INT102207

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.49
Pain Relevance 7.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
hippocampus 7
cortex 3
brain 2
mesencephalon 2
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 7 100.00 Very High Very High Very High
fluoxetine 106 99.98 Very High Very High Very High
antidepressant 391 99.72 Very High Very High Very High
Desipramine 55 99.70 Very High Very High Very High
Hippocampus 265 99.58 Very High Very High Very High
antagonist 15 98.48 Very High Very High Very High
gABA 2 97.64 Very High Very High Very High
Substantia nigra 8 94.92 High High
monoamine 27 94.82 High High
Serotonin 12 93.32 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 85 99.48 Very High Very High Very High
Stress 205 99.00 Very High Very High Very High
Cognitive Disorder 54 98.92 Very High Very High Very High
Repression 12 97.20 Very High Very High Very High
Disease 260 91.76 High High
Neurodegenerative Disease 106 89.60 High High
Depression 568 86.88 High High
Suicidal Behaviour 623 70.92 Quite High
Frailty 10 60.16 Quite High
Apoptosis 306 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interesting results were noted when individual BDNF transcripts were examined after antidepressant treatment of corticosterone-implanted rats: the antidepressants were able to increase mRNA levels of only those BDNF transcripts that were affected when the respective antidepressant was given to healthy rats without corticosterone pellet implantation.
Positive_regulation (increase) of Transcription (levels) of BDNF associated with antidepressant
1) Confidence 0.69 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.54 Pain Relevance 0.94
Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription.177 On the other hand, membrane depolarization causes increased BDNF transcription, which involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter,177,178 which suggests that DNA methylation-related chromatin remodeling is important for activity-dependent Bdnf gene regulation.
Positive_regulation (causes) of Transcription (transcription) of BDNF associated with repression
2) Confidence 0.40 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.72 Pain Relevance 0.18
To examine how BDNF is regulated in response to antidepressants, we administered different classes of antidepressants (serotonin uptake blocker, fluoxetine, norepinephrine blocker, desipramine, monoamine oxidase inhibitor, or phenelzine) to healthy rats and examined whether antidepressants regulate the expression of BDNF via specific BDNF transcript(s).92 We observed very interesting results such that treatment of healthy rats with desipramine or phenelzine increased mRNA levels of total BDNF in both the frontal cortex and hippocampus, whereas fluoxetine increased the mRNA level of BDNF only in the hippocampus.92 More interestingly, when we examined the effects of antidepressants on the expression of individual exons containing BDNF transcripts, we found that desipramine specifically increased exons I and III in both the frontal cortex and hippocampus; fluoxetine increased only exon II in the hippocampus; and phenelzine effectively increased exons I and IV in the hippocampus but only exon I in the frontal cortex.
Positive_regulation (increased) of Transcription (levels) of BDNF in hippocampus associated with desipramine, antidepressant, urological neuroanatomy, hippocampus, serotonin, monoamine and fluoxetine
3) Confidence 0.40 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.27 Pain Relevance 1.30
To examine how BDNF is regulated in response to antidepressants, we administered different classes of antidepressants (serotonin uptake blocker, fluoxetine, norepinephrine blocker, desipramine, monoamine oxidase inhibitor, or phenelzine) to healthy rats and examined whether antidepressants regulate the expression of BDNF via specific BDNF transcript(s).92 We observed very interesting results such that treatment of healthy rats with desipramine or phenelzine increased mRNA levels of total BDNF in both the frontal cortex and hippocampus, whereas fluoxetine increased the mRNA level of BDNF only in the hippocampus.92 More interestingly, when we examined the effects of antidepressants on the expression of individual exons containing BDNF transcripts, we found that desipramine specifically increased exons I and III in both the frontal cortex and hippocampus; fluoxetine increased only exon II in the hippocampus; and phenelzine effectively increased exons I and IV in the hippocampus but only exon I in the frontal cortex.
Positive_regulation (increased) of Transcription (level) of BDNF in hippocampus associated with desipramine, antidepressant, urological neuroanatomy, hippocampus, serotonin, monoamine and fluoxetine
4) Confidence 0.40 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.27 Pain Relevance 1.37
Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription.177 On the other hand, membrane depolarization causes increased BDNF transcription, which involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter,177,178 which suggests that DNA methylation-related chromatin remodeling is important for activity-dependent Bdnf gene regulation.
Positive_regulation (increased) of Transcription (transcription) of BDNF associated with repression
5) Confidence 0.40 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.72 Pain Relevance 0.18
In separate experiments, Northern blot analysis showed that a 14-day treatment with imipramine (10 mg/kg b.i.d.) increased brain-derived neurotrophic factor (BDNF) mRNA expression in the cortex, whereas neramexane (5 mg/kg b.i.d.) decreased it.
Positive_regulation (increased) of Transcription (expression) of BDNF in cortex
6) Confidence 0.39 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16740621 Disease Relevance 0.06 Pain Relevance 0.67
cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs.
Positive_regulation (upregulation) of Transcription (transcription) of brain-derived neurotrophic factor in brain associated with antidepressant
7) Confidence 0.38 Published 2002 Journal J. Neurosci. Section Title Doc Link 11943827 Disease Relevance 0.06 Pain Relevance 0.73
We observed higher BDNF mRNA levels in the fasting MTII injected mice than in the control fasting mice (figure 7A).
Positive_regulation (higher) of Transcription (levels) of BDNF associated with bdmf
8) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.41
Accordingly, long-term antidepressant treatment has been shown to increase BDNF protein and mRNA levels [19-21] and reverse the stress-induced decrease in BDNF [21,22].
Positive_regulation (increase) of Transcription (levels) of BDNF associated with stress and antidepressant
9) Confidence 0.27 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 1.11 Pain Relevance 0.64
Increased BDNF mRNA levels in the ventral mesencephalon in Pten KO animals, suggests that striatal afferents may have increased availability to trophic support in KO animals.
Positive_regulation (Increased) of Transcription (levels) of BDNF in mesencephalon
10) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.39
Also, Greenberg and colleagues reported that activity-dependent phosphorylation of MeCP2 at serine 421 is mediated by CaMKII and phosphorylation of the site controls the ability of MeCP2 to regulate activity-dependent BDNF transcription and dendritic growth [35], raising the possibility that the immature DG of the mutant mice is due to a disruption of the program that regulates gene expression triggered by this pathway.
Positive_regulation (dependent) of Transcription (transcription) of BDNF
11) Confidence 0.27 Published 2008 Journal Mol Brain Section Body Doc Link PMC2562999 Disease Relevance 0 Pain Relevance 0.08
The drug increased NGF and BDNF mRNA and protein levels in the rat cortex and hippocampus, and improved cognitive function in the patients.
Positive_regulation (increased) of Transcription (levels) of BDNF in hippocampus associated with cognitive disorder and hippocampus
12) Confidence 0.12 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.88 Pain Relevance 0.15
The drug increased NGF and BDNF mRNA and protein levels in the rat cortex and hippocampus, and improved cognitive function in the patients.
Positive_regulation (increased) of in cortex Transcription (levels) of BDNF in hippocampus associated with cognitive disorder and hippocampus
13) Confidence 0.04 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.88 Pain Relevance 0.15

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