INT102209

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.46
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) signal transduction (Drd2) plasma membrane (Drd2)
signal transducer activity (Drd2)
Anatomy Link Frequency
striatum 4
NAc 2
Drd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 181 100.00 Very High Very High Very High
Nucleus accumbens 11 99.32 Very High Very High Very High
Serotonin 5 97.88 Very High Very High Very High
cocaine 13 97.04 Very High Very High Very High
Opioid 3 96.40 Very High Very High Very High
Morphine 9 96.12 Very High Very High Very High
dopamine receptor 14 88.80 High High
depression 4 88.68 High High
fluoxetine 1 83.84 Quite High
Ventral tegmentum 2 73.32 Quite High
Disease Link Frequency Relevance Heat
Depression 7 98.30 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 16 55.68 Quite High
Disease 19 55.32 Quite High
Cognitive Disorder 3 37.36 Quite Low
Starvation 2 31.12 Quite Low
Eating Disorder 3 28.40 Quite Low
Anorexia 4 6.00 Low Low
Sprains And Strains 9 5.00 Very Low Very Low Very Low
Obesity 6 5.00 Very Low Very Low Very Low
Parkinson's Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Extracellular DA levels were measured in the striatum of mice lacking D2R expression (D2R-/-) by in vivo microdialysis after administration of the psychostimulant cocaine and the opioid morphine.
Negative_regulation (lacking) of Neg (lacking) Gene_expression (expression) of D2R in striatum associated with dopamine, opioid, morphine and cocaine
1) Confidence 0.59 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943831 Disease Relevance 0 Pain Relevance 0.68
Results obtained using complementary microdialysis and voltammetry analyses show that the autoreceptor function regulating DA release is totally abolished in the absence of D2R, despite unchanged DA uptake and basal DA efflux.
Negative_regulation (abolished) of Neg (absence) Gene_expression (absence) of D2R associated with dopamine
2) Confidence 0.43 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943831 Disease Relevance 0 Pain Relevance 0.91
Extracellular DA levels were measured in the striatum of mice lacking D2R expression (D2R-/-) by in vivo microdialysis after administration of the psychostimulant cocaine and the opioid morphine.
Negative_regulation (lacking) of Neg (lacking) Gene_expression (expression) of D2R in striatum associated with dopamine, opioid, morphine and cocaine
3) Confidence 0.43 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943831 Disease Relevance 0 Pain Relevance 0.68
The administration of methylphenidate
   to these subjects produced a feeling of aversion, as opposed to what happened when
   methylphenidate was administered to people with low levels of D2 receptor expression; in these
   subjects the drug produced a pleasure feeling 174.
   
Negative_regulation (levels) of Gene_expression (expression) of D2
4) Confidence 0.37 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0.11 Pain Relevance 0.39
We show here that ablation of Rxrgamma in mice leads to depressive-like behaviors including increased despair and anhedonia, which were accompanied by reduced expression of dopamine D2 receptor in the shell of nucleus accumbens (NAc) and altered serotonin signaling.
Negative_regulation (reduced) of Gene_expression (expression) of dopamine D2 receptor in NAc associated with nucleus accumbens, dopamine, depression and serotonin
5) Confidence 0.17 Published 2010 Journal Neuron Section Abstract Doc Link 20620876 Disease Relevance 0.35 Pain Relevance 0.50

General Comments

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