INT102254

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 7
Speculated 2
Reported most in Body
Documents 72
Total Number 74
Disease Relevance 38.11
Pain Relevance 4.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
brain 10
neurons 9
neuronal 8
Notch 2
nervous tissue 2
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 215 99.16 Very High Very High Very High
ischemia 176 97.44 Very High Very High Very High
Glutamate 88 97.04 Very High Very High Very High
Lasting pain 2 96.84 Very High Very High Very High
Dynorphin 2 96.60 Very High Very High Very High
Cholecystokinin 2 95.64 Very High Very High Very High
nMDA receptor 23 95.56 Very High Very High Very High
Neuronal excitability 47 95.52 Very High Very High Very High
Enkephalin 2 94.80 High High
Neuropeptide 6 94.24 High High
Disease Link Frequency Relevance Heat
Disease 1023 100.00 Very High Very High Very High
Targeted Disruption 741 100.00 Very High Very High Very High
Alzheimer's Dementia 458 100.00 Very High Very High Very High
Encephalopathy 150 100.00 Very High Very High Very High
Infection 317 99.60 Very High Very High Very High
Cytomegalovirus Infection 2 99.60 Very High Very High Very High
Neurodegenerative Disease 78 99.50 Very High Very High Very High
Sprains And Strains 912 99.28 Very High Very High Very High
Hypercapnia 3 99.28 Very High Very High Very High
Stress Incontinence 280 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RT-PCR analysis revealed a significantly increased expression of Prnp in the infarct-free region of the ipsilateral hemisphere after ischemia (P < 0.05).
Positive_regulation (increased) of Gene_expression (expression) of Prnp associated with ischemia
1) Confidence 0.70 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.51 Pain Relevance 0.22
This raises the intriguing possibility that enhanced PrP expression may be a compensatory mechanism to protect from NMDAR-mediated cell damage during ischemic insults.
Positive_regulation (enhanced) of Gene_expression (expression) of PrP
2) Confidence 0.69 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.90 Pain Relevance 0.04
Mice lacking PrPC show increased neuronal damage after ischemic stroke, whereas protection is evident upon the viral-based overexpression of PrPC in rats (McLennan et al., 2004; Shyu et al., 2005; Spudich et al., 2005; Weise et al., 2006).
Positive_regulation (overexpression) of Gene_expression (overexpression) of PrPC in neuronal associated with stroke
3) Confidence 0.69 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.62 Pain Relevance 0.18
Conversely, the overexpression of Prnp cDNA in neurons obtained from PrP-null mice rescued the WT phenotype (Fig. 3 F), again hinting at a specific regulation of NMDARs by PrPC rather than broad developmental effects associated with deletion of the Prnp gene.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Prnp in neurons
4) Confidence 0.69 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.06 Pain Relevance 0.04
Our data show a robust enhancement of synaptic NMDA currents in PrP-null mice, which could be mimicked upon siRNA depletion of PrPC and rescued by overexpression of exogenous Prnp cDNA.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Prnp
5) Confidence 0.69 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.34 Pain Relevance 0.10
Four inbred mouse strains (SJL, RIII, C57Bl/6, and VM) and transgenic mice overexpressing bovine PrP with six octapeptide repeats on a murine PrP knockout background (Tgbov XV) [20] were used for the study.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PrP associated with targeted disruption and sprains and strains
6) Confidence 0.68 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1817656 Disease Relevance 1.58 Pain Relevance 0.04
Mice overexpressing ovine PrP (tg338 line [24]) were infected intraperitoneally with 100 ┬Ál of the 127S scrapie strain at 0.02% (w/v) dose.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PrP associated with scrapie and sprains and strains
7) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291559 Disease Relevance 0.61 Pain Relevance 0
It is noteworthy that neurological deficits in Tg mice overexpressing PrP are not uncommon and are distinct from those caused by prion infection.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PrP associated with targeted disruption and infection
8) Confidence 0.68 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2809756 Disease Relevance 1.08 Pain Relevance 0.20
Mitochondrial localization of cellular prion protein (PrPC) invokes neuronal apoptosis in aged transgenic mice overexpressing PrPC.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PrPC in neuronal associated with targeted disruption and neurodegenerative disease
9) Confidence 0.61 Published 2005 Journal Neurosci. Lett. Section Title Doc Link 15644272 Disease Relevance 0.71 Pain Relevance 0.09
Overall, these data demonstrate that PrP transport to LEs is not required for PrPSc production and rule out the involvement of LEs in scrapie conversion.
Positive_regulation (required) of Gene_expression (production) of PrPSc associated with scrapie
10) Confidence 0.60 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.15 Pain Relevance 0
We inoculated three synthetic prion isolates into Tg4053 mice that overexpress full-length PrP; Tg4053 mice are not prone to developing spontaneous neurological dysfunction.
Positive_regulation (overexpress) of Neg (not) Gene_expression (overexpress) of PrP associated with anesthesia
11) Confidence 0.59 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2809756 Disease Relevance 0.51 Pain Relevance 0.18
The changes occurred more rapidly in PrP(C)-overexpressing compared to wild-type mice, and could not be found at all in PrP(C)-knockout mice.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PrP associated with targeted disruption
12) Confidence 0.56 Published 2007 Journal Neurobiol. Aging Section Abstract Doc Link 16621165 Disease Relevance 0.38 Pain Relevance 0.52
In our experiments this interaction could not be initiated by PrP lacking the octapeptide and flanking amino acids (PrP?
Positive_regulation (by) of Neg (lacking) Gene_expression (lacking) of PrP
13) Confidence 0.50 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.66 Pain Relevance 0.12
Mice lacking or overexpressing PrP(c) and their respective controls showed similar ventilatory patterns at rest and similar chemosensory responses when awake and under urethane anesthesia.
Positive_regulation (overexpressing) of Neg (lacking) Gene_expression (overexpressing) of PrP associated with anesthesia
14) Confidence 0.50 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11950500 Disease Relevance 0.29 Pain Relevance 0.09
Another group created transgenic mice stably expressing PrP shRNA that reduced PrPC expression five-fold, although they did not assess prion disease in these animals [25].
Positive_regulation (created) of Gene_expression (expressing) of PrP associated with targeted disruption and prion diseases
15) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.68 Pain Relevance 0
RNAi was first shown to effectively knock down PrPC expression in cells transfected with PrP-encoding plasmids [24].
Positive_regulation (transfected) of Gene_expression (transfected) of PrP associated with targeted disruption
16) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 1.12 Pain Relevance 0.12
A possible functional relation between neurofascin and PrPC is particularly intriguing in view of the lethal phenotype of transgenic mice expressing PrP deletion mutants, which display extensive central and peripheral myelin degeneration [19].
Positive_regulation (intriguing) of Gene_expression (expressing) of PrP associated with targeted disruption
17) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.26 Pain Relevance 0
Indeed, by inhibiting PrP exit from the ERC using the Rab11 dominant-negative mutant, we found an increase in PrPSc levels, supporting the hypothesis that prion accumulation in the ERC stimulates PrPSc production.
Positive_regulation (stimulates) of Gene_expression (production) of PrPSc
18) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.20 Pain Relevance 0
By this approach we observed that unlike PrPC, only ?
Positive_regulation (observed) of Gene_expression (observed) of PrPC
19) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0.03
Tg338 mice overexpressing ovine PrP (VRQ allele) were intraperitoneally inoculated with a high dose of the 127S strain.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PrP associated with sprains and strains
20) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291559 Disease Relevance 0.45 Pain Relevance 0.47

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