INT102255

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 35
Total Number 40
Disease Relevance 18.97
Pain Relevance 3.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
neurons 3
brain 2
striatum 1
neurite 1
hypothalamus 1
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 6 100.00 Very High Very High Very High
Neuronal excitability 33 98.28 Very High Very High Very High
medulla 61 97.72 Very High Very High Very High
Somatosensory cortex 18 97.16 Very High Very High Very High
anesthesia 87 96.96 Very High Very High Very High
Thalamus 40 95.88 Very High Very High Very High
Hippocampus 89 92.24 High High
cerebral cortex 12 91.72 High High
gABA 4 91.44 High High
nMDA receptor 16 89.20 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 474 100.00 Very High Very High Very High
Toxicity 34 99.92 Very High Very High Very High
Gliosis 22 99.90 Very High Very High Very High
Disease 450 99.80 Very High Very High Very High
Creutzfeldt Jakob Disease 1149 99.58 Very High Very High Very High
Targeted Disruption 504 99.20 Very High Very High Very High
Nociception 16 99.20 Very High Very High Very High
Alzheimer's Dementia 278 98.80 Very High Very High Very High
Scrapie 197 98.04 Very High Very High Very High
Adhesions 6 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The up-regulation of PrPC mRNA levels in the area adjacent to the infarct may be triggered by local oxidative damage and other metabolic derangements in this area; this would be in keeping with in vitro analyses showing a correlation between PrP expression and oxidative stress (3).
Regulation (regulation) of PrPC mRNA associated with stress
1) Confidence 0.62 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.45 Pain Relevance 0.08
However, despite the drastic reduction in the number of LEs, the levels of total PrP and PrPSc were unaltered in Alix-depleted ScGT1 cells.
Regulation (unaltered) of PrP
2) Confidence 0.61 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.13 Pain Relevance 0
In order to detect the effect on PrPSc levels, both silencing and overexpression of proteins were required during 6-day period.
Regulation (effect) of PrPSc
3) Confidence 0.61 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
However, despite the drastic reduction in the number of LEs, the levels of total PrP and PrPSc were unaltered in Alix-depleted ScGT1 cells.
Regulation (unaltered) of PrPSc
4) Confidence 0.61 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.13 Pain Relevance 0
In particular, it is possible that impairment of PrP recycling in GFP-Rab22a expressing cells could divert PrP towards a degradation pathway.
Regulation (divert) of PrP
5) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
PrPSc levels in the brains of prion-inoculated MDR0/0 mice diminished upon the initiation of quinacrine treatment.
Regulation (inoculated) of PrPSc in brains
6) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2777304 Disease Relevance 0.25 Pain Relevance 0
Biochemical analyses - PK digestion, glycosylation ratio, and electrophoresis mobility - of end products revealed the same strain features as the original seeds, suggesting that strains are dependent on the properties of PrPSc [19-21].
Regulation (dependent) of PrPSc associated with sprains and strains
7) Confidence 0.39 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2950034 Disease Relevance 0.70 Pain Relevance 0.06
Genetic or siRNA-mediated PrPC depletion in these studies delayed or even prevented disease, while still replicating PrPSc to levels seen in wild type mice expressing normal levels of PrPC.
Regulation (replicating) of PrPSc associated with disease
8) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.93 Pain Relevance 0
Although in our hands the levels of PrPSc remained unaltered in ScN2a cells transfected with Rab4 dominant-negative, both of these sets of data concur in showing that recycling from EEs to the PM is not involved in scrapie production.


Regulation (unaltered) of PrPSc associated with scrapie
9) Confidence 0.39 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.24 Pain Relevance 0
In the same set of experiments we followed by Western blot analysis the level of total PrPC in non-infected MovS6 cells to determine if GA has any effect on the basal level of PrP expression in MovS6 cells, which could indirectly affect PrPSc accumulation (Figure 2 panel b, bottom).
Regulation (affect) of PrPSc
10) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291559 Disease Relevance 0 Pain Relevance 0
Using in situ hybridization and immunohistochemistry, we have studied changes in the expression of neuropeptides, acetylcholinesterase and tyrosine hydroxylase in CD1 and FVB wild-type mouse strains, as well as in PrP(C) null mice and in mice overexpressing PrP(C) following intracerebral inoculation with RML or Me7 prions.
Regulation (changes) of PrP associated with neuropeptide and sprains and strains
11) Confidence 0.37 Published 2007 Journal Neurobiol. Aging Section Abstract Doc Link 16621165 Disease Relevance 0.28 Pain Relevance 0.45
Controls for PrPSc IHC included the use of mock-infected tissues and substituting a similar concentration of murine IgG isotype control for the anti-PrP 3F4 monoclonal antibody.
Regulation (Controls) of PrPSc
12) Confidence 0.34 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2855443 Disease Relevance 0 Pain Relevance 0
Moreover, using in situ hybridization an increase of PrP mRNA levels and also PrP immunoreactivity were detected in penumbral neurons of the ischemic lesion (21).
Regulation (immunoreactivity) of PrP in neurons
13) Confidence 0.27 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.71 Pain Relevance 0.06
Intense PrPC immunoreactivity was seen in individual cells in the penumbra, while other neurons in this area showed no PrPC immunoreactivity.
Neg (no) Regulation (immunoreactivity) of PrPC in neurons
14) Confidence 0.27 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.59 Pain Relevance 0.06
Here we investigated the putative involvement of the PrP(c) function on the nociceptive response using PrP(c) null (Prnp(0/0)) and wild-type (Prnp(+/+)) mice submitted to thermal and chemical models of nociception.
Spec (investigated) Regulation (involvement) of PrP associated with nociception
15) Confidence 0.27 Published 2007 Journal Brain Res. Section Abstract Doc Link 17433806 Disease Relevance 0.52 Pain Relevance 0.12
LSPCs targeting PrPC, perhaps in combination with Amyloid Precursor protein expression may prove to be a potent therapy for a disease that affects millions of people worldwide.


Regulation (targeting) of PrPC associated with alzheimer's dementia and disease
16) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.80 Pain Relevance 0
To determine the physiological role of PrPC, we examine the neurophysiological properties of hippocampal neurons isolated from PrP-null mice.
Spec (determine) Regulation (role) of PrPC in neurons
17) Confidence 0.27 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2364707 Disease Relevance 0.10 Pain Relevance 0.14
Immunohistochemistry showed that uni- and multicentric PrP plaques in BSE mice were associated with substantial amounts of granular PrP deposits in the same areas, while diffuse PrP immunoreactivity was weak (Figure 1E and 1F).
Regulation (immunoreactivity) of PrP in plaques associated with creutzfeldt jakob disease
18) Confidence 0.27 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1817656 Disease Relevance 1.24 Pain Relevance 0.24
PrP immunoreactivity in the form of diffuse and focal deposits was mainly localized in the somatosensory cortex, striatum, thalamus, hypothalamus, septum, cerebellum, and medulla oblongata (Figure 6A–6E), and the PrPSc profile was marked by a protease-resistant fragment similar to that of cattle BSE with predominance of the high molecular mass glycoform (Figure 5C and 5F).
Regulation (immunoreactivity) of PrP in cortex associated with medulla, somatosensory cortex, creutzfeldt jakob disease and thalamus
19) Confidence 0.27 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1817656 Disease Relevance 0.72 Pain Relevance 0.19
Additionally, PrPSc levels were measured in MDR[60–90] mice at 7 other time-points (64, 69, 75, 78, 81, 84, and 88 dpi).
Regulation (measured) of PrPSc
20) Confidence 0.25 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777304 Disease Relevance 0.46 Pain Relevance 0.11

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