INT102231

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.14
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (HBM)
Anatomy Link Frequency
platelets 1
central nervous system 1
PGE2 1
HBM (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 3 100.00 Very High Very High Very High
tolerance 18 99.70 Very High Very High Very High
Inflammation 16 99.68 Very High Very High Very High
Central nervous system 17 99.04 Very High Very High Very High
cva 12 89.60 High High
Serotonin 1 89.24 High High
bradykinin 1 88.24 High High
headache 2 71.44 Quite High
cytokine 3 70.00 Quite High
addiction 1 59.88 Quite High
Disease Link Frequency Relevance Heat
Congenital Anomalies 12 100.00 Very High Very High Very High
Hemorrhage 3 99.88 Very High Very High Very High
Impaired Glucose Tolerance 16 99.70 Very High Very High Very High
Neurogenic Inflammation 1 99.68 Very High Very High Very High
Hyperglycemia 4 98.30 Very High Very High Very High
Renal Disease 4 98.24 Very High Very High Very High
INFLAMMATION 19 98.14 Very High Very High Very High
Death 7 97.36 Very High Very High Very High
Disease 39 97.28 Very High Very High Very High
Diabetes Mellitus 105 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
0.654, perceived seriousness (HBM2) ?
Localization (seriousness) of HBM2
1) Confidence 0.60 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872324 Disease Relevance 0 Pain Relevance 0
The authors review the available evidence linking these factors to the development of inflammatory lesions of the cerebral vasculature, emphasizing: 1) neurogenic inflammation due to massive release of sensory nerve neuropeptides; 2) hemoglobin from lysed erythrocytes, which creates functional lesions of endothelial and smooth muscle cells; 3) activity, expression and metabolites of lipoxygenases cyclooxygenases and nitric oxide synthases; 4) the possible role of endothelin-1 as a pro-inflammatory agent; 5) serotonin, histamine and bradykinin which are especially involved in blood-brain barrier disruption; 6) the prothrombotic and pro-inflammatory action of complement and thrombin towards endothelium; 7) the multiple actions of activated platelets, including platelet-derived growth factor production; 8) the presence of perivascular and intramural macrophages and granulocytes and their interaction with adhesion molecules; 9) the evolution, origins, and effects of pro-inflammatory cytokines, especially IL-1, TNF-alpha and IL-6.
Localization (release) of hemoglobin in platelets associated with inflammation, neuropeptide, neurogenic inflammation, bradykinin, serotonin, adhesions and cytokine
2) Confidence 0.11 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11949877 Disease Relevance 1.08 Pain Relevance 0.59
mol/L) or hematological abnormalities (hemoglobin ?
Localization (abnormalities) of hemoglobin associated with congenital anomalies
3) Confidence 0.09 Published 2006 Journal Trials Section Body Doc Link PMC1563476 Disease Relevance 0.35 Pain Relevance 0
Furthermore, control of postprandial hyperglycemia has been shown to provide cardiovascular benefits, and to contribute to the overall decrease of hemoglobin A1c, something that has been clearly shown to reduce microvascular disease in both type 1 and type 2 diabetes [52,53].
Localization (decrease) of hemoglobin associated with hyperglycemia, diabetes mellitus and disease
4) Confidence 0.04 Published 2005 Journal Nutr Metab (Lond) Section Body Doc Link PMC1188071 Disease Relevance 1.05 Pain Relevance 0
The red cell [Ca2+]i elevation induced by LPA, PGE2, and other agents stimulates erythroid suicidal cell death (eryptosis) by increasing annexin V externalization, promoting erythrophagocytosis by the reticuloendothelial system without lytic release of toxic free hemoglobin [57].
Localization (release) of hemoglobin in PGE2 associated with death
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806905 Disease Relevance 0.15 Pain Relevance 0.03
A number of central nervous system conditions may lead to localized bleeding with hemoglobin release with the induction of heme sequestering proteins.
Localization (release) of hemoglobin in central nervous system associated with hemorrhage and central nervous system
6) Confidence 0.03 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 1.64 Pain Relevance 0.13
Primary outcome indexes include: oral glucose tolerance test; insulin releasing test; glycosylated hemoglobin (HA1c).
Localization (releasing) of hemoglobin associated with tolerance and impaired glucose tolerance
7) Confidence 0.01 Published 2010 Journal Trials Section Abstract Doc Link PMC2842259 Disease Relevance 0.76 Pain Relevance 0.12
These reactants will detect hemoglobin at concentrations of 0.3 mg/l, and a similar concentration would be predicted for myoglobin [112].
Localization (detect) of hemoglobin
8) Confidence 0.01 Published 2005 Journal Crit Care Section Body Doc Link PMC1175909 Disease Relevance 1.10 Pain Relevance 0

General Comments

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