INT102249

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 39
Total Number 39
Disease Relevance 30.47
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
Anatomy Link Frequency
nucleus 4
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 300 99.44 Very High Very High Very High
Central nervous system 19 97.96 Very High Very High Very High
fortral 2 93.72 High High
agonist 132 93.08 High High
Inflammation 346 85.68 High High
antagonist 63 85.40 High High
Inflammatory response 30 84.88 Quite High
Chronic pancreatitis 33 74.56 Quite High
metalloproteinase 69 72.64 Quite High
Dopamine 1 66.36 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 932 100.00 Very High Very High Very High
Targeted Disruption 19 100.00 Very High Very High Very High
Pancreatic Cancer 896 99.72 Very High Very High Very High
Cancer 2094 99.20 Very High Very High Very High
Brain Tumor 20 98.64 Very High Very High Very High
Hemangioma 3 98.48 Very High Very High Very High
Death 46 97.80 Very High Very High Very High
Apoptosis 193 97.72 Very High Very High Very High
Pulmonary Hypertension 340 97.64 Very High Very High Very High
Increased Venous Pressure Under Development 35 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, strong staining for HIF-1?
HIF Binding (staining) of
1) Confidence 0.36 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.64 Pain Relevance 0.10
HIF-1alpha knockdown by RNA interference attenuates rimcazole-induced cell death in both cell types.
HIF-1alpha Binding (knockdown) of associated with death
2) Confidence 0.36 Published 2007 Journal Oncogene Section Abstract Doc Link 16924239 Disease Relevance 0.64 Pain Relevance 0.18
With regard to pneumothorax cases, these were immunohistochemically unreactive and, hence, no relationship was noted between HIF1alpha and anesthesia parameters.
HIF1alpha Binding (noted) of
3) Confidence 0.36 Published 2010 Journal Anticancer Res. Section Body Doc Link 20530420 Disease Relevance 0.14 Pain Relevance 0
Further, an electrophoretic mobility shift assay (EMSA) from nuclear extracts from melanoma cells showed a decrease in constitutive activation of NF-kappaB and enhanced HIF-1alpha binding activity to hypoxia response element (HRE) in melanoma cells treated with different concentrations of capsaicin.
HIF-1alpha Binding (activity) of
4) Confidence 0.35 Published 2002 Journal J. Cancer Res. Clin. Oncol. Section Body Doc Link 12242509 Disease Relevance 0.07 Pain Relevance 0
The hypoxia-inducible factor-1 (HIF-1) is a transcription complex that regulates many genes involved in the response to hypoxia, including vasodilation, and by upregulating VEGF-A induces angiogenesis.
hypoxia-inducible factor-1 Binding (complex) of associated with hypoxia and increased venous pressure under development
5) Confidence 0.35 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.89 Pain Relevance 0
HIF-1 DNA-binding is also increased by insulin, and by interleukin-1 and tumor necrosis factor.
HIF-1 Binding (binding) of associated with necrosis and cancer
6) Confidence 0.25 Published 2001 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 11950137 Disease Relevance 0.94 Pain Relevance 0.04
to form the HIF-1 complex, and activation of transcription through HIF-1's binding to specific HREs in target sequences (see Figure 2).
HIF-1 complex Binding (binding) of
7) Confidence 0.25 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.60 Pain Relevance 0.03
stabilization and translocation to the cell nucleus, dimerization with HIF-1?
HIF-1 Binding (dimerization) of in nucleus
8) Confidence 0.25 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.57 Pain Relevance 0.03
To activate transcription of hypoxia-regulated genes, the intact heterodimeric HIF-1 complex binds DNA at specific HREs characterized by the consensus sequence 5'-RCGTG-3' [23].
HIF-1 complex Binding (binds) of associated with hypoxia
9) Confidence 0.25 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.35 Pain Relevance 0
translocates to the nucleus in a process mediated by specific nuclear localization signals and dimerizes with HIF-1?
HIF-1 Binding (dimerizes) of in nucleus
10) Confidence 0.25 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.36 Pain Relevance 0
However, knockout of HIF-1?
HIF-1 Binding (knockout) of associated with targeted disruption
11) Confidence 0.23 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 1.10 Pain Relevance 0
subunit to accumulate, translocate to the nucleus, and heterodimerize with HIF-1?
HIF-1 Binding (heterodimerize) of in nucleus
12) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.83 Pain Relevance 0.04
Under hypoxic conditions, the HIF-1?
HIF-1 Binding (Under) of associated with hypoxia
13) Confidence 0.19 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.49 Pain Relevance 0
The VHL protein contains a binding site in the oxygen-dependent degradation domain (ODD) of HIF-1?
HIF-1 Binding (binding) of
14) Confidence 0.19 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.59 Pain Relevance 0.05
Interestingly, recent studies are beginning to define a role for HIF-1?
HIF-1 Binding (role) of
15) Confidence 0.19 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 1.51 Pain Relevance 0
HIF-1 is a heterodimer formed by the association of ?
HIF-1 Binding (heterodimer) of
16) Confidence 0.19 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.79 Pain Relevance 0
Interestingly, in these studies, HIF-1?
HIF-1 Binding (Interestingly) of
17) Confidence 0.19 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 1.15 Pain Relevance 0.03
In vitro all pancreatic cancer cell lines increased VEGF production under low oxygen levels by highly specific activation of HIF-1 DNA binding activity to the VEGF promotor [43].
HIF-1 Binding (activity) of associated with pancreatic cancer
18) Confidence 0.19 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 1.47 Pain Relevance 0.07
to form the HIF-1 complex, and activation of transcription through HIF-1's binding to specific HREs in target sequences (see Figure 2).
HIF-1 Binding (binding) of
19) Confidence 0.19 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.59 Pain Relevance 0.03
thereby preventing formation of an active HIF-1 heterodimer [147].
HIF-1 Binding (formation) of
20) Confidence 0.16 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.86 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox