INT102234

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Context Info
Confidence 0.65
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 21
Disease Relevance 9.29
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR2) signal transduction (ESR2) mitochondrion (ESR2)
nucleus (ESR2) enzyme binding (ESR2) DNA binding (ESR2)
Anatomy Link Frequency
endothelial cells 4
lymph nodes 1
joint 1
stroma 1
brain 1
ESR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 1 99.60 Very High Very High Very High
opiate 4 99.16 Very High Very High Very High
Paracetamol 26 98.74 Very High Very High Very High
Morphine 9 98.52 Very High Very High Very High
Inflammatory mediators 2 90.48 High High
cINOD 5 87.24 High High
Inflammation 18 85.24 High High
endometriosis 4 76.64 Quite High
anesthesia 6 54.16 Quite High
pain pelvic 1 49.72 Quite Low
Disease Link Frequency Relevance Heat
Cancer 222 99.86 Very High Very High Very High
Glioblastoma 32 99.84 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 5 99.84 Very High Very High Very High
Anaplastic Astrocytoma 114 99.44 Very High Very High Very High
Breast Cancer 38 98.98 Very High Very High Very High
Obesity 260 98.80 Very High Very High Very High
Medulloblastoma 4 96.84 Very High Very High Very High
Toxicity 19 93.92 High High
Endometriosis 5 92.84 High High
Endometriosis (extended) 10 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This contrasts with erb-38, for which an LD50 value in mice of 450 ?
Gene_expression (contrasts) of erb
1) Confidence 0.65 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1242130 Disease Relevance 1.01 Pain Relevance 0
CONCLUSION: In view of our observation that ER beta but not ER alpha is expressed regularly in normal human synovia in high amounts, we propose that estrogen could play a significant role in synovial membrane function in women and men, operating preferably via the ER beta isoform.


Gene_expression (expressed) of ER beta
2) Confidence 0.65 Published 2006 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 16990033 Disease Relevance 0 Pain Relevance 0
For ESR2 SNPs rs1152582, rs1271572 and rs1269056, allelic associations with obesity were observed in women, nominal P value 0.03–0.05, but not in joint analysis of women and men, Table 4.
Gene_expression (rs1152582) of ESR2 in joint associated with obesity
3) Confidence 0.65 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.90 Pain Relevance 0
UNLABELLED: Human vascular endothelial cells express the estrogen receptor-beta (ER-beta), which can be modulated by the opiate alkaloid morphine.
Gene_expression (express) of estrogen receptor-beta in endothelial cells associated with opiate and morphine
4) Confidence 0.64 Published 2002 Journal Neuro Endocrinol. Lett. Section Abstract Doc Link 12011792 Disease Relevance 0 Pain Relevance 0.27
Both ESR1 and ESR2 are expressed in the hypothalamus, a brain area known to be involved in the regulation of appetite and satiety [5], whilst adipocytes express mainly ESR1 [6].
Gene_expression (expressed) of ESR2 in brain associated with obesity
5) Confidence 0.58 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.82 Pain Relevance 0
Fresh synovial tissue specimens were assessed for the localization as well as the presence of estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta) by means of immunohistochemistry, as well as Western blot and reverse transcriptase-polymerase chain reaction (RT-PCR), respectively.
Gene_expression (presence) of ER beta
6) Confidence 0.51 Published 2006 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 16990033 Disease Relevance 0 Pain Relevance 0
RESULTS: ER beta protein and mRNA were found to be equally and highly expressed in synovial stroma and lining cells of all explants independent of sex or menopausal status.
Gene_expression (expressed) of ER beta protein in lining cells
7) Confidence 0.51 Published 2006 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 16990033 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: These results indicate that ER-beta is expressed in human vascular endothelial cells, and morphine appears to regulate this receptor in a similar fashion as the mu opiate receptor.


Gene_expression (expressed) of ER-beta in endothelial cells
8) Confidence 0.49 Published 2002 Journal Neuro Endocrinol. Lett. Section Body Doc Link 12011792 Disease Relevance 0 Pain Relevance 0
Total RNA was isolated from treated and untreated primary endothelial cells, and specific primers and a probe were used to determine the ER-beta gene expression by real-time RT-PCR.
Spec (determine) Gene_expression (expression) of ER-beta in endothelial cells
9) Confidence 0.49 Published 2002 Journal Neuro Endocrinol. Lett. Section Body Doc Link 12011792 Disease Relevance 0 Pain Relevance 0
UNLABELLED: Human vascular endothelial cells express the estrogen receptor-beta (ER-beta), which can be modulated by the opiate alkaloid morphine.
Gene_expression (express) of ER-beta in endothelial cells associated with opiate and morphine
10) Confidence 0.49 Published 2002 Journal Neuro Endocrinol. Lett. Section Abstract Doc Link 12011792 Disease Relevance 0 Pain Relevance 0.27
This study was an extension of our research on erb receptor expression in glioblastomas [8,29], and was designed to investigate the extent of EGFR gene amplification and overexpression in anaplastic astrocytomas.
Gene_expression (expression) of erb associated with anaplastic astrocytoma and glioblastoma
11) Confidence 0.46 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2859381 Disease Relevance 0.76 Pain Relevance 0.05
The distribution of tumor cells overexpressing erb proteins was both diffuse and dispersed with intensity varying from weak to strong.
Gene_expression (overexpressing) of erb associated with cancer
12) Confidence 0.46 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2859381 Disease Relevance 0.50 Pain Relevance 0
However, there is limited knowledge concerning the occurrence of EGFR gene amplification and the expression of erb-receptors in anaplastic astrocytomas [27,28].
Gene_expression (expression) of erb associated with anaplastic astrocytoma
13) Confidence 0.46 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2859381 Disease Relevance 0.73 Pain Relevance 0
The purpose of this study was to test the hypothesis that acetaminophen would alter an estrogen-regulated process in human cells that express endogenous estrogen receptor alpha and beta (ERalpha and ERbeta).
Gene_expression (express) of estrogen receptor alpha and beta associated with paracetamol
14) Confidence 0.43 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12604834 Disease Relevance 0.16 Pain Relevance 0.41
The purpose of this study was to test the hypothesis that acetaminophen would alter an estrogen-regulated process in human cells that express endogenous estrogen receptor alpha and beta (ERalpha and ERbeta).
Gene_expression (express) of ERbeta associated with paracetamol
15) Confidence 0.37 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12604834 Disease Relevance 0.17 Pain Relevance 0.41
Cooperation between erb proteins may also be of clinical relevance as mutual expression of c-erbB2 and c-erbB4 serves as an independent negative prognostic factor in childhood medulloblastoma [56].
Gene_expression (expression) of erb associated with medulloblastoma
16) Confidence 0.36 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2859381 Disease Relevance 0.54 Pain Relevance 0
For this study we selected seven breast cancer-associated genes [mam, CEA, CK19, PIP, muc1, PSE, Erb (BM only) and EpCAM (PBL only)] known to be over-expressed in metastatic breast cancer compared to control lymph nodes [31,36,37].
Gene_expression (expressed) of Erb in lymph nodes associated with breast cancer and advanced or metastatic breast cancer
17) Confidence 0.22 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.66 Pain Relevance 0
RESULTS: ER beta protein and mRNA were found to be equally and highly expressed in synovial stroma and lining cells of all explants independent of sex or menopausal status.
Gene_expression (expressed) of ER beta protein in stroma
18) Confidence 0.17 Published 2006 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 16990033 Disease Relevance 0 Pain Relevance 0
Interestingly, expression of estrogen receptor-beta has been characterized in astrocytic tumors, showing that as tumor grade increases, estrogen receptor-beta expression decreases [7].
Gene_expression (expression) of estrogen receptor-beta associated with cancer
19) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1513391 Disease Relevance 1.22 Pain Relevance 0.35
Interestingly, expression of estrogen receptor-beta has been characterized in astrocytic tumors, showing that as tumor grade increases, estrogen receptor-beta expression decreases [7].
Gene_expression (expression) of estrogen receptor-beta associated with cancer
20) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1513391 Disease Relevance 1.18 Pain Relevance 0.36

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