INT102251

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 29.62
Pain Relevance 7.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp)
Anatomy Link Frequency
plasma 10
liver 3
coronary artery 2
erythrocyte 2
monocytes 2
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 264 100.00 Very High Very High Very High
Paracetamol 8 99.98 Very High Very High Very High
Angina 51 99.90 Very High Very High Very High
cytokine 66 99.68 Very High Very High Very High
spondylitis 49 99.42 Very High Very High Very High
Inflammatory response 32 99.12 Very High Very High Very High
abdominal pain 11 98.22 Very High Very High Very High
Adalimumab 57 97.12 Very High Very High Very High
imagery 13 90.80 High High
backache 2 90.32 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 238 100.00 Very High Very High Very High
Mycobacterial Infection 98 100.00 Very High Very High Very High
Hypertension 46 100.00 Very High Very High Very High
Nicotine Addiction 18 100.00 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

3 100.00 Very High Very High Very High
Alzheimer's Dementia 2 100.00 Very High Very High Very High
Neuropathic Pain 2 100.00 Very High Very High Very High
Cv General 3 Under Development 41 99.90 Very High Very High Very High
Diabetes Mellitus 89 99.82 Very High Very High Very High
Thrombosis 9 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma levels of C-reactive protein (CRP), von Willebrand factor (vWF), IL-6, IL-10 and TNF-alpha were significantly increased by acetaminophen treatment (P < 0.05); and SAC or SPC intake significantly suppressed acetaminophen-induced elevation of CRP, vWF and the three cytokines (P < 0.05).
Positive_regulation (induced) of Positive_regulation (elevation) of CRP in Plasma associated with paracetamol and cytokine
1) Confidence 0.58 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16181716 Disease Relevance 0.22 Pain Relevance 0.70
It might be that elevated CRP levels in ED patients are most frequently induced by an infection, and thus CRP becomes a good marker of infection in ED.
Positive_regulation (induced) of Positive_regulation (elevated) of CRP associated with infection
2) Confidence 0.53 Published 2004 Journal Crit Care Section Body Doc Link PMC420058 Disease Relevance 1.31 Pain Relevance 0.27
We evaluated plasma levels of procalcitonin and C-reactive protein (CRP) in 52 patients admitted to our intensive cardiac care unit (ICCU): 14 patients with cardiogenic shock (CS) following ST-elevation myocardial infarction (STEMI), 15 patients with uncomplicated ST-elevation myocardial infarction (STEMI), and 24 with non-ST-elevation myocardial infarction or unstable angina (NSTEMI/UA).
Positive_regulation (evaluated) of Positive_regulation (levels) of CRP in plasma associated with angina, cv general 2 under development and myocardial infarction
3) Confidence 0.49 Published 2009 Journal Intern Emerg Med Section Abstract Doc Link 19585221 Disease Relevance 1.53 Pain Relevance 0.19
We evaluated plasma levels of procalcitonin and C-reactive protein (CRP) in 52 patients admitted to our intensive cardiac care unit (ICCU): 14 patients with cardiogenic shock (CS) following ST-elevation myocardial infarction (STEMI), 15 patients with uncomplicated ST-elevation myocardial infarction (STEMI), and 24 with non-ST-elevation myocardial infarction or unstable angina (NSTEMI/UA).
Positive_regulation (evaluated) of Positive_regulation (levels) of C-reactive protein in plasma associated with angina, cv general 2 under development and myocardial infarction
4) Confidence 0.49 Published 2009 Journal Intern Emerg Med Section Abstract Doc Link 19585221 Disease Relevance 1.52 Pain Relevance 0.19
It has been hypothesized that necrosis is a strong stimulus for CRP increase in patients suffering from myonecrosis [21].
Positive_regulation (stimulus) of Positive_regulation (increase) of CRP associated with necrosis and anaerobic bacterial infections
5) Confidence 0.49 Published 2007 Journal BMC Surg Section Body Doc Link PMC1925058 Disease Relevance 1.34 Pain Relevance 0.28
However, the high negative predictive value of any elevated CRP (0.96 for participants with confirmed tuberculosis and 0.72 for all with tuberculosis) suggests that a normal CRP would be useful for ruling out tuberculosis.
Positive_regulation (0.72) of Positive_regulation (elevated) of CRP associated with mycobacterial infection
6) Confidence 0.48 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018418 Disease Relevance 1.93 Pain Relevance 0
In our recent study, the results demonstrate that monocytes exhibit an enhanced production of interleukin-6 (IL-6) in response to CRP, and this response is significantly inhibited by simvastatin in a dose-dependent manner.
Positive_regulation (enhanced) of Positive_regulation (response) of CRP in monocytes
7) Confidence 0.46 Published 2004 Journal Med. Hypotheses Section Abstract Doc Link 15050096 Disease Relevance 1.50 Pain Relevance 0.26
Our data have showed that increased level of CRP in patients with unstable angina was associated with short-term clinical outcomes, response for conventional therapy, and activation of nuclear factor-kappa B (NF-kappaB), but it is not correlated to coronary artery stenosis as well as lipid profile.
Positive_regulation (increased) of Positive_regulation (increased) of CRP in coronary artery associated with coronary stenosis and angina
8) Confidence 0.46 Published 2004 Journal Med. Hypotheses Section Abstract Doc Link 15050096 Disease Relevance 1.36 Pain Relevance 0.26
We investigated whether elevated CRP is related to the activation of the terminal complement cascade in 66 patients with unstable angina pectoris (UAP), in 45 patients with stable angina pectoris, and in 42 controls.
Spec (whether) Positive_regulation (activation) of Spec (whether) Positive_regulation (elevated) of CRP associated with stable angina pectoris and angina
9) Confidence 0.46 Published 2002 Journal Am. J. Cardiol. Section Abstract Doc Link 11950426 Disease Relevance 0.98 Pain Relevance 0.88
In patients with UAP and elevated CRP, the plasma levels of sC5b-9 were markedly higher than in patients with UAP and lower CRP (245 +/- 14 vs 188 +/- 19 ng/ml, p <0.02) and in patients with stable angina pectoris with slightly (0.4 +/- 0.1 mg/dl) increased CRP (sC5b-9 173 +/- 21 vs 130 +/- 7 ng/ml [controls; p <0.05]).
Positive_regulation (higher) of Positive_regulation (elevated) of CRP in plasma associated with stable angina pectoris and angina
10) Confidence 0.46 Published 2002 Journal Am. J. Cardiol. Section Abstract Doc Link 11950426 Disease Relevance 1.21 Pain Relevance 1.10
Thus, CRP within coronary plaque might contribute to increased plasma CRP levels across coronary circulation, particularly among patients with unstable angina pectoris.
Spec (might) Positive_regulation (contribute) of Spec (might) Positive_regulation (increased) of CRP in plasma associated with angina
11) Confidence 0.46 Published 2004 Journal Am. J. Cardiol. Section Abstract Doc Link 14996590 Disease Relevance 0.48 Pain Relevance 0.48
The tissue damage in myocardial necrosis leads to an inflammatory reaction which is reflected for example, in increased levels of C-reactive protein (CRP), cytokines and fibrinogen [10,11].
Positive_regulation (increased) of Positive_regulation (levels) of C-reactive protein associated with necrosis, inflammation and cytokine
12) Confidence 0.45 Published 2009 Journal Thromb J Section Body Doc Link PMC2715384 Disease Relevance 1.09 Pain Relevance 0.19
RESULTS: The test for a trend toward increasing intercellular adhesion molecule (ICAM)-1 concentrations by the 75th percentile of CRP levels at 72 h after coronary stenting was significant (p = 0.03).
Positive_regulation (increasing) of Positive_regulation (percentile) of CRP
13) Confidence 0.43 Published 2005 Journal Clin Cardiol Section Body Doc Link 15704532 Disease Relevance 0.08 Pain Relevance 0
An intense inflammatory response is expected following PCI in patients with increased baseline CRP levels, which can cause small vessel occlusion and/or microembolization that will lead to troponin elevation.
Positive_regulation (lead) of Positive_regulation (increased) of CRP associated with inflammatory response
14) Confidence 0.42 Published 2003 Journal Med. Sci. Monit. Section Abstract Doc Link 12942045 Disease Relevance 1.17 Pain Relevance 0.41
mTSS and baseline CRP, probably because an elevated CRP tends to remain elevated without treatment (Figure 2d).
Positive_regulation (elevated) of Positive_regulation (elevated) of CRP
15) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911906 Disease Relevance 0.43 Pain Relevance 0.33
Certain patients were not enrolled, especially those with elevated CRP levels induced by stimuli other than bacterial infection.
Positive_regulation (induced) of Positive_regulation (elevated) of CRP associated with bacterial infection
16) Confidence 0.35 Published 2004 Journal Crit Care Section Body Doc Link PMC420058 Disease Relevance 1.03 Pain Relevance 0.16
Certain patients were not enrolled, especially those with elevated CRP levels induced by stimuli other than bacterial infection.
Positive_regulation (elevated) of Positive_regulation (induced) of CRP associated with bacterial infection
17) Confidence 0.35 Published 2004 Journal Crit Care Section Body Doc Link PMC420058 Disease Relevance 1.03 Pain Relevance 0.16
In tuberculous spondylitis, 80% of the cases showed an increased erythrocyte sedimentation rate than an increase in the level of CRP.
Positive_regulation (increased) of Positive_regulation (increase) of CRP in erythrocyte associated with spondylitis
18) Confidence 0.33 Published 2007 Journal Asian Spine Journal Section Body Doc Link PMC2857479 Disease Relevance 1.21 Pain Relevance 0.65
For example, liver-derived inflammation markers such as C-reactive protein (CRP) and serum amyloid A (SAA) increase rapidly (within days) after consumption of an excess amount of dietary lipids [8,10], and thus by far precede the onset of early aortic lesion formation [8].
Positive_regulation (derived) of Positive_regulation (increase) of CRP in liver associated with inflammation and alzheimer's dementia
19) Confidence 0.31 Published 2007 Journal Genome Biol Section Body Doc Link PMC2375038 Disease Relevance 1.39 Pain Relevance 0.34
Hypertension plus cardiovascular disease or hyperlipidemia seems to be responsible for the elevation of CRP levels.
Positive_regulation (responsible) of Positive_regulation (elevation) of CRP associated with cardiovascular disease, hypertension and hyperlipidemia
20) Confidence 0.30 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2274989 Disease Relevance 2.58 Pain Relevance 0.03

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