 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.32 Pain Relevance 0.98
Chronic treatment with desipramine and fluoxetine modulate BDNF, CaMKKalpha and CaMKKbeta mRNA levels in the hippocampus of transgenic mice expressing antisense RNA against the glucocorticoid receptor.
Regulation (modulate) of BDNF in hippocampus associated with targeted disruption, desipramine, hippocampus and fluoxetine
12) Confidence 0.52 Published 2004 Journal Neuropharmacology Section Title Doc Link 15555640 Disease Relevance 0.40 Pain Relevance 0.71
Since BDNF is regulated by neuronal synaptic activity [37, 38], the positive effect of lutein on BDNF may have been through preservation of the synaptophysin level and the subsequent neuronal synaptic activity in the retina of diabetic mice.
Regulation (regulated) of BDNF in neuronal associated with diabetes mellitus
13) Confidence 0.48 Published 2010 Journal Diabetologia Section Body Doc Link PMC2850533 Disease Relevance 0.58 Pain Relevance 0.04
For example, recent meta-analysis studies have revealed a sexually dimorphic effect of the BDNF Val66Met polymorphism on susceptibility to MDD20 and to Alzheimer's disease.63 Interactions between age/gender and BDNF should therefore be considered in future antidepressant pharmacogenetic studies.



Regulation (effect) of BDNF (V66M) associated with antidepressant and disease
14) Confidence 0.45 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0.88 Pain Relevance 0.25
However, in a subsequent genetic study, we found an association between BDNF Val66Met polymorphism and geriatric depression, chiefly in males.19 These findings are in line with a recent meta-analysis of 14 studies involving 2812 MDD cases and 10843 non-depressed controls, which revealed that the BDNF Val66Met polymorphism is not significantly associated with MDD; however, male gender and old age do have an impact on the association.20

PHARMACOGENETIC STUDY OF BDNF AND THERAPEUTIC RESPONSE TO ANTIDEPRESSANTS

Regulation (association) of BDNF (V66M) associated with depression
15) Confidence 0.45 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0.75 Pain Relevance 0.19
However, it is unknown whether BDNF overactivity may affect antidepressant response.
Spec (may) Regulation (affect) of BDNF associated with antidepressant
16) Confidence 0.45 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0.38 Pain Relevance 0.69
Recently, Frodl et al155 examined the effect of the BDNF Val66Met polymorphism on hippocampal and amygdala volumes in patients with depression and in healthy control subjects.
Spec (examined) Regulation (effect) of BDNF Val66Met (V66M) in amygdala associated with depression and amygdala
17) Confidence 0.45 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.83 Pain Relevance 0.35
Another recent study by Altieri et al118 also showed no effect of long-term fluoxetine treatment on BDNF transcripts in the hippocampus.
Neg (no) Regulation (effect) of BDNF in hippocampus associated with hippocampus and fluoxetine
18) Confidence 0.45 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.30 Pain Relevance 1.15
Interesting results were noted when individual BDNF transcripts were examined after antidepressant treatment of corticosterone-implanted rats: the antidepressants were able to increase mRNA levels of only those BDNF transcripts that were affected when the respective antidepressant was given to healthy rats without corticosterone pellet implantation.
Regulation (affected) of BDNF associated with antidepressant
19) Confidence 0.45 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.54 Pain Relevance 0.97
It is also not known whether BDNF is regulated downstream of factors that control fungiform placode development.
Spec (whether) Regulation (regulated) of BDNF in placode associated with bdmf
20) Confidence 0.44 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.10 Pain Relevance 0.21

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