INT102237

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 22
Total Number 25
Disease Relevance 7.77
Pain Relevance 4.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP3) extracellular space (MMP3) extracellular region (MMP3)
proteinaceous extracellular matrix (MMP3) nucleus (MMP3) protein complex (MMP3)
Anatomy Link Frequency
chondrocytes 4
tendon 2
fibroblast 2
endometrium 2
MMP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 278 100.00 Very High Very High Very High
cytokine 135 99.98 Very High Very High Very High
endometriosis 92 99.20 Very High Very High Very High
rheumatoid arthritis 86 98.60 Very High Very High Very High
Inflammation 149 97.32 Very High Very High Very High
Pain 38 91.76 High High
Osteoarthritis 200 86.16 High High
Arthritis 55 83.36 Quite High
fibrosis 6 76.24 Quite High
cva 14 75.84 Quite High
Disease Link Frequency Relevance Heat
Endometriosis 131 99.20 Very High Very High Very High
Injury 65 98.96 Very High Very High Very High
Transitional Cell Carcinoma 26 98.92 Very High Very High Very High
Rheumatoid Arthritis 87 98.60 Very High Very High Very High
Disease 132 97.40 Very High Very High Very High
INFLAMMATION 166 97.32 Very High Very High Very High
Apoptosis 45 96.32 Very High Very High Very High
Tendinopathy 1 95.92 Very High Very High Very High
Cancer 54 93.52 High High
Aggression 2 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, cytokines are known to stimulate the production of MMPs (Ito et al., 1991; Imada et al., 1997a, b; Oner et al., 2008), so it would be logical to expect an elevation of MMP-1 and MMP-3 levels when there is an increased secretion of IL-8.
Positive_regulation (elevation) of Gene_expression (levels) of MMP-3 associated with metalloproteinase and cytokine
1) Confidence 0.44 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0 Pain Relevance 0.41
One group investigated MMP1 and MMP3 protein expression by immunohistochemistry [15].
Spec (investigated) Positive_regulation (investigated) of Spec (investigated) Gene_expression (expression) of MMP3
2) Confidence 0.43 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.11 Pain Relevance 0.20
However, changes in both MMP3 and MMP13 gene expression are rapid, dramatic, sustained, and changing during at least the first 48 h of unloaded culture.
Positive_regulation (changes) of Gene_expression (expression) of MMP3
3) Confidence 0.42 Published 2008 Journal J. Orthop. Res. Section Abstract Doc Link 18404723 Disease Relevance 0.36 Pain Relevance 0.10
MMP-3 expression is induced in response to local conditions such as mechanical loading 48 and inflammation 49.
Positive_regulation (induced) of Gene_expression (expression) of MMP-3 associated with inflammation
4) Confidence 0.41 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.34 Pain Relevance 0.05
The increased protein levels of MMP-1 and MMP-3 were also reduced by 1000 microg/ml HA.
Positive_regulation (increased) of Gene_expression (levels) of MMP-3 associated with metalloproteinase
5) Confidence 0.41 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.20 Pain Relevance 0.89
Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells.
Positive_regulation (enhances) of Gene_expression (expression) of matrix metalloproteinase 3 in tendon associated with metalloproteinase
6) Confidence 0.40 Published 2002 Journal Arthritis Rheum. Section Title Doc Link 12428247 Disease Relevance 0.10 Pain Relevance 0.19
stimulation, levels of MMP-1, MMP-3 and MMP-13 production were markedly increased.
Positive_regulation (increased) of Gene_expression (production) of MMP-3
7) Confidence 0.38 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212570 Disease Relevance 0 Pain Relevance 0
NSAID did not modify MMP-3 production.
Neg (not) Positive_regulation (modify) of Gene_expression (production) of MMP-3
8) Confidence 0.36 Published 2002 Journal J. Rheumatol. Section Body Doc Link 11950021 Disease Relevance 0 Pain Relevance 0
resulted in upregulation of mRNA and protein expression of collagenases MMP-1 and MMP-13 and the stromelysin MMP-3.
Positive_regulation (upregulation) of Gene_expression (expression) of MMP-3
9) Confidence 0.27 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0.33 Pain Relevance 0.12
Our results demonstrate that PHT as well as its metabolite, HPPH significantly blunt A. actinomycetemcomitans LPS-induced levels of MMP-1, MMP-3, MMP-9 and TIMP-1 in a dose-dependent manner and that a high concentration of PHT significantly decreases TNF-?
Positive_regulation (induced) of Gene_expression (levels) of MMP-3
10) Confidence 0.27 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.08 Pain Relevance 0.18
Interestingly, a trend for higher levels of MMP-1 were noted in cultures treated with HPPH while MMP-3 levels were slightly elevated in cultures treated with either PHT and HPPH although neither reached statistical significance (p > 0.05) (Fig. 1, A, C).
Positive_regulation (elevated) of Gene_expression (levels) of MMP-3
11) Confidence 0.27 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0 Pain Relevance 0
g/mL PHT prior to LPS stimulation significantly blunted supernatant MMP-3 levels (p < 0.01 and p < 0.001, respectively, Fig. 1C) compared to LPS-only treated cultures.
Positive_regulation (supernatant) of Gene_expression (levels) of MMP-3
12) Confidence 0.27 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0 Pain Relevance 0
stimulated by 1,500-fold the expression of MMP-3 mRNA.
Positive_regulation (stimulated) of Gene_expression (expression) of MMP-3 mRNA
13) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0 Pain Relevance 0.04
Therefore, in vitro IL-1 causes an increase expression of MMP-3, an enzyme increased in the degenerate disc [6]
Positive_regulation (increase) of Gene_expression (expression) of MMP-3
14) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.05 Pain Relevance 0.03
Therefore, in vitro IL-1 causes an increase expression of MMP-3, an enzyme increased in the degenerate disc [6]
Positive_regulation (increased) of Gene_expression (expression) of MMP-3
15) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.05 Pain Relevance 0.03
Following treatment with IL-1, an increase in MMP-3 gene expression was seen in the four cell types investigated (though the increase was significant only in cells derived from the non-degenerate NP and AF (P < 0.05)) (Fig. 4a).
Positive_regulation (increase) of Gene_expression (expression) of MMP-3
16) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0 Pain Relevance 0
Ibuprofen produced similar effects on the expression of MMP-1 (23.4 +/- 5.0, P = .016) and MMP-3 (26.3 +/- 4.2, P = .003).
Positive_regulation (produced) of Gene_expression (expression) of MMP-3
17) Confidence 0.20 Published 2006 Journal Clin. Pharmacol. Ther. Section Body Doc Link 16580899 Disease Relevance 0.11 Pain Relevance 0
MMP-3 expression was only slightly induced at low concentration and significance was reached at 5 ?
Positive_regulation (induced) of Gene_expression (expression) of MMP-3 associated with metalloproteinase
18) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.41 Pain Relevance 0.29
-induced production of MMP-1 and MMP-3 at the protein and mRNA levels in RA synovial fibroblast by inhibiting activation protein-1 DNA binding activity [42].
Positive_regulation (induced) of Gene_expression (production) of MMP-3 in fibroblast associated with rheumatoid arthritis
19) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.96 Pain Relevance 0.36
Studies with cartilage explants that are subjected to mechanical impact injury demonstrate that the remaining viable chondrocytes express increased levels of matrix metalloproteinase (MMP)-1, MMP-3, MMP-8, MMP-9, MMP-13 and ADAM-TS5 [46,47].
Positive_regulation (increased) of Gene_expression (express) of MMP-3 in chondrocytes associated with injury and metalloproteinase
20) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 0.36 Pain Relevance 0.38

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